ENSG00000077235

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356183 ENSG00000077235 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF3C1 protein_coding protein_coding 101.9614 144.5376 76.62109 8.254553 1.164489 -0.9155426 23.898333 27.68135 13.728944 2.821640 0.8847799 -1.0111642 0.23750833 0.19516667 0.1789667 -0.01620000 9.091783e-01 6.797559e-31 FALSE TRUE
ENST00000561623 ENSG00000077235 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF3C1 protein_coding protein_coding 101.9614 144.5376 76.62109 8.254553 1.164489 -0.9155426 33.821860 41.18203 31.237156 2.619241 1.1904789 -0.3986402 0.34765000 0.28853333 0.4076333 0.11910000 7.198948e-02 6.797559e-31 FALSE TRUE
ENST00000567843 ENSG00000077235 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF3C1 protein_coding processed_transcript 101.9614 144.5376 76.62109 8.254553 1.164489 -0.9155426 23.837123 38.63900 17.379548 3.508512 1.2276397 -1.1522107 0.22690417 0.26623333 0.2264333 -0.03980000 2.993083e-01 6.797559e-31 FALSE FALSE
ENST00000569394 ENSG00000077235 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF3C1 protein_coding retained_intron 101.9614 144.5376 76.62109 8.254553 1.164489 -0.9155426 6.413125 9.06719 3.352088 4.552872 1.6845652 -1.4328880 0.05415000 0.05936667 0.0440000 -0.01536667 9.891516e-01 6.797559e-31 FALSE FALSE
ENST00000569653 ENSG00000077235 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF3C1 protein_coding protein_coding 101.9614 144.5376 76.62109 8.254553 1.164489 -0.9155426 6.052449 22.25175 0.000000 4.983025 0.0000000 -11.1203514 0.04209167 0.15103333 0.0000000 -0.15103333 4.072123e-28 6.797559e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000077235 E001 0.3332198 0.0296643353 7.203146e-01   16 27459555 27459613 59 - 0.151 0.099 -0.706
ENSG00000077235 E002 2.0346653 0.0077693700 7.414750e-01 8.306342e-01 16 27460456 27460612 157 - 0.425 0.483 0.294
ENSG00000077235 E003 79.7008561 0.0168710946 7.378705e-08 7.688650e-07 16 27460613 27460675 63 - 1.550 1.990 1.488
ENSG00000077235 E004 1026.7435503 0.0059196800 1.271185e-22 1.087233e-20 16 27460676 27460980 305 - 2.689 3.085 1.317
ENSG00000077235 E005 951.8294835 0.0068996198 6.602983e-14 1.925077e-12 16 27460981 27461096 116 - 2.714 3.039 1.082
ENSG00000077235 E006 1132.3945582 0.0050842429 1.627879e-20 1.106952e-18 16 27461097 27461295 199 - 2.772 3.119 1.152
ENSG00000077235 E007 1269.4553209 0.0044067103 4.707408e-20 3.005744e-18 16 27461296 27461562 267 - 2.846 3.162 1.051
ENSG00000077235 E008 13.8378832 0.0148737827 6.778435e-01 7.824483e-01 16 27461563 27462293 731 - 1.116 1.162 0.165
ENSG00000077235 E009 663.9965408 0.0042575951 3.187442e-10 5.167749e-09 16 27462294 27462409 116 - 2.636 2.862 0.751
ENSG00000077235 E010 535.7266155 0.0021196541 8.828284e-16 3.360442e-14 16 27462410 27462486 77 - 2.539 2.770 0.766
ENSG00000077235 E011 23.6880158 0.0079188904 8.164995e-01 8.838899e-01 16 27462487 27463473 987 - 1.385 1.368 -0.061
ENSG00000077235 E012 449.0340769 0.0018811115 2.474116e-15 8.888941e-14 16 27463541 27463592 52 - 2.466 2.693 0.756
