ENSG00000077942

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262722 ENSG00000077942 HEK293_OSMI2_2hA HEK293_TMG_2hB FBLN1 protein_coding protein_coding 40.15318 61.17962 31.53329 1.749091 0.5513088 -0.955954 26.051521 41.2109195 17.670017 0.9949015 0.5272300 -1.2212570 0.64077917 0.6738 0.5609 -0.1129 0.003120445 0.000326728 FALSE TRUE
ENST00000327858 ENSG00000077942 HEK293_OSMI2_2hA HEK293_TMG_2hB FBLN1 protein_coding protein_coding 40.15318 61.17962 31.53329 1.749091 0.5513088 -0.955954 10.551331 15.7855264 9.315518 0.3696965 0.2593493 -0.7602602 0.26938333 0.2581 0.2956 0.0375 0.212419890 0.000326728 FALSE TRUE
ENST00000455233 ENSG00000077942 HEK293_OSMI2_2hA HEK293_TMG_2hB FBLN1 protein_coding protein_coding 40.15318 61.17962 31.53329 1.749091 0.5513088 -0.955954 1.167125 0.4360133 2.892233 0.3030803 0.4220313 2.7020050 0.02978333 0.0070 0.0913 0.0843 0.000326728 0.000326728 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000077942 E001 0.0000000       22 45502238 45502276 39 +      
ENSG00000077942 E002 0.0000000       22 45502277 45502340 64 +      
ENSG00000077942 E003 0.0000000       22 45502341 45502488 148 +      
ENSG00000077942 E004 8.6559809 0.0991156457 4.760971e-06 3.406291e-05 22 45502832 45502882 51 + 1.356 0.536 -3.156
ENSG00000077942 E005 31.7211864 0.0470552524 1.757712e-14 5.588072e-13 22 45502883 45502969 87 + 1.917 0.962 -3.323
ENSG00000077942 E006 26.9799274 0.0340422459 1.094794e-13 3.093294e-12 22 45502970 45502975 6 + 1.818 0.984 -2.909
ENSG00000077942 E007 61.5669315 0.0109814122 6.472842e-10 9.946954e-09 22 45502976 45503045 70 + 2.000 1.586 -1.399
ENSG00000077942 E008 57.1818730 0.0039162761 1.576283e-05 1.000845e-04 22 45503046 45503064 19 + 1.870 1.630 -0.809
ENSG00000077942 E009 1.2867680 0.0672882861 8.756871e-01 9.241496e-01 22 45503065 45503490 426 + 0.293 0.325 0.213
ENSG00000077942 E010 0.0000000       22 45517345 45517640 296 +      
ENSG00000077942 E011 0.1451727 0.0425410377 2.238297e-01   22 45517641 45517698 58 + 0.170 0.000 -12.390
ENSG00000077942 E012 0.2214452 0.0388496915 1.000000e+00   22 45518582 45518681 100 + 0.000 0.087 9.869
ENSG00000077942 E013 191.8252048 0.0014279631 1.334926e-06 1.079053e-05 22 45518682 45518782 101 + 2.337 2.185 -0.506
ENSG00000077942 E014 127.8293684 0.0018232708 6.403573e-02 1.334115e-01 22 45518783 45518787 5 + 2.107 2.037 -0.233
ENSG00000077942 E015 0.1451727 0.0425410377 2.238297e-01   22 45523091 45523204 114 + 0.170 0.000 -12.390
ENSG00000077942 E016 316.0233428 0.0016482623 1.665229e-02 4.417456e-02 22 45525543 45525674 132 + 2.495 2.431 -0.216
ENSG00000077942 E017 178.4021016 0.0022588036 1.703166e-02 4.500509e-02 22 45525675 45525678 4 + 2.261 2.178 -0.277
ENSG00000077942 E018 424.9895029 0.0006354781 6.218132e-05 3.422249e-04 22 45527847 45528009 163 + 2.637 2.554 -0.274
