ENSG00000077380

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340296 ENSG00000077380 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC1I2 protein_coding protein_coding 25.92537 9.474424 43.05853 1.159097 0.8840784 2.183002 7.798805 3.567781 12.175294 0.7768522 0.4890047 1.768004 0.3150458 0.3691667 0.2825667 -0.08660000 2.119164e-01 4.88903e-16 FALSE TRUE
ENST00000409197 ENSG00000077380 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC1I2 protein_coding protein_coding 25.92537 9.474424 43.05853 1.159097 0.8840784 2.183002 5.117086 1.971087 8.959575 0.2177635 0.2356074 2.178747 0.2220042 0.2189000 0.2083667 -0.01053333 1.000000e+00 4.88903e-16 FALSE TRUE
ENST00000435234 ENSG00000077380 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC1I2 protein_coding protein_coding 25.92537 9.474424 43.05853 1.159097 0.8840784 2.183002 9.870851 2.983112 15.886167 0.8621449 0.8080581 2.408961 0.3526792 0.3048000 0.3685667 0.06376667 6.950972e-01 4.88903e-16 FALSE TRUE
ENST00000452242 ENSG00000077380 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC1I2 protein_coding protein_coding 25.92537 9.474424 43.05853 1.159097 0.8840784 2.183002 1.376079 0.000000 3.383891 0.0000000 0.2932469 8.406796 0.0314375 0.0000000 0.0784000 0.07840000 4.889030e-16 4.88903e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000077380 E001 4.0695392 0.0040004795 0.9043422895 0.943090684 2 171687409 171687468 60 + 0.650 0.669 0.082
ENSG00000077380 E002 5.5517202 0.0030079650 0.6994572215 0.799195448 2 171687469 171687470 2 + 0.780 0.722 -0.232
ENSG00000077380 E003 5.8547510 0.0029402368 0.5805787599 0.705287440 2 171687471 171687471 1 + 0.804 0.722 -0.329
ENSG00000077380 E004 31.7774171 0.0006685089 0.1089148750 0.203937656 2 171687472 171687500 29 + 1.491 1.373 -0.408
ENSG00000077380 E005 82.7990306 0.0003436357 0.0023474781 0.008299239 2 171687501 171687627 127 + 1.901 1.757 -0.485
ENSG00000077380 E006 0.5901540 0.0199599351 0.9074006571 0.945199247 2 171687672 171687704 33 + 0.182 0.207 0.232
ENSG00000077380 E007 0.6266857 0.0168821602 0.2245925879 0.355944857 2 171687705 171687707 3 + 0.129 0.347 1.817
ENSG00000077380 E008 2.1830628 0.0066184811 0.5769713758 0.702319506 2 171687708 171687743 36 + 0.437 0.537 0.496
ENSG00000077380 E009 4.8038218 0.0033489943 0.7129454342 0.809524866 2 171687744 171687754 11 + 0.727 0.669 -0.240
ENSG00000077380 E010 15.3692573 0.0012759963 0.2321123034 0.364945221 2 171687755 171687775 21 + 1.182 1.057 -0.451
ENSG00000077380 E011 25.0414089 0.0069848578 0.0987718701 0.188610367 2 171687776 171687791 16 + 1.390 1.229 -0.564
ENSG00000077380 E012 49.1901379 0.0056921101 0.0215010366 0.054644454 2 171687792 171687873 82 + 1.679 1.508 -0.584
ENSG00000077380 E013 1.3253550 0.1382945329 0.1088986057 0.203913239 2 171687881 171688003 123 + 0.408 0.000 -11.927
ENSG00000077380 E014 0.1472490 0.0444184657 1.0000000000   2 171688006 171688010 5 + 0.069 0.000 -8.759
ENSG00000077380 E015 0.2987644 0.0274310194 1.0000000000   2 171688011 171688166 156 + 0.129 0.000 -9.759