ENSG00000077235 E013 82.2586928 0.0016600130 7.468250e-02 1.510304e-01 16 27463593 27464319 727 - 1.944 1.866 -0.262
ENSG00000077235 E014 203.6318272 0.0023496130 4.395661e-14 1.314514e-12 16 27464320 27464394 75 - 2.082 2.364 0.944
ENSG00000077235 E015 339.8505981 0.0033150284 4.607757e-10 7.261069e-09 16 27464395 27464409 15 - 2.347 2.573 0.752
ENSG00000077235 E016 1235.5523238 0.0013005422 2.954523e-32 5.800264e-30 16 27464410 27464836 427 - 2.888 3.136 0.823
ENSG00000077235 E017 1123.9242146 0.0027630707 7.673271e-13 1.919554e-11 16 27465260 27465540 281 - 2.882 3.084 0.673
ENSG00000077235 E018 6.8484146 0.0031029546 9.790538e-03 2.824837e-02 16 27465541 27466327 787 - 0.592 0.950 1.443
ENSG00000077235 E019 696.2218529 0.0025099137 4.387004e-11 8.219808e-10 16 27469291 27469401 111 - 2.683 2.874 0.636
ENSG00000077235 E020 936.9177116 0.0021072470 4.137607e-04 1.827301e-03 16 27469402 27469550 149 - 2.884 2.976 0.305
ENSG00000077235 E021 439.9224288 0.0024410573 2.091017e-01 3.374565e-01 16 27470108 27470108 1 - 2.593 2.632 0.132
ENSG00000077235 E022 808.8205810 0.0008107934 7.210771e-04 2.974219e-03 16 27470109 27470222 114 - 2.839 2.904 0.219
ENSG00000077235 E023 975.1925670 0.0008752694 2.044552e-02 5.242748e-02 16 27470223 27470395 173 - 2.934 2.979 0.148
ENSG00000077235 E024 0.4782907 0.0221770087 1.899342e-01 3.136821e-01 16 27470683 27470719 37 - 0.001 0.246 9.081
ENSG00000077235 E025 1.0413763 0.4117301553 6.742695e-01 7.797719e-01 16 27471565 27471747 183 - 0.352 0.292 -0.384
ENSG00000077235 E026 493.0119117 0.0005902950 2.613723e-01 3.990152e-01 16 27471748 27471790 43 - 2.653 2.676 0.079
ENSG00000077235 E027 755.7682067 0.0001115261 2.631744e-01 4.010425e-01 16 27471791 27471920 130 - 2.842 2.858 0.055
ENSG00000077235 E028 658.6312134 0.0001482904 3.940252e-01 5.379219e-01 16 27476451 27476544 94 - 2.801 2.788 -0.041
ENSG00000077235 E029 590.4651663 0.0001138485 2.084515e-03 7.485785e-03 16 27478469 27478531 63 - 2.776 2.728 -0.159
ENSG00000077235 E030 2.5517821 0.0118331422 1.503079e-01 2.621005e-01 16 27478532 27478594 63 - 0.676 0.444 -1.070
ENSG00000077235 E031 3.7108664 0.0159094937 6.674480e-01 7.746778e-01 16 27480716 27481078 363 - 0.592 0.661 0.302
ENSG00000077235 E032 514.0704602 0.0001321146 9.346669e-03 2.714879e-02 16 27481079 27481114 36 - 2.713 2.670 -0.144
ENSG00000077235 E033 591.2999062 0.0007965706 3.414836e-02 8.004782e-02 16 27481115 27481191 77 - 2.773 2.732 -0.138
ENSG00000077235 E034 1.3371074 0.0314410289 4.145276e-02 9.372249e-02 16 27482511 27482585 75 - 0.543 0.180 -2.285
ENSG00000077235 E035 516.0742244 0.0021689024 2.389972e-01 3.729566e-01 16 27483044 27483125 82 - 2.707 2.677 -0.098
ENSG00000077235 E036 1.7360052 0.0080193112 2.119667e-02 5.400746e-02 16 27483138 27483432 295 - 0.636 0.247 -2.121
ENSG00000077235 E037 588.9742625 0.0027906884 6.112487e-01 7.303803e-01 16 27484211 27484353 143 - 2.752 2.741 -0.037
ENSG00000077235 E038 484.0652426 0.0022000100 6.693372e-01 7.761621e-01 16 27485997 27486139 143 - 2.649 2.665 0.052
