ENSG00000077463

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-6 / 6
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000337491	ENSG00000077463	HEK293_OSMI2_2hA	HEK293_TMG_2hB	SIRT6	protein_coding	protein_coding	35.80876	58.52309	21.87284	5.232591	0.8794389	-1.419453	18.674499	34.3397096	8.308360	0.6374674	0.2327043	-2.04592682	0.49122500	0.59463333	0.38023333	-0.21440000	2.310511e-03	2.812013e-08	FALSE	TRUE
ENST00000594341	ENSG00000077463	HEK293_OSMI2_2hA	HEK293_TMG_2hB	SIRT6	protein_coding	retained_intron	35.80876	58.52309	21.87284	5.232591	0.8794389	-1.419453	2.272812	2.1630488	2.063767	1.1266120	0.2154828	-0.06746682	0.07330000	0.03393333	0.09426667	0.06033333	5.408130e-01	2.812013e-08	FALSE	FALSE
ENST00000596298	ENSG00000077463	HEK293_OSMI2_2hA	HEK293_TMG_2hB	SIRT6	protein_coding	retained_intron	35.80876	58.52309	21.87284	5.232591	0.8794389	-1.419453	1.817238	2.7798982	2.111569	1.5096799	0.3613624	-0.39508098	0.05178750	0.04343333	0.09653333	0.05310000	6.424004e-01	2.812013e-08	FALSE	TRUE
ENST00000599394	ENSG00000077463	HEK293_OSMI2_2hA	HEK293_TMG_2hB	SIRT6	protein_coding	retained_intron	35.80876	58.52309	21.87284	5.232591	0.8794389	-1.419453	2.443168	1.6552430	2.808615	0.3149393	0.4257602	0.75925390	0.08601250	0.02780000	0.12810000	0.10030000	2.812013e-08	2.812013e-08	FALSE	FALSE
ENST00000601069	ENSG00000077463	HEK293_OSMI2_2hA	HEK293_TMG_2hB	SIRT6	protein_coding	retained_intron	35.80876	58.52309	21.87284	5.232591	0.8794389	-1.419453	1.848530	0.9874545	2.037740	0.0920635	0.5007217	1.03770960	0.06225833	0.01686667	0.09230000	0.07543333	1.393935e-05	2.812013e-08	TRUE	TRUE
ENST00000601571	ENSG00000077463	HEK293_OSMI2_2hA	HEK293_TMG_2hB	SIRT6	protein_coding	protein_coding	35.80876	58.52309	21.87284	5.232591	0.8794389	-1.419453	3.100127	5.9211252	1.592102	0.4258135	0.3473384	-1.88834026	0.08395417	0.10160000	0.07310000	-0.02850000	4.089327e-01	2.812013e-08	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 26
Columns:
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000077463	E001	1.326320	0.0243891240	1.131753e-01	2.101581e-01	19	4174109	4174109	1	-	0.001	0.369	9.342
ENSG00000077463	E002	20.471993	0.0097673866	3.325113e-01	4.761756e-01	19	4174110	4174140	31	-	1.134	1.245	0.396
ENSG00000077463	E003	293.006182	0.0029891070	7.850536e-03	2.340705e-02	19	4174141	4174335	195	-	2.265	2.372	0.358
ENSG00000077463	E004	438.122920	0.0017714897	3.030820e-04	1.392018e-03	19	4174336	4174619	284	-	2.435	2.546	0.371
ENSG00000077463	E005	94.643282	0.0019238968	2.576451e-02	6.345649e-02	19	4174620	4174635	16	-	1.762	1.886	0.420
ENSG00000077463	E006	120.499005	0.0017015714	1.104185e-02	3.126078e-02	19	4174636	4174703	68	-	1.863	1.990	0.427
ENSG00000077463	E007	118.695497	0.0002708704	9.827612e-03	2.833980e-02	19	4174704	4174860	157	-	1.859	1.977	0.399
ENSG00000077463	E008	39.011401	0.0007214948	2.083648e-01	3.365168e-01	19	4174861	4174877	17	-	1.397	1.497	0.345
ENSG00000077463	E009	131.348854	0.0041019862	4.316873e-01	5.742302e-01	19	4174878	4174946	69	-	1.963	2.013	0.169
ENSG00000077463	E010	27.105643	0.0134879243	6.072631e-01	7.272807e-01	19	4174947	4175027	81	-	1.285	1.345	0.210
ENSG00000077463	E011	176.540148	0.0041873453	4.199684e-01	5.632201e-01	19	4175028	4175111	84	-	2.093	2.140	0.156
ENSG00000077463	E012	154.320838	0.0002268509	5.570786e-01	6.855715e-01	19	4175112	4175151	40	-	2.084	2.071	-0.045
ENSG00000077463	E013	62.067445	0.0003815937	4.421792e-12	9.743374e-11	19	4175152	4175571	420	-	1.932	1.602	-1.117
ENSG00000077463	E014	25.545160	0.0037806358	5.644017e-07	4.943557e-06	19	4175572	4175679	108	-	1.589	1.209	-1.319
ENSG00000077463	E015	243.776542	0.0002184027	2.924489e-01	4.334126e-01	19	4175680	4175760	81	-	2.289	2.267	-0.073
ENSG00000077463	E016	7.611733	0.0228520755	1.852741e-03	6.766844e-03	19	4175761	4175790	30	-	1.134	0.718	-1.577
ENSG00000077463	E017	9.471063	0.0448529577	5.213401e-03	1.651200e-02	19	4175791	4175841	51	-	1.208	0.808	-1.480
ENSG00000077463	E018	271.526709	0.0020151204	7.609932e-01	8.449449e-01	19	4175842	4175937	96	-	2.318	2.318	0.000
ENSG00000077463	E019	219.875487	0.0004554329	3.319780e-01	4.755989e-01	19	4177079	4177138	60	-	2.242	2.220	-0.072
ENSG00000077463	E020	352.475688	0.0012203116	2.794362e-01	4.191913e-01	19	4179104	4179286	183	-	2.397	2.437	0.134
ENSG00000077463	E021	20.077066	0.0023042124	5.288069e-20	3.356143e-18	19	4179287	4179503	217	-	1.678	0.966	-2.502
ENSG00000077463	E022	16.460742	0.0011089060	8.571726e-06	5.783900e-05	19	4180580	4180611	32	-	1.419	1.031	-1.373
ENSG00000077463	E023	32.862662	0.0006643307	2.955999e-07	2.739215e-06	19	4180612	4180781	170	-	1.667	1.336	-1.136
ENSG00000077463	E024	281.934852	0.0001784601	1.202594e-01	2.203577e-01	19	4180782	4180909	128	-	2.359	2.327	-0.108
ENSG00000077463	E025	4.250120	0.0076155969	1.291701e-03	4.947946e-03	19	4182211	4182473	263	-	0.964	0.503	-1.910
ENSG00000077463	E026	188.624547	0.0002402033	6.722042e-01	7.782576e-01	19	4182474	4182566	93	-	2.163	2.157	-0.020

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000077463

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3