ENSG00000077147

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371142 ENSG00000077147 HEK293_OSMI2_2hA HEK293_TMG_2hB TM9SF3 protein_coding protein_coding 89.37965 27.90535 137.1167 0.9092015 3.738078 2.296378 13.11368 5.097249 24.40294 0.2428284 0.9079311 2.257028 0.1539583 0.1825000 0.1778667 -0.004633333 8.984846e-01 1.682474e-115 FALSE TRUE
MSTRG.4426.3 ENSG00000077147 HEK293_OSMI2_2hA HEK293_TMG_2hB TM9SF3 protein_coding   89.37965 27.90535 137.1167 0.9092015 3.738078 2.296378 18.89145 12.334767 29.68170 1.3894834 1.5563072 1.266160 0.2972000 0.4433000 0.2168333 -0.226466667 1.729689e-03 1.682474e-115 FALSE TRUE
MSTRG.4426.4 ENSG00000077147 HEK293_OSMI2_2hA HEK293_TMG_2hB TM9SF3 protein_coding   89.37965 27.90535 137.1167 0.9092015 3.738078 2.296378 21.14852 10.328932 21.89464 1.6076757 3.2992261 1.083150 0.2648583 0.3688333 0.1589000 -0.209933333 4.878863e-03 1.682474e-115 FALSE TRUE
MSTRG.4426.5 ENSG00000077147 HEK293_OSMI2_2hA HEK293_TMG_2hB TM9SF3 protein_coding   89.37965 27.90535 137.1167 0.9092015 3.738078 2.296378 35.95667 0.000000 60.78096 0.0000000 0.5606019 12.569641 0.2805500 0.0000000 0.4437667 0.443766667 1.682474e-115 1.682474e-115 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000077147 E001 1.4078924 0.1945143323 7.343952e-03 2.211274e-02 10 96518110 96518120 11 - 0.115 0.757 3.963
ENSG00000077147 E002 751.0442620 0.0008559641 5.501726e-02 1.180302e-01 10 96518121 96520384 2264 - 2.762 2.867 0.348
ENSG00000077147 E003 114.1319515 0.0005029667 6.793793e-04 2.823623e-03 10 96520385 96520672 288 - 1.986 1.904 -0.278
ENSG00000077147 E004 2067.0416372 0.0035753954 2.694098e-29 4.256787e-27 10 96520673 96521893 1221 - 3.125 3.477 1.170
ENSG00000077147 E005 1250.8412905 0.0004499275 3.446755e-07 3.149763e-06 10 96521894 96522276 383 - 2.974 3.115 0.467
ENSG00000077147 E006 476.8576420 0.0006140446 4.548015e-01 5.953948e-01 10 96522277 96522330 54 - 2.570 2.653 0.273
ENSG00000077147 E007 469.5330778 0.0002247783 9.364907e-01 9.640693e-01 10 96527213 96527289 77 - 2.567 2.635 0.225
ENSG00000077147 E008 475.1223969 0.0001351146 3.175621e-02 7.537958e-02 10 96527413 96527496 84 - 2.583 2.606 0.075
ENSG00000077147 E009 10.7839276 0.0087069518 1.168997e-01 2.155441e-01 10 96527497 96527545 49 - 1.016 0.863 -0.576
ENSG00000077147 E010 539.6518467 0.0010805117 2.027974e-02 5.207117e-02 10 96528031 96528177 147 - 2.641 2.650 0.031
ENSG00000077147 E011 419.0635790 0.0012517506 5.519722e-02 1.183287e-01 10 96530540 96530608 69 - 2.530 2.542 0.042
ENSG00000077147 E012 598.5914529 0.0011404162 1.755678e-01 2.954256e-01 10 96533051 96533190 140 - 2.679 2.712 0.107
ENSG00000077147 E013 2.6121218 0.0082785057 3.567073e-02 8.294139e-02 10 96543601 96544075 475 - 0.373 0.771 1.848
ENSG00000077147 E014 612.9016443 0.0002349613 3.841021e-03 1.269553e-02 10 96544076 96544206 131 - 2.694 2.706 0.038
ENSG00000077147 E015 495.8412811 0.0004746842 1.534715e-03 5.748946e-03 10 96547895 96547989 95 - 2.606 2.602 -0.015
ENSG00000077147 E016 372.4982137 0.0001559764 5.026680e-03 1.600540e-02 10 96551245 96551310 66 - 2.483 2.484 0.004
ENSG00000077147 E017 501.5816546 0.0001525276 3.570145e-05 2.082561e-04 10 96551311 96551411 101 - 2.614 2.597 -0.059
ENSG00000077147 E018 624.6948255 0.0017970156 1.154390e-04 5.929285e-04 10 96552928 96553023 96 - 2.713 2.673 -0.132
ENSG00000077147 E019 411.7377531 0.0011751545 1.072352e-06 8.843161e-06 10 96553024 96553059 36 - 2.539 2.468 -0.236
ENSG00000077147 E020 477.6673209 0.0001707017 5.249203e-08 5.634253e-07 10 96559659 96559736 78 - 2.599 2.550 -0.163
ENSG00000077147 E021 652.0913251 0.0001309216 7.276542e-23 6.367294e-21 10 96561978 96562138 161 - 2.745 2.629 -0.389
ENSG00000077147 E022 485.7929946 0.0001418835 1.151221e-20 7.974239e-19 10 96565304 96565426 123 - 2.621 2.485 -0.452
ENSG00000077147 E023 0.1515154 0.0428034587 1.000000e+00   10 96576345 96576633 289 - 0.061 0.000 -7.692
ENSG00000077147 E024 521.3686486 0.0001337867 2.770780e-41 1.039437e-38 10 96576634 96576829 196 - 2.666 2.438 -0.759
ENSG00000077147 E025 0.2214452 0.0414148724 1.068198e-01   10 96577479 96577542 64 - 0.000 0.231 11.840
ENSG00000077147 E026 3.4238490 0.0543811317 2.062222e-01 3.339846e-01 10 96586155 96586733 579 - 0.494 0.775 1.224
ENSG00000077147 E027 211.5169073 0.0001755960 2.038787e-31 3.757339e-29 10 96586734 96586836 103 - 2.290 1.933 -1.197
ENSG00000077147 E028 121.2014743 0.0021822895 2.112670e-24 2.177578e-22 10 96586837 96586974 138 - 2.065 1.539 -1.777
ENSG00000077147 E029 25.0346299 0.0221594446 5.503833e-08 5.878626e-07 10 96586975 96587012 38 - 1.410 0.653 -2.819
ENSG00000077147 E030 3.4731588 0.0045364653 1.370482e-01 2.439800e-01 10 96587376 96587452 77 - 0.621 0.380 -1.182