ENSG00000077235 E039 270.1882926 0.0019777354 6.646278e-01 7.724336e-01 16 27486140 27486154 15 - 2.396 2.412 0.054
ENSG00000077235 E040 9.0204915 0.0020246093 1.208514e-01 2.211601e-01 16 27488219 27488226 8 - 0.859 1.039 0.672
ENSG00000077235 E041 758.4854737 0.0020620241 5.367461e-04 2.297290e-03 16 27488227 27488415 189 - 2.910 2.825 -0.283
ENSG00000077235 E042 513.3599861 0.0026613488 3.758420e-06 2.752838e-05 16 27488554 27488635 82 - 2.770 2.636 -0.447
ENSG00000077235 E043 542.6372004 0.0022703468 1.845996e-08 2.167184e-07 16 27489043 27489178 136 - 2.805 2.652 -0.511
ENSG00000077235 E044 469.6499456 0.0027515186 5.795277e-05 3.214081e-04 16 27489602 27489743 142 - 2.722 2.603 -0.399
ENSG00000077235 E045 495.8905288 0.0039136431 5.586645e-04 2.379918e-03 16 27492338 27492515 178 - 2.743 2.628 -0.382
ENSG00000077235 E046 353.5846621 0.0089131832 4.427093e-02 9.888342e-02 16 27492617 27492713 97 - 2.585 2.491 -0.313
ENSG00000077235 E047 398.6530525 0.0048117102 2.482330e-05 1.506938e-04 16 27493199 27493296 98 - 2.674 2.517 -0.525
ENSG00000077235 E048 425.2338057 0.0056690031 6.119886e-05 3.373764e-04 16 27494763 27494908 146 - 2.702 2.545 -0.522
ENSG00000077235 E049 530.6163256 0.0100968297 1.287425e-03 4.934624e-03 16 27495211 27495492 282 - 2.797 2.642 -0.517
ENSG00000077235 E050 492.3591591 0.0041970116 1.704893e-07 1.656428e-06 16 27497637 27497821 185 - 2.779 2.598 -0.600
ENSG00000077235 E051 422.3862199 0.0037691522 4.032584e-10 6.427943e-09 16 27498630 27498733 104 - 2.730 2.517 -0.708
ENSG00000077235 E052 426.8561568 0.0055088640 6.248796e-10 9.632349e-09 16 27501191 27501306 116 - 2.751 2.508 -0.808
ENSG00000077235 E053 279.7457452 0.0042215349 7.111679e-12 1.516873e-10 16 27501307 27501344 38 - 2.576 2.318 -0.861
ENSG00000077235 E054 485.7446368 0.0057753075 3.549601e-11 6.750264e-10 16 27502859 27502995 137 - 2.817 2.555 -0.873
ENSG00000077235 E055 527.1191357 0.0044236681 2.802507e-13 7.481000e-12 16 27505899 27506116 218 - 2.850 2.592 -0.860
ENSG00000077235 E056 583.3033562 0.0042059632 8.885982e-14 2.546396e-12 16 27506847 27507156 310 - 2.893 2.638 -0.849
ENSG00000077235 E057 413.4144581 0.0065645475 2.090030e-13 5.675888e-12 16 27508540 27508655 116 - 2.774 2.460 -1.043
ENSG00000077235 E058 452.1396574 0.0089700858 1.390098e-10 2.395615e-09 16 27511749 27511901 153 - 2.811 2.501 -1.031
ENSG00000077235 E059 392.8036766 0.0076508786 3.411939e-10 5.496909e-09 16 27528598 27528721 124 - 2.738 2.451 -0.957
ENSG00000077235 E060 379.8172839 0.0085378593 2.091223e-10 3.491152e-09 16 27533291 27533387 97 - 2.732 2.428 -1.013
ENSG00000077235 E061 410.3504364 0.0080780490 2.872020e-12 6.541970e-11 16 27537784 27537927 144 - 2.776 2.450 -1.086
ENSG00000077235 E062 371.6920175 0.0083705623 1.966566e-10 3.298450e-09 16 27538180 27538356 177 - 2.722 2.419 -1.007
ENSG00000077235 E063 336.5157699 0.0073852953 1.069453e-12 2.609875e-11 16 27545314 27545523 210 - 2.689 2.365 -1.082
ENSG00000077235 E064 257.0531877 0.0113835771 4.784527e-09 6.266258e-08 16 27549670 27549949 280 - 2.573 2.248 -1.084