ENSG00000077097

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264331 ENSG00000077097 HEK293_OSMI2_2hA HEK293_TMG_2hB TOP2B protein_coding protein_coding 69.89524 34.93298 93.42604 1.398116 5.88156 1.418976 8.884733 2.193703 13.56985 0.9008410 1.972258 2.6234660 0.1117083 0.06306667 0.1491333 0.08606667 2.071713e-01 3.701188e-07 FALSE TRUE
ENST00000413971 ENSG00000077097 HEK293_OSMI2_2hA HEK293_TMG_2hB TOP2B protein_coding nonsense_mediated_decay 69.89524 34.93298 93.42604 1.398116 5.88156 1.418976 31.989758 25.349745 31.03505 1.2997184 4.201022 0.2918228 0.5229708 0.72720000 0.3292667 -0.39793333 3.701188e-07 3.701188e-07 FALSE TRUE
ENST00000424225 ENSG00000077097 HEK293_OSMI2_2hA HEK293_TMG_2hB TOP2B protein_coding protein_coding 69.89524 34.93298 93.42604 1.398116 5.88156 1.418976 17.798177 4.936585 19.22828 0.6386557 3.723620 1.9594749 0.2135500 0.14133333 0.2022667 0.06093333 3.756314e-01 3.701188e-07 FALSE TRUE
ENST00000435706 ENSG00000077097 HEK293_OSMI2_2hA HEK293_TMG_2hB TOP2B protein_coding protein_coding 69.89524 34.93298 93.42604 1.398116 5.88156 1.418976 6.291286 2.142700 20.07197 0.9630735 1.342958 3.2216817 0.0986250 0.05943333 0.2183000 0.15886667 5.454374e-03 3.701188e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000077097 E001 1.0287926 0.3241205848 7.158482e-01 8.116642e-01 3 25597954 25597983 30 - 0.265 0.345 0.531
ENSG00000077097 E002 7.2874520 0.0791266605 4.530880e-04 1.978936e-03 3 25597984 25597985 2 - 0.625 1.231 2.317
ENSG00000077097 E003 10.7431738 0.0586762325 9.962214e-06 6.623308e-05 3 25597986 25597989 4 - 0.732 1.415 2.509
ENSG00000077097 E004 129.9857816 0.0285799698 8.709572e-13 2.160537e-11 3 25597990 25598068 79 - 1.774 2.445 2.249
ENSG00000077097 E005 860.6681305 0.0189761107 2.540929e-10 4.178572e-09 3 25598069 25598477 409 - 2.717 3.153 1.449
ENSG00000077097 E006 532.1093864 0.0034457251 4.293986e-12 9.494431e-11 3 25599435 25599529 95 - 2.588 2.831 0.807
ENSG00000077097 E007 522.6894211 0.0011266812 2.057045e-16 8.503186e-15 3 25601100 25601225 126 - 2.593 2.798 0.684
ENSG00000077097 E008 351.2884951 0.0007914626 4.106198e-20 2.645042e-18 3 25604760 25604870 111 - 2.409 2.647 0.794
ENSG00000077097 E009 268.2681536 0.0002261979 1.072005e-13 3.032525e-12 3 25606043 25606122 80 - 2.307 2.504 0.658
ENSG00000077097 E010 515.4583079 0.0001174089 4.644903e-20 2.967834e-18 3 25607171 25607375 205 - 2.595 2.772 0.589
ENSG00000077097 E011 438.5872355 0.0003335655 2.882868e-08 3.256324e-07 3 25609183 25609344 162 - 2.541 2.670 0.432
ENSG00000077097 E012 446.9735636 0.0003242138 8.452154e-07 7.132768e-06 3 25609568 25609712 145 - 2.552 2.669 0.388
ENSG00000077097 E013 290.8671336 0.0021738355 5.456656e-04 2.330674e-03 3 25612515 25612570 56 - 2.364 2.492 0.428
ENSG00000077097 E014 414.0815039 0.0001510876 4.270446e-10 6.771202e-09 3 25612571 25612709 139 - 2.513 2.653 0.467
ENSG00000077097 E015 297.1341687 0.0001602225 1.130001e-04 5.816473e-04 3 25615205 25615288 84 - 2.378 2.485 0.357
ENSG00000077097 E016 177.4917999 0.0002079040 1.232965e-04 6.289384e-04 3 25615431 25615472 42 - 2.147 2.279 0.441
ENSG00000077097 E017 303.2711694 0.0032606465 6.244781e-02 1.307648e-01 3 25615473 25615586 114 - 2.391 2.480 0.296
ENSG00000077097 E018 0.8772652 0.0803750019 1.985835e-01 3.244117e-01 3 25615781 25615941 161 - 0.304 0.000 -9.968
ENSG00000077097 E019 287.5314777 0.0068579781 9.214528e-01 9.544206e-01 3 25618418 25618509 92 - 2.385 2.416 0.105
ENSG00000077097 E020 393.4340254 0.0026937880 9.920105e-01 9.991091e-01 3 25618654 25618849 196 - 2.523 2.543 0.068
ENSG00000077097 E021 341.2385309 0.0055919036 9.585188e-01 9.780070e-01 3 25619862 25620062 201 - 2.460 2.487 0.088
