ENSG00000078061

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377039 ENSG00000078061 HEK293_OSMI2_2hA HEK293_TMG_2hB ARAF protein_coding protein_coding 34.99806 46.69337 29.2327 2.873595 0.2560928 -0.6754501 3.154539 2.028480 3.740942 0.2283519 0.2391260 0.8797593 0.1027208 0.04396667 0.12810000 0.08413333 1.915023e-06 5.356134e-17 FALSE TRUE
ENST00000377045 ENSG00000078061 HEK293_OSMI2_2hA HEK293_TMG_2hB ARAF protein_coding protein_coding 34.99806 46.69337 29.2327 2.873595 0.2560928 -0.6754501 26.296091 41.213377 18.869108 2.5108836 0.2726516 -1.1266721 0.7223625 0.88276667 0.64543333 -0.23733333 5.356134e-17 5.356134e-17 FALSE TRUE
ENST00000469505 ENSG00000078061 HEK293_OSMI2_2hA HEK293_TMG_2hB ARAF protein_coding processed_transcript 34.99806 46.69337 29.2327 2.873595 0.2560928 -0.6754501 1.751376 1.423404 1.933454 0.1696490 0.3581695 0.4391779 0.0551000 0.03033333 0.06633333 0.03600000 2.598582e-02 5.356134e-17   FALSE
ENST00000489496 ENSG00000078061 HEK293_OSMI2_2hA HEK293_TMG_2hB ARAF protein_coding processed_transcript 34.99806 46.69337 29.2327 2.873595 0.2560928 -0.6754501 3.482386 1.719840 4.495743 0.7800692 0.7050140 1.3811264 0.1105292 0.03636667 0.15346667 0.11710000 5.536322e-02 5.356134e-17 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000078061 E001 0.000000       X 47559458 47559944 487 +      
ENSG00000078061 E002 9.050041 0.0019030752 3.704464e-01 5.148673e-01 X 47559945 47561204 1260 + 1.018 0.917 -0.374
ENSG00000078061 E003 70.463171 0.0023245604 2.424843e-12 5.586516e-11 X 47561205 47561221 17 + 2.011 1.677 -1.125
ENSG00000078061 E004 163.750783 0.0002997692 3.703921e-06 2.717332e-05 X 47561222 47561251 30 + 2.253 2.116 -0.457
ENSG00000078061 E005 332.517468 0.0020747872 1.271276e-03 4.881616e-03 X 47562909 47563051 143 + 2.530 2.440 -0.302
ENSG00000078061 E006 204.048136 0.0027232070 1.574776e-02 4.216711e-02 X 47563052 47563063 12 + 2.313 2.230 -0.277
ENSG00000078061 E007 2.141129 0.0069980574 2.281513e-01 3.602291e-01 X 47563064 47563067 4 + 0.599 0.397 -0.992
ENSG00000078061 E008 366.088185 0.0025546947 3.012753e-04 1.384862e-03 X 47563226 47563329 104 + 2.584 2.478 -0.353
ENSG00000078061 E009 355.178166 0.0002000654 8.474708e-12 1.786081e-10 X 47564797 47564899 103 + 2.590 2.453 -0.457
ENSG00000078061 E010 399.877323 0.0001378304 4.172562e-09 5.511256e-08 X 47564985 47565139 155 + 2.622 2.511 -0.367
ENSG00000078061 E011 12.421845 0.0179127811 1.175469e-05 7.685292e-05 X 47565140 47565233 94 + 1.367 0.884 -1.743
ENSG00000078061 E012 246.226776 0.0002062163 2.920433e-03 1.003113e-02 X 47565252 47565350 99 + 2.385 2.313 -0.240
ENSG00000078061 E013 37.625446 0.0022097956 5.158014e-16 2.023965e-14 X 47565351 47565975 625 + 1.832 1.349 -1.649
ENSG00000078061 E014 127.926700 0.0002755868 8.062805e-01 8.768630e-01 X 47566639 47566688 50 + 2.042 2.052 0.036
ENSG00000078061 E015 202.922057 0.0013515854 3.458756e-01 4.900209e-01 X 47566689 47566780 92 + 2.223 2.258 0.116
ENSG00000078061 E016 167.922791 0.0032020390 5.612162e-01 6.890833e-01 X 47566884 47566911 28 + 2.147 2.176 0.097
ENSG00000078061 E017 335.314878 0.0006154445 5.141765e-01 6.489274e-01 X 47566986 47567131 146 + 2.453 2.472 0.063
ENSG00000078061 E018 502.884728 0.0001522825 5.713755e-01 6.976643e-01 X 47567230 47567432 203 + 2.634 2.647 0.041
ENSG00000078061 E019 589.127557 0.0007726589 5.659407e-01 6.929710e-01 X 47568718 47568894 177 + 2.702 2.718 0.053
ENSG00000078061 E020 379.522576 0.0022176187 4.660271e-01 6.056003e-01 X 47568987 47569033 47 + 2.504 2.531 0.089
ENSG00000078061 E021 17.925714 0.0037551941 3.236803e-07 2.974401e-06 X 47569459 47569538 80 + 1.488 1.060 -1.505
ENSG00000078061 E022 543.477233 0.0005628297 3.615082e-02 8.388282e-02 X 47569539 47569657 119 + 2.644 2.689 0.151
ENSG00000078061 E023 413.389678 0.0002251832 4.011120e-03 1.317409e-02 X 47569893 47569985 93 + 2.511 2.572 0.205
ENSG00000078061 E024 246.901065 0.0002245520 1.167027e-02 3.274869e-02 X 47569986 47570024 39 + 2.282 2.350 0.228
ENSG00000078061 E025 2.485047 0.0092368397 1.887727e-02 4.906423e-02 X 47570025 47570252 228 + 0.737 0.359 -1.798
ENSG00000078061 E026 416.340921 0.0004987924 1.183156e-06 9.676451e-06 X 47570878 47571012 135 + 2.475 2.586 0.372
ENSG00000078061 E027 368.670490 0.0001594760 3.509905e-07 3.201758e-06 X 47571323 47571406 84 + 2.423 2.535 0.375
ENSG00000078061 E028 423.158090 0.0009928752 3.262192e-08 3.647383e-07 X 47571407 47571520 114 + 2.462 2.603 0.470
ENSG00000078061 E029 563.718121 0.0020805844 4.542376e-08 4.941086e-07 X 47571521 47572960 1440 + 2.577 2.731 0.515