ENSG00000077942 E019 252.9782442 0.0007344559 2.101790e-03 7.539484e-03 22 45531265 45531324 60 + 2.410 2.331 -0.264
ENSG00000077942 E020 0.9672673 0.0143452366 7.990468e-02 1.594164e-01 22 45532893 45533062 170 + 0.466 0.159 -2.125
ENSG00000077942 E021 281.9889818 0.0009828024 2.384171e-01 3.722998e-01 22 45533063 45533150 88 + 2.423 2.394 -0.096
ENSG00000077942 E022 135.6367248 0.0005521053 6.476447e-01 7.592810e-01 22 45533151 45533164 14 + 2.095 2.082 -0.045
ENSG00000077942 E023 157.1854026 0.0002192486 5.791966e-01 7.041459e-01 22 45533761 45533780 20 + 2.160 2.146 -0.050
ENSG00000077942 E024 306.6617602 0.0005526829 9.624758e-01 9.803337e-01 22 45533781 45533898 118 + 2.438 2.440 0.005
ENSG00000077942 E025 226.8513536 0.0002063187 1.554727e-01 2.690240e-01 22 45535200 45535255 56 + 2.280 2.319 0.133
ENSG00000077942 E026 323.1493871 0.0001783920 3.042952e-01 4.463114e-01 22 45535256 45535337 82 + 2.442 2.466 0.083
ENSG00000077942 E027 15.2487761 0.0011598564 2.800613e-02 6.802587e-02 22 45535338 45535584 247 + 0.985 1.210 0.814
ENSG00000077942 E028 463.0446453 0.0007032448 7.503763e-01 8.370667e-01 22 45541229 45541372 144 + 2.610 2.619 0.032
ENSG00000077942 E029 438.4898311 0.0001540300 2.518568e-01 3.881483e-01 22 45542155 45542283 129 + 2.574 2.598 0.080
ENSG00000077942 E030 387.2978605 0.0001428301 1.642882e-02 4.367776e-02 22 45543401 45543526 126 + 2.501 2.551 0.169
ENSG00000077942 E031 382.8824119 0.0006631346 3.679024e-07 3.342349e-06 22 45547085 45547204 120 + 2.442 2.565 0.409
ENSG00000077942 E032 403.7134677 0.0017092931 5.944866e-05 3.287132e-04 22 45548613 45548744 132 + 2.472 2.587 0.383
ENSG00000077942 E033 435.0229476 0.0019285265 1.231943e-05 8.015247e-05 22 45550492 45550615 124 + 2.495 2.622 0.422
ENSG00000077942 E034 0.4428904 0.4560876832 6.305501e-01 7.457227e-01 22 45550901 45551129 229 + 0.000 0.166 10.940
ENSG00000077942 E035 2.1682109 0.0724595931 3.203212e-01 4.634198e-01 22 45558071 45558711 641 + 0.589 0.407 -0.896
ENSG00000077942 E036 512.5802860 0.0024764253 3.254986e-15 1.151321e-13 22 45562912 45563362 451 + 2.476 2.715 0.796
ENSG00000077942 E037 2.7721660 0.1021679505 7.230049e-01 8.169436e-01 22 45564884 45565701 818 + 0.466 0.543 0.371
ENSG00000077942 E038 112.0087161 0.0002893157 1.383727e-04 6.964108e-04 22 45574511 45574653 143 + 2.094 1.961 -0.445
ENSG00000077942 E039 88.6817637 0.0003147967 5.931685e-04 2.508684e-03 22 45576977 45577038 62 + 1.996 1.862 -0.449
ENSG00000077942 E040 107.0872046 0.0002862289 3.063355e-04 1.405122e-03 22 45577039 45577108 70 + 2.073 1.945 -0.430
ENSG00000077942 E041 0.1817044 0.0393309685 1.000000e+00   22 45577906 45578434 529 + 0.000 0.087 9.866
ENSG00000077942 E042 342.0493886 0.0010374423 4.315601e-03 1.402844e-02 22 45600307 45601135 829 + 2.429 2.506 0.258