ENSG00000078114

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000417816 ENSG00000078114 HEK293_OSMI2_2hA HEK293_TMG_2hB NEBL protein_coding protein_coding 2.560019 2.004239 5.161978 0.2553725 0.2292988 1.360481 0.46109495 0.02142524 1.45755796 0.01180199 0.15536712 5.545350 0.12797917 0.01233333 0.282800000 0.2704667 2.663107e-09 2.663107e-09 FALSE TRUE
ENST00000473616 ENSG00000078114 HEK293_OSMI2_2hA HEK293_TMG_2hB NEBL protein_coding protein_coding 2.560019 2.004239 5.161978 0.2553725 0.2292988 1.360481 0.10977993 0.46792899 0.04184604 0.09666510 0.04184604 -3.204491 0.04725833 0.22913333 0.008233333 -0.2209000 3.365710e-05 2.663107e-09 FALSE FALSE
ENST00000498424 ENSG00000078114 HEK293_OSMI2_2hA HEK293_TMG_2hB NEBL protein_coding retained_intron 2.560019 2.004239 5.161978 0.2553725 0.2292988 1.360481 0.02022407 0.16179260 0.00000000 0.16179260 0.00000000 -4.102596 0.00805000 0.06440000 0.000000000 -0.0644000 5.785123e-01 2.663107e-09   FALSE
ENST00000675700 ENSG00000078114 HEK293_OSMI2_2hA HEK293_TMG_2hB NEBL protein_coding processed_transcript 2.560019 2.004239 5.161978 0.2553725 0.2292988 1.360481 1.48953810 1.01320936 3.17934927 0.07912271 0.17595523 1.640161 0.55989583 0.51776667 0.615966667 0.0982000 5.109913e-01 2.663107e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000078114 E001 0.0000000       10 20779973 20780049 77 -      
ENSG00000078114 E002 231.1444787 0.0372687565 8.045506e-02 1.602748e-01 10 20780050 20783905 3856 - 2.250 2.447 0.656
ENSG00000078114 E003 114.8808066 0.0002874333 1.493354e-21 1.133006e-19 10 20783906 20785663 1758 - 2.063 1.797 -0.894
ENSG00000078114 E004 30.7644900 0.0007483520 3.109440e-03 1.058857e-02 10 20785664 20785923 260 - 1.474 1.354 -0.417
ENSG00000078114 E005 20.7346687 0.0009409401 3.271345e-03 1.106572e-02 10 20787202 20787308 107 - 1.322 1.152 -0.599
ENSG00000078114 E006 0.0000000       10 20793333 20793376 44 -      
ENSG00000078114 E007 0.3268771 0.0280503866 4.643799e-01   10 20808510 20808659 150 - 0.071 0.204 1.762
ENSG00000078114 E008 0.1515154 0.0420014690 1.000000e+00   10 20809806 20809866 61 - 0.071 0.000 -10.607
ENSG00000078114 E009 0.1817044 0.0390709328 1.735478e-01   10 20809867 20809898 32 - 0.000 0.204 12.648
ENSG00000078114 E010 22.2236673 0.0014178598 3.301662e-02 7.783598e-02 10 20812769 20812940 172 - 1.336 1.250 -0.302
ENSG00000078114 E011 1.7963936 0.0583623837 1.284192e-03 4.924026e-03 10 20813740 20813938 199 - 0.131 0.766 3.772
ENSG00000078114 E012 2.3132938 0.0091846282 7.743639e-05 4.159250e-04 10 20813939 20814043 105 - 0.185 0.880 3.634
ENSG00000078114 E013 1.8746422 0.0081333665 9.145433e-06 6.133442e-05 10 20815625 20815717 93 - 0.071 0.844 5.082
ENSG00000078114 E014 0.2965864 0.1894931962 6.114557e-02   10 20815718 20815825 108 - 0.000 0.337 12.782
ENSG00000078114 E015 0.0000000       10 20817598 20817599 2 -      
