ENSG00000078043

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324794 ENSG00000078043 HEK293_OSMI2_2hA HEK293_TMG_2hB PIAS2 protein_coding protein_coding 6.142697 3.053675 9.38024 0.4214383 0.08628079 1.615899 0.6042952 0.29340241 0.9264911 0.02487764 0.05495325 1.6260327 0.09637917 0.10123333 0.09870000 -0.002533333 0.99602903 0.01526696 FALSE TRUE
ENST00000398654 ENSG00000078043 HEK293_OSMI2_2hA HEK293_TMG_2hB PIAS2 protein_coding nonsense_mediated_decay 6.142697 3.053675 9.38024 0.4214383 0.08628079 1.615899 0.5463364 0.00000000 0.8680377 0.00000000 0.44026222 6.4562110 0.06972500 0.00000000 0.09326667 0.093266667 0.33897686 0.01526696 FALSE TRUE
ENST00000585916 ENSG00000078043 HEK293_OSMI2_2hA HEK293_TMG_2hB PIAS2 protein_coding protein_coding 6.142697 3.053675 9.38024 0.4214383 0.08628079 1.615899 0.4579536 0.34304262 0.5962143 0.11559019 0.04604272 0.7799855 0.08602500 0.10666667 0.06353333 -0.043133333 0.19592924 0.01526696 FALSE TRUE
MSTRG.15770.2 ENSG00000078043 HEK293_OSMI2_2hA HEK293_TMG_2hB PIAS2 protein_coding   6.142697 3.053675 9.38024 0.4214383 0.08628079 1.615899 1.5682092 1.32299883 2.1645228 0.19034863 0.30829549 0.7060233 0.27067500 0.43496667 0.23043333 -0.204533333 0.01526696 0.01526696 FALSE TRUE
MSTRG.15770.3 ENSG00000078043 HEK293_OSMI2_2hA HEK293_TMG_2hB PIAS2 protein_coding   6.142697 3.053675 9.38024 0.4214383 0.08628079 1.615899 1.0730132 0.69418237 2.0278452 0.10080400 0.20214168 1.5330235 0.17128333 0.24330000 0.21616667 -0.027133333 0.95658942 0.01526696 TRUE TRUE
MSTRG.15770.4 ENSG00000078043 HEK293_OSMI2_2hA HEK293_TMG_2hB PIAS2 protein_coding   6.142697 3.053675 9.38024 0.4214383 0.08628079 1.615899 0.4267877 0.06028547 0.4434512 0.06028547 0.22339145 2.6896490 0.06863333 0.01546667 0.04686667 0.031400000 0.76858287 0.01526696 FALSE TRUE
MSTRG.15770.8 ENSG00000078043 HEK293_OSMI2_2hA HEK293_TMG_2hB PIAS2 protein_coding   6.142697 3.053675 9.38024 0.4214383 0.08628079 1.615899 0.7083191 0.00000000 1.0923175 0.00000000 0.56660034 6.7843961 0.10086667 0.00000000 0.11696667 0.116966667 0.33203469 0.01526696 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000078043 E001 104.3019437 0.0194186268 0.0110304606 0.031235055 18 46803218 46811810 8593 - 1.918 2.133 0.721
ENSG00000078043 E002 33.2989863 0.0006492392 0.0211908560 0.054000297 18 46811811 46812247 437 - 1.463 1.620 0.538
ENSG00000078043 E003 18.6252497 0.0047819524 0.3581115648 0.502493550 18 46812248 46812279 32 - 1.241 1.334 0.324
ENSG00000078043 E004 16.0983580 0.0074462160 0.3493027519 0.493521758 18 46812280 46812290 11 - 1.179 1.280 0.355
ENSG00000078043 E005 27.3226000 0.0008366571 0.1884638461 0.311797312 18 46812291 46812426 136 - 1.395 1.500 0.365
ENSG00000078043 E006 44.2997130 0.0091265090 0.8998948026 0.940138303 18 46812427 46812586 160 - 1.629 1.652 0.079
ENSG00000078043 E007 22.4679286 0.0010074941 0.3571531640 0.501563709 18 46812587 46812612 26 - 1.323 1.408 0.299
ENSG00000078043 E008 1.3402425 0.0154147956 0.5835613233 0.707656257 18 46812613 46812615 3 - 0.394 0.302 -0.556
ENSG00000078043 E009 26.9186334 0.0066747335 0.5693647312 0.695931043 18 46815312 46815349 38 - 1.406 1.470 0.221
ENSG00000078043 E010 37.8176674 0.0011863103 0.2695130276 0.408014649 18 46815711 46818190 2480 - 1.581 1.527 -0.182
ENSG00000078043 E011 2.4505941 0.0062816821 0.0951763277 0.183140802 18 46818191 46818277 87 - 0.597 0.302 -1.553
ENSG00000078043 E012 6.2880765 0.0027486279 0.4592581232 0.599480988 18 46818278 46818375 98 - 0.865 0.780 -0.330
