ENSG00000077063

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000160373 ENSG00000077063 HEK293_OSMI2_2hA HEK293_TMG_2hB CTTNBP2 protein_coding protein_coding 1.221659 0.7642564 1.610806 0.1593716 0.1889262 1.065828 0.52601223 0.4479162 0.6825662 0.02289934 0.1231417 0.5968685 0.50732083 0.6587667 0.4381333 -0.2206333 0.641438518 0.004725296 FALSE TRUE
ENST00000416239 ENSG00000077063 HEK293_OSMI2_2hA HEK293_TMG_2hB CTTNBP2 protein_coding protein_coding 1.221659 0.7642564 1.610806 0.1593716 0.1889262 1.065828 0.16875439 0.1642570 0.4223976 0.16425704 0.2124832 1.3111415 0.12429167 0.1576333 0.2361333 0.0785000 0.769111176 0.004725296 FALSE FALSE
ENST00000441556 ENSG00000077063 HEK293_OSMI2_2hA HEK293_TMG_2hB CTTNBP2 protein_coding nonsense_mediated_decay 1.221659 0.7642564 1.610806 0.1593716 0.1889262 1.065828 0.32989599 0.0000000 0.4515441 0.00000000 0.1617827 5.5283965 0.22319583 0.0000000 0.2824667 0.2824667 0.004725296 0.004725296 FALSE TRUE
ENST00000445366 ENSG00000077063 HEK293_OSMI2_2hA HEK293_TMG_2hB CTTNBP2 protein_coding nonsense_mediated_decay 1.221659 0.7642564 1.610806 0.1593716 0.1889262 1.065828 0.07316772 0.1060675 0.0000000 0.10606754 0.0000000 -3.5368927 0.05184583 0.1394333 0.0000000 -0.1394333 0.659153412 0.004725296 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000077063 E001 1.4047574 0.0627472403 2.703530e-03 9.384630e-03 7 117710651 117710740 90 - 0.088 0.634 3.884
ENSG00000077063 E002 2.1077156 0.0084003989 3.152057e-04 1.441724e-03 7 117710741 117710862 122 - 0.161 0.758 3.400
ENSG00000077063 E003 19.6019106 0.0023313802 3.795185e-06 2.776224e-05 7 117710863 117711627 765 - 1.125 1.482 1.252
ENSG00000077063 E004 10.1920468 0.0122835083 1.411104e-01 2.495654e-01 7 117711628 117711782 155 - 0.957 1.125 0.614
ENSG00000077063 E005 8.0395558 0.0942399619 5.354258e-01 6.672567e-01 7 117718018 117718119 102 - 0.901 1.000 0.370
ENSG00000077063 E006 7.4649678 0.0024399464 6.182865e-02 1.296991e-01 7 117719504 117719636 133 - 0.820 1.039 0.826
ENSG00000077063 E007 5.0082119 0.0035263957 9.907590e-01 9.983900e-01 7 117721067 117721130 64 - 0.756 0.758 0.008
ENSG00000077063 E008 8.1500212 0.0020959949 6.591900e-01 7.680640e-01 7 117724547 117724732 186 - 0.924 0.978 0.203
ENSG00000077063 E009 8.9521848 0.0020897280 8.947270e-01 9.367154e-01 7 117725052 117725257 206 - 0.988 0.978 -0.038
ENSG00000077063 E010 8.2846996 0.0022206473 8.042948e-01 8.755005e-01 7 117728089 117728267 179 - 0.957 0.933 -0.091
ENSG00000077063 E011 5.9449260 0.0426088112 5.402538e-01 6.714170e-01 7 117734913 117735100 188 - 0.861 0.759 -0.400
ENSG00000077063 E012 2.3261592 0.0065642745 6.313369e-01 7.463503e-01 7 117735269 117735330 62 - 0.540 0.461 -0.382
ENSG00000077063 E013 3.1710704 0.0052245274 3.897017e-01 5.337697e-01 7 117735331 117735421 91 - 0.661 0.527 -0.601
ENSG00000077063 E014 4.4329375 0.0035559017 6.620043e-02 1.370488e-01 7 117745831 117745930 100 - 0.805 0.527 -1.185