ENSG00000078114 E016 2.4606169 0.0065243810 6.109618e-04 2.573252e-03 10 20817600 20817692 93 - 0.232 0.845 3.085
ENSG00000078114 E017 0.0000000       10 20818318 20818703 386 -      
ENSG00000078114 E018 0.7353121 0.0194553466 3.306039e-01 4.742040e-01 10 20818704 20818834 131 - 0.131 0.343 1.766
ENSG00000078114 E019 1.8811607 0.0121225877 5.195080e-03 1.646109e-02 10 20818835 20819423 589 - 0.185 0.717 2.989
ENSG00000078114 E020 2.1327949 0.0141780538 1.914952e-04 9.274750e-04 10 20819424 20819516 93 - 0.131 0.808 3.939
ENSG00000078114 E021 1.4382703 0.0107325224 3.744845e-02 8.630879e-02 10 20823208 20823300 93 - 0.185 0.602 2.501
ENSG00000078114 E022 1.7306895 0.1093187030 6.052207e-04 2.552476e-03 10 20826447 20826539 93 - 0.071 0.771 4.795
ENSG00000078114 E023 1.9122947 0.0076310456 1.774803e-03 6.518848e-03 10 20828530 20828634 105 - 0.185 0.763 3.177
ENSG00000078114 E024 0.0000000       10 20831146 20831195 50 -      
ENSG00000078114 E025 1.9186374 0.0076827374 1.782122e-03 6.542723e-03 10 20831196 20831306 111 - 0.185 0.763 3.177
ENSG00000078114 E026 2.5369026 0.0076249856 7.121729e-05 3.860565e-04 10 20831473 20831583 111 - 0.185 0.881 3.638
ENSG00000078114 E027 2.3927635 0.0062971510 3.926061e-03 1.293486e-02 10 20835513 20835623 111 - 0.275 0.806 2.610
ENSG00000078114 E028 2.0230251 0.0074630342 2.412924e-02 6.007954e-02 10 20840739 20840849 111 - 0.275 0.716 2.248
ENSG00000078114 E029 2.3949416 0.0222864630 7.832763e-02 1.567918e-01 10 20845258 20845368 111 - 0.350 0.717 1.767
ENSG00000078114 E030 0.0000000       10 20845369 20845495 127 -      
ENSG00000078114 E031 2.3907744 0.2046080707 6.449816e-02 1.342111e-01 10 20850395 20850502 108 - 0.275 0.783 2.518
ENSG00000078114 E032 2.1380949 0.0113518349 2.460185e-02 6.105809e-02 10 20852545 20852649 105 - 0.275 0.716 2.251
ENSG00000078114 E033 1.6533874 0.0104186756 1.257182e-01 2.281731e-01 10 20858240 20858344 105 - 0.275 0.602 1.762
ENSG00000078114 E034 0.0000000       10 20859283 20859712 430 -      
ENSG00000078114 E035 0.9504423 0.2206790762 7.516090e-01 8.379978e-01 10 20859713 20859826 114 - 0.232 0.343 0.771
ENSG00000078114 E036 0.0000000       10 20867759 20868663 905 -      
ENSG00000078114 E037 0.7718584 0.0160155052 5.309541e-01 6.634632e-01 10 20868664 20868765 102 - 0.185 0.342 1.175
ENSG00000078114 E038 1.2963344 0.0113912384 5.183736e-01 6.526157e-01 10 20869740 20869841 102 - 0.275 0.447 1.025
ENSG00000078114 E039 0.8275069 0.6884339050 1.000000e+00 1.000000e+00 10 20880794 20880873 80 - 0.234 0.211 -0.195
ENSG00000078114 E040 0.6330284 0.0202399471 3.337405e-01 4.774847e-01 10 20880874 20880904 31 - 0.131 0.342 1.760
ENSG00000078114 E041 0.7845438 0.0205898587 5.335324e-01 6.657146e-01 10 20888097 20888207 111 - 0.185 0.342 1.174