ENSG00000078043 E013 14.0298769 0.0014479308 0.9986675905 1.000000000 18 46818376 46818447 72 - 1.148 1.164 0.055
ENSG00000078043 E014 60.1425810 0.0003936289 0.2237730950 0.354923616 18 46820933 46821072 140 - 1.741 1.815 0.248
ENSG00000078043 E015 4.9908236 0.0035153796 0.5071450226 0.642746493 18 46826764 46827757 994 - 0.782 0.701 -0.330
ENSG00000078043 E016 3.5970209 0.0954279496 0.4234772258 0.566527247 18 46827758 46827958 201 - 0.595 0.739 0.609
ENSG00000078043 E017 65.4266028 0.0005635252 0.1705142559 0.288820470 18 46827959 46828130 172 - 1.775 1.853 0.264
ENSG00000078043 E018 48.7375378 0.0005058270 0.4298515602 0.572515896 18 46829734 46829867 134 - 1.685 1.660 -0.084
ENSG00000078043 E019 0.3030308 0.3914040617 0.6944132730   18 46836243 46836356 114 - 0.153 0.000 -10.806
ENSG00000078043 E020 59.1706051 0.0003946405 0.8092931668 0.878901203 18 46836357 46836517 161 - 1.759 1.765 0.021
ENSG00000078043 E021 0.2998086 0.0279393288 0.5417733094   18 46843851 46844053 203 - 0.083 0.177 1.252
ENSG00000078043 E022 42.3354678 0.0061820331 0.8921659871 0.935115273 18 46844054 46844127 74 - 1.609 1.638 0.098
ENSG00000078043 E023 43.2278064 0.0005696274 0.3793219588 0.523584195 18 46844734 46844839 106 - 1.604 1.669 0.222
ENSG00000078043 E024 0.1472490 0.0451125936 1.0000000000   18 46844840 46844971 132 - 0.083 0.000 -9.798
ENSG00000078043 E025 0.0000000       18 46846464 46846706 243 -      
ENSG00000078043 E026 47.7303276 0.0005679176 0.6249382915 0.741149382 18 46846707 46846841 135 - 1.673 1.665 -0.029
ENSG00000078043 E027 33.4938289 0.0014605389 0.0819823408 0.162655927 18 46855345 46855435 91 - 1.548 1.449 -0.340
ENSG00000078043 E028 29.9997836 0.0108191759 0.1300175126 0.234194701 18 46855565 46855615 51 - 1.507 1.390 -0.405
ENSG00000078043 E029 38.9645522 0.0006619864 0.1429015467 0.251984138 18 46864164 46864248 85 - 1.599 1.527 -0.246
ENSG00000078043 E030 45.6825328 0.0021078377 0.0018833007 0.006862847 18 46890580 46890685 106 - 1.696 1.521 -0.597
ENSG00000078043 E031 42.7262924 0.0006446216 0.0006372872 0.002670829 18 46890686 46890808 123 - 1.673 1.486 -0.638
ENSG00000078043 E032 30.0724713 0.0007426477 0.1178861636 0.216898588 18 46890809 46890893 85 - 1.499 1.409 -0.311
ENSG00000078043 E033 30.6867670 0.0023207192 0.4837245718 0.621744525 18 46890894 46891031 138 - 1.490 1.457 -0.114
ENSG00000078043 E034 16.4654844 0.0011457435 0.1861077548 0.308865664 18 46891032 46891054 23 - 1.252 1.148 -0.367
ENSG00000078043 E035 0.0000000       18 46893431 46893531 101 -      
ENSG00000078043 E036 6.7871961 0.0025253313 0.2628478178 0.400664053 18 46903527 46903633 107 - 0.912 0.780 -0.511
ENSG00000078043 E037 2.7282541 0.0053872610 0.0539950181 0.116258018 18 46903634 46903635 2 - 0.641 0.302 -1.745
ENSG00000078043 E038 0.2955422 0.0281461102 0.5422100934   18 46904102 46904206 105 - 0.083 0.177 1.252
ENSG00000078043 E039 0.5159433 0.2829551378 0.8485631431 0.905973455 18 46905760 46906226 467 - 0.153 0.180 0.283
ENSG00000078043 E040 1.1907914 0.2671428490 0.0909091946 0.176582806 18 46906227 46906315 89 - 0.430 0.000 -12.802
ENSG00000078043 E041 0.0000000       18 46907498 46907559 62 -      
ENSG00000078043 E042 0.0000000       18 46907658 46907999 342 -      
ENSG00000078043 E043 0.0000000       18 46916829 46917321 493 -      
ENSG00000078043 E044 18.4267407 0.0010513387 0.0126254570 0.035027018 18 46917322 46917507 186 - 1.323 1.116 -0.730
ENSG00000078043 E045 0.1472490 0.0451125936 1.0000000000   18 46918002 46918041 40 - 0.083 0.000 -9.798
ENSG00000078043 E046 0.0000000       18 46920059 46920160 102 -