ENSG00000077097 E022 344.7207408 0.0060048469 1.526629e-01 2.652939e-01 3 25620682 25620816 135 - 2.481 2.443 -0.127
ENSG00000077097 E023 466.2876068 0.0028868790 1.886161e-03 6.871310e-03 3 25623515 25623746 232 - 2.621 2.540 -0.267
ENSG00000077097 E024 222.2115833 0.0003076623 2.264950e-02 5.702318e-02 3 25624297 25624351 55 - 2.293 2.241 -0.173
ENSG00000077097 E025 267.6456614 0.0001511723 1.966851e-05 1.222286e-04 3 25624352 25624445 94 - 2.385 2.286 -0.332
ENSG00000077097 E026 291.8276063 0.0001458484 2.564899e-07 2.406353e-06 3 25624682 25624803 122 - 2.426 2.308 -0.396
ENSG00000077097 E027 3.8448493 0.0053887206 9.514570e-03 2.757307e-02 3 25624804 25625038 235 - 0.718 0.211 -2.751
ENSG00000077097 E028 258.8552900 0.0001907595 1.053054e-09 1.555054e-08 3 25626560 25626674 115 - 2.382 2.225 -0.524
ENSG00000077097 E029 235.8515606 0.0002357812 1.099868e-14 3.595010e-13 3 25626772 25626864 93 - 2.352 2.131 -0.739
ENSG00000077097 E030 1.5384948 0.0924441180 3.878210e-01 5.319628e-01 3 25627057 25627186 130 - 0.401 0.213 -1.264
ENSG00000077097 E031 259.2721308 0.0004157793 8.599954e-14 2.467791e-12 3 25627187 25627296 110 - 2.390 2.183 -0.693
ENSG00000077097 E032 263.8795672 0.0001943813 3.576357e-12 8.011470e-11 3 25628847 25628952 106 - 2.394 2.212 -0.607
ENSG00000077097 E033 239.6015430 0.0005252422 3.182283e-10 5.160268e-09 3 25629035 25629145 111 - 2.352 2.172 -0.601
ENSG00000077097 E034 218.1544795 0.0002049102 1.246529e-07 1.243359e-06 3 25630029 25630154 126 - 2.305 2.159 -0.489
ENSG00000077097 E035 0.1482932 0.0422300390 1.242588e-01   3 25630155 25630155 1 - 0.000 0.211 10.892
ENSG00000077097 E036 240.1316507 0.0004692220 4.707722e-11 8.779916e-10 3 25630312 25630469 158 - 2.354 2.166 -0.627
ENSG00000077097 E037 235.4120102 0.0035759800 6.385176e-09 8.171671e-08 3 25630801 25630939 139 - 2.354 2.123 -0.770
ENSG00000077097 E038 189.2931941 0.0082132617 2.905128e-04 1.341248e-03 3 25632446 25632583 138 - 2.252 2.070 -0.609
ENSG00000077097 E039 197.9387585 0.0003858977 1.381864e-14 4.461314e-13 3 25632693 25632794 102 - 2.281 2.032 -0.832
ENSG00000077097 E040 270.5239903 0.0109626181 4.081366e-09 5.402099e-08 3 25633841 25634014 174 - 2.428 2.098 -1.103
ENSG00000077097 E041 341.3025979 0.0248328027 5.048896e-06 3.590189e-05 3 25635936 25636148 213 - 2.531 2.190 -1.139
ENSG00000077097 E042 229.0902694 0.0340598210 7.808394e-05 4.189162e-04 3 25637215 25637312 98 - 2.359 2.013 -1.158
ENSG00000077097 E043 188.3673529 0.0170233826 2.133216e-06 1.648977e-05 3 25638165 25638249 85 - 2.271 1.946 -1.089
ENSG00000077097 E044 161.4152657 0.0143416514 6.983905e-06 4.811724e-05 3 25638250 25638310 61 - 2.201 1.906 -0.990
ENSG00000077097 E045 191.7091567 0.0163732130 2.764823e-08 3.134950e-07 3 25642322 25642385 64 - 2.287 1.900 -1.299
ENSG00000077097 E046 230.6580727 0.0111387704 2.293560e-14 7.153575e-13 3 25643694 25643784 91 - 2.376 1.908 -1.565
ENSG00000077097 E047 219.9350398 0.0014001217 2.283564e-45 1.086971e-42 3 25645300 25645455 156 - 2.366 1.778 -1.971
ENSG00000077097 E048 9.0395400 0.1185424910 4.201662e-03 1.370770e-02 3 25645456 25645470 15 - 1.038 0.353 -2.981
ENSG00000077097 E049 90.4556816 0.0148824209 5.113832e-14 1.516119e-12 3 25664229 25664340 112 - 1.988 1.328 -2.248
ENSG00000077097 E050 165.2723983 0.0792948373 6.367367e-05 3.494130e-04 3 25664341 25664829 489 - 2.239 1.704 -1.796
ENSG00000077097 E051 62.8396510 0.0623575333 2.603758e-03 9.076048e-03 3 25664830 25664872 43 - 1.807 1.428 -1.289
ENSG00000077097 E052 49.3550056 0.0490381307 5.000355e-04 2.160240e-03 3 25664873 25664875 3 - 1.710 1.278 -1.484
ENSG00000077097 E053 47.5362688 0.0467701804 4.929675e-04 2.133246e-03 3 25664876 25665009 134 - 1.694 1.263 -1.483