ENSG00000078114 E042 0.9222279 0.0133983645 2.371414e-01 3.708733e-01 10 20889845 20889949 105 - 0.185 0.446 1.759
ENSG00000078114 E043 1.4642074 0.0097624583 7.390674e-02 1.497579e-01 10 20896958 20897029 72 - 0.232 0.602 2.083
ENSG00000078114 E044 0.0000000       10 20897125 20897311 187 -      
ENSG00000078114 E045 1.6835763 0.1141306380 4.868766e-02 1.068365e-01 10 20899378 20899450 73 - 0.232 0.664 2.357
ENSG00000078114 E046 0.0000000       10 20899451 20899691 241 -      
ENSG00000078114 E047 1.4235111 0.1326062175 8.433775e-01 9.024711e-01 10 20945338 20945425 88 - 0.349 0.345 -0.026
ENSG00000078114 E048 1.4716710 0.0220356882 7.561982e-01 8.413370e-01 10 20957731 20957815 85 - 0.350 0.343 -0.041
ENSG00000078114 E049 1.9092759 0.0093189350 1.924811e-01 3.168773e-01 10 20958846 20958966 121 - 0.314 0.602 1.502
ENSG00000078114 E050 2.0587150 0.0090582740 2.740311e-01 4.131270e-01 10 20959924 20959999 76 - 0.350 0.602 1.279
ENSG00000078114 E051 0.2966881 0.0290785164 6.463013e-01   10 20960000 20960012 13 - 0.131 0.000 -11.651
ENSG00000078114 E052 2.6249236 0.0057511533 7.509798e-01 8.375230e-01 10 20960089 20961671 1583 - 0.518 0.531 0.061
ENSG00000078114 E053 20.0596171 0.0009718415 1.030126e-01 1.950587e-01 10 20961672 20961779 108 - 1.283 1.235 -0.170
ENSG00000078114 E054 0.0000000       10 21002634 21002696 63 -      
ENSG00000078114 E055 18.6191567 0.0010632651 2.071224e-02 5.298090e-02 10 21020117 21020201 85 - 1.271 1.152 -0.423
ENSG00000078114 E056 0.1817044 0.0390709328 1.735478e-01   10 21054224 21054278 55 - 0.000 0.204 12.648
ENSG00000078114 E057 0.1817044 0.0390709328 1.735478e-01   10 21054977 21055033 57 - 0.000 0.204 12.648
ENSG00000078114 E058 0.0000000       10 21100318 21100464 147 -      
ENSG00000078114 E059 0.0000000       10 21101018 21101130 113 -      
ENSG00000078114 E060 0.0000000       10 21125763 21126123 361 -      
ENSG00000078114 E061 0.0000000       10 21126124 21126158 35 -      
ENSG00000078114 E062 0.0000000       10 21126332 21126463 132 -      
ENSG00000078114 E063 0.0000000       10 21146342 21146559 218 -      
ENSG00000078114 E064 1.4424375 0.0094694327 2.662102e-01 4.043805e-01 10 21170262 21170727 466 - 0.275 0.531 1.439
ENSG00000078114 E065 0.7469680 0.0170064239 1.587489e-01 2.734692e-01 10 21171547 21172382 836 - 0.275 0.000 -12.957
ENSG00000078114 E066 15.8920209 0.0012094702 7.575264e-02 1.527087e-01 10 21172383 21172477 95 - 1.195 1.113 -0.291
ENSG00000078114 E067 12.4564179 0.0140793738 1.603892e-02 4.282146e-02 10 21173765 21174187 423 - 1.126 0.913 -0.782
ENSG00000078114 E068 0.1451727 0.0424160594 1.000000e+00   10 21174840 21174931 92 - 0.071 0.000 -10.604
ENSG00000078114 E069 0.0000000       10 21247921 21247989 69 -      
ENSG00000078114 E070 0.0000000       10 21251732 21251828 97 -      
ENSG00000078114 E071 0.0000000       10 21292830 21293011 182 -