ENSG00000077063 E015 5.0135265 0.0036155063 1.554571e-01 2.690020e-01 7 117746013 117746099 87 - 0.834 0.634 -0.816
ENSG00000077063 E016 0.0000000       7 117755372 117755379 8 -      
ENSG00000077063 E017 1.7724366 0.2758690145 8.717400e-01 9.215055e-01 7 117755380 117755574 195 - 0.409 0.510 0.515
ENSG00000077063 E018 7.7952604 0.0501398715 7.341799e-01 8.252006e-01 7 117756555 117756634 80 - 0.946 0.906 -0.153
ENSG00000077063 E019 9.0171937 0.0024952946 3.279592e-01 4.714287e-01 7 117757875 117757970 96 - 0.946 1.057 0.407
ENSG00000077063 E020 0.0000000       7 117757971 117758112 142 -      
ENSG00000077063 E021 0.0000000       7 117760268 117760434 167 -      
ENSG00000077063 E022 12.5861031 0.0015167634 6.202192e-01 7.374752e-01 7 117760435 117760710 276 - 1.102 1.153 0.184
ENSG00000077063 E023 8.5155234 0.0021469323 5.953873e-01 7.174939e-01 7 117767059 117767176 118 - 0.988 0.933 -0.208
ENSG00000077063 E024 0.0000000       7 117767177 117767191 15 -      
ENSG00000077063 E025 10.3745616 0.0218864197 8.086275e-01 8.784469e-01 7 117777511 117777765 255 - 1.026 1.059 0.118
ENSG00000077063 E026 7.2798790 0.0102437636 4.564869e-01 5.969041e-01 7 117780441 117780591 151 - 0.862 0.957 0.362
ENSG00000077063 E027 3.7538204 0.0047969236 4.990252e-01 6.353779e-01 7 117782862 117782961 100 - 0.617 0.721 0.441
ENSG00000077063 E028 7.7972215 0.0022533586 9.703027e-01 9.854139e-01 7 117784251 117784454 204 - 0.924 0.933 0.033
ENSG00000077063 E029 0.4502799 0.0318093713 2.722089e-01 4.110637e-01 7 117786386 117786425 40 - 0.223 0.000 -11.113
ENSG00000077063 E030 5.8504926 0.0076193801 6.436768e-01 7.561658e-01 7 117791128 117791290 163 - 0.789 0.855 0.256
ENSG00000077063 E031 32.2667396 0.0007602624 5.028330e-06 3.577579e-05 7 117791291 117792585 1295 - 1.592 1.299 -1.010
ENSG00000077063 E032 3.3300494 0.0047086628 9.690277e-03 2.799960e-02 7 117792586 117792595 10 - 0.739 0.289 -2.244
ENSG00000077063 E033 4.1458143 0.0038871030 3.743624e-02 8.628746e-02 7 117792596 117792661 66 - 0.789 0.461 -1.446
ENSG00000077063 E034 5.3519311 0.0032200970 1.031132e-01 1.952154e-01 7 117792662 117792781 120 - 0.862 0.634 -0.923
ENSG00000077063 E035 0.0000000       7 117793413 117793605 193 -      
ENSG00000077063 E036 2.5808026 0.0097630322 4.296445e-01 5.723407e-01 7 117810765 117810766 2 - 0.592 0.461 -0.624
ENSG00000077063 E037 4.7040523 0.0286793346 2.791325e-01 4.188413e-01 7 117810767 117810989 223 - 0.804 0.633 -0.703
ENSG00000077063 E038 2.3344765 0.0068006898 5.439632e-01 6.744911e-01 7 117861209 117861316 108 - 0.479 0.584 0.491
ENSG00000077063 E039 0.0000000       7 117871590 117871638 49 -      
ENSG00000077063 E040 0.1482932 0.0413177441 2.350655e-01   7 117872104 117872220 117 - 0.000 0.168 10.523
ENSG00000077063 E041 1.2264046 0.1154732465 6.970790e-01 7.972972e-01 7 117873335 117873441 107 - 0.370 0.288 -0.517
ENSG00000077063 E042 0.0000000       7 117874001 117874139 139 -