ENSG00000077684

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000413543 ENSG00000077684 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE1 protein_coding protein_coding 10.59519 7.033177 11.65192 0.4835682 0.9078785 0.7275076 0.8014832 2.0776992 0.06493721 0.9021028 0.06493721 -4.8000878 0.10609583 0.2963333 0.00490000 -0.29143333 0.006600174 0.006600174 FALSE TRUE
ENST00000511647 ENSG00000077684 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE1 protein_coding protein_coding 10.59519 7.033177 11.65192 0.4835682 0.9078785 0.7275076 2.9197685 2.1250808 2.54281910 0.9153755 0.07455076 0.2578006 0.29447083 0.3001000 0.22146667 -0.07863333 0.863552838 0.006600174 FALSE TRUE
ENST00000512960 ENSG00000077684 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE1 protein_coding protein_coding 10.59519 7.033177 11.65192 0.4835682 0.9078785 0.7275076 0.6687471 0.6449843 0.92916501 0.1174066 0.10057850 0.5199183 0.06238750 0.0948000 0.08083333 -0.01396667 0.880355039 0.006600174 FALSE TRUE
ENST00000610919 ENSG00000077684 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE1 protein_coding protein_coding 10.59519 7.033177 11.65192 0.4835682 0.9078785 0.7275076 3.7770468 1.9419703 4.69679880 0.1299678 0.65860655 1.2698151 0.33779167 0.2764333 0.40190000 0.12546667 0.148712111 0.006600174 FALSE TRUE
MSTRG.25460.16 ENSG00000077684 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE1 protein_coding   10.59519 7.033177 11.65192 0.4835682 0.9078785 0.7275076 0.8156809 0.0000000 0.65084861 0.0000000 0.32625219 6.0462479 0.06648333 0.0000000 0.05620000 0.05620000 0.248759268 0.006600174 FALSE TRUE
MSTRG.25460.9 ENSG00000077684 HEK293_OSMI2_2hA HEK293_TMG_2hB JADE1 protein_coding   10.59519 7.033177 11.65192 0.4835682 0.9078785 0.7275076 0.4342969 0.0000000 0.85137893 0.0000000 0.44112111 6.4285761 0.03083750 0.0000000 0.06823333 0.06823333 0.230311767 0.006600174 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000077684 E001 0.2955422 0.0291618166 7.762913e-01   4 128809700 128809702 3 + 0.102 0.145 0.581
ENSG00000077684 E002 4.2114922 0.0037095577 2.975104e-03 1.018881e-02 4 128809703 128809814 112 + 0.868 0.414 -2.002
ENSG00000077684 E003 4.8412839 0.0034678333 9.591378e-02 1.842633e-01 4 128809815 128809843 29 + 0.852 0.622 -0.940
ENSG00000077684 E004 7.3094171 0.0025179225 4.521283e-01 5.930152e-01 4 128809844 128809877 34 + 0.953 0.868 -0.323
ENSG00000077684 E005 0.0000000       4 128809919 128809919 1 +      
ENSG00000077684 E006 0.2955422 0.0291618166 7.762913e-01   4 128809920 128810030 111 + 0.102 0.145 0.581
ENSG00000077684 E007 0.2955422 0.0291618166 7.762913e-01   4 128810031 128810088 58 + 0.102 0.145 0.581
ENSG00000077684 E008 7.8856990 0.0024167441 8.359994e-01 8.974556e-01 4 128810089 128810291 203 + 0.953 0.933 -0.075
ENSG00000077684 E009 0.0000000       4 128810292 128810386 95 +      
ENSG00000077684 E010 0.0000000       4 128811028 128811056 29 +      
ENSG00000077684 E011 0.0000000       4 128811270 128811270 1 +      
ENSG00000077684 E012 0.4375944 0.0261156588 1.672228e-01 2.845940e-01 4 128811271 128811287 17 + 0.255 0.000 -10.871
ENSG00000077684 E013 0.6192988 0.0210198411 5.325477e-01 6.648999e-01 4 128811288 128811291 4 + 0.255 0.146 -1.000
ENSG00000077684 E014 4.8269034 0.0533178324 1.216737e-02 3.393104e-02 4 128811292 128811325 34 + 0.913 0.474 -1.863
ENSG00000077684 E015 10.3447544 0.0016445368 4.446783e-02 9.923387e-02 4 128811326 128811396 71 + 1.139 0.933 -0.754
ENSG00000077684 E016 0.5911862 0.0172671820 8.681075e-02 1.702947e-01 4 128811397 128811403 7 + 0.315 0.000 -11.400
ENSG00000077684 E017 0.6213751 0.0247616988 5.328972e-01 6.651806e-01 4 128811806 128811841 36 + 0.255 0.146 -1.000
ENSG00000077684 E018 0.3268771 0.0293666012 7.717559e-01   4 128811844 128811974 131 + 0.102 0.146 0.585
ENSG00000077684 E019 1.9896259 0.0073966316 1.611225e-02 4.298634e-02 4 128816367 128816463 97 + 0.255 0.661 2.168
ENSG00000077684 E020 0.4762024 0.2388752296 8.689482e-01 9.197809e-01 4 128831433 128831553 121 + 0.185 0.146 -0.411
ENSG00000077684 E021 41.8507009 0.0011801887 1.313435e-02 3.621927e-02 4 128831733 128831810 78 + 1.684 1.547 -0.465
ENSG00000077684 E022 0.5870335 0.1195697825 1.114060e-01 2.076152e-01 4 128831811 128831811 1 + 0.314 0.000 -10.682
ENSG00000077684 E023 48.2789608 0.0031606524 1.128176e-01 2.096539e-01 4 128842953 128843038 86 + 1.727 1.640 -0.296
ENSG00000077684 E024 65.0866014 0.0030892154 2.835594e-01 4.237020e-01 4 128846375 128846532 158 + 1.841 1.789 -0.174
ENSG00000077684 E025 39.2685765 0.0013786431 8.327145e-02 1.646909e-01 4 128848980 128849015 36 + 1.644 1.547 -0.330
ENSG00000077684 E026 84.2225964 0.0003057809 8.001701e-04 3.260277e-03 4 128849016 128849167 152 + 1.982 1.857 -0.421
ENSG00000077684 E027 104.5736332 0.0002654560 1.358079e-02 3.726270e-02 4 128852057 128852268 212 + 2.058 1.978 -0.269
ENSG00000077684 E028 77.4982492 0.0009205903 5.297720e-01 6.624986e-01 4 128855630 128855797 168 + 1.881 1.911 0.102
ENSG00000077684 E029 64.1595666 0.0016717626 6.075288e-01 7.274837e-01 4 128857338 128857454 117 + 1.801 1.829 0.096
ENSG00000077684 E030 101.4074684 0.0003438776 3.901358e-01 5.341519e-01 4 128861704 128861958 255 + 1.995 2.029 0.115
ENSG00000077684 E031 108.3531110 0.0003020179 1.045866e-05 6.922334e-05 4 128861959 128862225 267 + 1.966 2.117 0.506
ENSG00000077684 E032 245.2566606 0.0009415965 1.900120e-92 4.615026e-89 4 128862226 128864630 2405 + 2.088 2.605 1.726
ENSG00000077684 E033 27.3554442 0.0007260091 1.899998e-06 1.485550e-05 4 128867856 128867973 118 + 1.570 1.239 -1.146
ENSG00000077684 E034 489.0047982 0.0005247743 2.639410e-32 5.203208e-30 4 128871355 128875224 3870 + 2.761 2.576 -0.615