ENSG00000077380 E016 0.0000000       2 171688303 171688309 7 +      
ENSG00000077380 E017 0.0000000       2 171688310 171688358 49 +      
ENSG00000077380 E018 0.4783925 0.0216308394 0.6339104291 0.748514588 2 171688471 171688648 178 + 0.129 0.207 0.819
ENSG00000077380 E019 0.0000000       2 171690145 171690146 2 +      
ENSG00000077380 E020 155.1610687 0.0002741196 0.0008013014 0.003264184 2 171690147 171690263 117 + 2.163 2.048 -0.388
ENSG00000077380 E021 150.2154756 0.0002980177 0.7664358634 0.848923199 2 171692777 171692894 118 + 2.127 2.118 -0.031
ENSG00000077380 E022 0.0000000       2 171692895 171693084 190 +      
ENSG00000077380 E023 0.0000000       2 171706547 171706564 18 +      
ENSG00000077380 E024 0.0000000       2 171706890 171707232 343 +      
ENSG00000077380 E025 0.0000000       2 171707233 171707286 54 +      
ENSG00000077380 E026 147.5270580 0.0029170747 0.8115836076 0.880427890 2 171707287 171707377 91 + 2.118 2.114 -0.015
ENSG00000077380 E027 0.3666179 0.0325587645 0.3525587990 0.496816294 2 171712402 171712766 365 + 0.069 0.208 1.822
ENSG00000077380 E028 4.9928999 0.0033295914 0.7016673554 0.800734321 2 171712767 171712826 60 + 0.713 0.770 0.233
ENSG00000077380 E029 159.9254132 0.0002103737 0.4123921546 0.555945438 2 171715328 171715389 62 + 2.158 2.132 -0.087
ENSG00000077380 E030 164.6954050 0.0002059134 0.3272304058 0.470676628 2 171715390 171715443 54 + 2.171 2.139 -0.104
ENSG00000077380 E031 239.7144449 0.0001849055 0.1027835079 0.194739746 2 171725618 171725713 96 + 2.336 2.293 -0.144
ENSG00000077380 E032 256.1778549 0.0001739938 0.6514731433 0.762352980 2 171725919 171726081 163 + 2.357 2.345 -0.037
ENSG00000077380 E033 0.8836199 0.1185806194 0.5860904079 0.709716834 2 171726082 171726193 112 + 0.228 0.344 0.801
ENSG00000077380 E034 201.8203479 0.0005361817 0.8293953395 0.892880654 2 171726194 171726293 100 + 2.250 2.256 0.022
ENSG00000077380 E035 0.2966881 0.0270956355 1.0000000000   2 171726558 171726790 233 + 0.129 0.000 -9.759
ENSG00000077380 E036 179.4460208 0.0004762659 0.1719450642 0.290734515 2 171726791 171726916 126 + 2.188 2.231 0.141
ENSG00000077380 E037 195.9512819 0.0010904521 0.1906793486 0.314605481 2 171727821 171727967 147 + 2.226 2.265 0.132
ENSG00000077380 E038 192.4362414 0.0002068810 0.5231646590 0.656897084 2 171728305 171728418 114 + 2.225 2.243 0.063
ENSG00000077380 E039 213.2598205 0.0008663955 0.8239901104 0.889092721 2 171728717 171728850 134 + 2.275 2.268 -0.024
ENSG00000077380 E040 266.3884955 0.0002070533 0.8691596372 0.919917348 2 171729709 171729853 145 + 2.370 2.366 -0.013
ENSG00000077380 E041 235.9480442 0.0001947553 0.0233092356 0.058393144 2 171744049 171744189 141 + 2.300 2.360 0.197
ENSG00000077380 E042 240.6663259 0.0004911192 0.0162903359 0.043366195 2 171745802 171745927 126 + 2.309 2.374 0.217
ENSG00000077380 E043 105.2458107 0.0013978220 0.2645780872 0.402543628 2 171747776 171747778 3 + 1.956 2.005 0.162
ENSG00000077380 E044 261.2522176 0.0001925253 0.0164000565 0.043615379 2 171747779 171750158 2380 + 2.346 2.406 0.199