ENSG00000076984

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397979 ENSG00000076984 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP2K7 protein_coding protein_coding 32.85327 48.46771 23.61423 3.174202 0.8014843 -1.037054 21.5656517 34.395839 12.670168 1.7281631 0.72601841 -1.4400796 0.63405417 0.71120000 0.53696667 -0.174233333 2.247359e-04 4.927676e-08 FALSE TRUE
ENST00000397981 ENSG00000076984 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP2K7 protein_coding protein_coding 32.85327 48.46771 23.61423 3.174202 0.8014843 -1.037054 2.2131836 3.378554 1.459571 0.4683389 0.20531332 -1.2052742 0.06598750 0.06903333 0.06210000 -0.006933333 8.365765e-01 4.927676e-08 FALSE TRUE
ENST00000397983 ENSG00000076984 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP2K7 protein_coding protein_coding 32.85327 48.46771 23.61423 3.174202 0.8014843 -1.037054 5.3055457 8.594028 5.361716 0.9058644 0.76208622 -0.6796293 0.16520000 0.17633333 0.22790000 0.051566667 5.385047e-01 4.927676e-08 FALSE TRUE
ENST00000475022 ENSG00000076984 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP2K7 protein_coding retained_intron 32.85327 48.46771 23.61423 3.174202 0.8014843 -1.037054 1.7219409 1.178655 1.675415 0.1636104 0.07406844 0.5037744 0.06125417 0.02420000 0.07090000 0.046700000 4.927676e-08 4.927676e-08   FALSE
ENST00000498118 ENSG00000076984 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP2K7 protein_coding retained_intron 32.85327 48.46771 23.61423 3.174202 0.8014843 -1.037054 0.8315999 0.000000 1.264989 0.0000000 0.75464513 6.9943415 0.03099583 0.00000000 0.05153333 0.051533333 1.231921e-01 4.927676e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000076984 E001 10.0014849 0.0024884842 7.392801e-01 8.289695e-01 19 7903843 7903876 34 + 0.983 0.984 0.001
ENSG00000076984 E002 9.3789770 0.0021468512 6.224088e-01 7.392185e-01 19 7903877 7903879 3 + 0.887 0.984 0.363
ENSG00000076984 E003 10.1820565 0.0046914137 9.732957e-01 9.873200e-01 19 7903880 7903884 5 + 0.961 1.004 0.158
ENSG00000076984 E004 39.9178702 0.0045214364 1.656634e-01 2.825675e-01 19 7903885 7903906 22 + 1.590 1.540 -0.170
ENSG00000076984 E005 120.1829374 0.0010829981 7.750256e-02 1.554523e-01 19 7903907 7904068 162 + 2.046 2.022 -0.080
ENSG00000076984 E006 12.2176043 0.0015098227 5.163817e-07 4.555388e-06 19 7904451 7904548 98 + 1.335 0.895 -1.588
ENSG00000076984 E007 27.7743336 0.0007478815 1.352280e-03 5.150520e-03 19 7905808 7905855 48 + 1.526 1.347 -0.618
ENSG00000076984 E008 48.6584354 0.0046258846 1.426952e-14 4.598262e-13 19 7905856 7907066 1211 + 1.904 1.492 -1.396
ENSG00000076984 E009 146.8398585 0.0012898141 2.529117e-01 3.893528e-01 19 7909755 7909896 142 + 2.114 2.116 0.009
ENSG00000076984 E010 86.1517455 0.0048066864 4.747752e-01 6.135845e-01 19 7910063 7910075 13 + 1.879 1.887 0.026
ENSG00000076984 E011 148.1992710 0.0061605094 3.484067e-01 4.926412e-01 19 7910076 7910129 54 + 2.118 2.122 0.011
ENSG00000076984 E012 0.9869609 0.1274596766 3.726497e-01 5.170898e-01 19 7910130 7910213 84 + 0.386 0.221 -1.109
ENSG00000076984 E013 1.5114369 0.0142039144 1.115866e-01 2.078843e-01 19 7910214 7910259 46 + 0.531 0.275 -1.437
ENSG00000076984 E014 257.7406866 0.0097733181 1.835793e-01 3.057016e-01 19 7910260 7910373 114 + 2.378 2.357 -0.071
ENSG00000076984 E015 6.7879572 0.0023679257 6.090954e-03 1.885047e-02 19 7910374 7910452 79 + 1.044 0.751 -1.117
ENSG00000076984 E016 349.8224759 0.0047223036 4.967400e-02 1.085811e-01 19 7910453 7910572 120 + 2.513 2.487 -0.088
ENSG00000076984 E017 1.9843920 0.2698564882 8.273885e-02 1.638388e-01 19 7910573 7910695 123 + 0.683 0.282 -2.064
ENSG00000076984 E018 353.7819283 0.0007424764 2.347804e-02 5.873913e-02 19 7910696 7910803 108 + 2.503 2.494 -0.031
ENSG00000076984 E019 366.6088198 0.0004045774 9.681358e-03 2.797725e-02 19 7910980 7911098 119 + 2.521 2.509 -0.042
ENSG00000076984 E020 287.3371285 0.0001889071 1.516087e-01 2.638515e-01 19 7911099 7911159 61 + 2.402 2.411 0.031
ENSG00000076984 E021 318.6125458 0.0027412613 8.679193e-01 9.190616e-01 19 7911250 7911330 81 + 2.427 2.465 0.129
ENSG00000076984 E022 2.6502920 0.3278204278 3.782301e-01 5.225072e-01 19 7911331 7911356 26 + 0.729 0.409 -1.478
ENSG00000076984 E023 11.4240545 0.0015368890 3.090909e-01 4.513744e-01 19 7911415 7911435 21 + 1.097 1.030 -0.242
ENSG00000076984 E024 403.6326596 0.0001948088 4.650794e-03 1.496042e-02 19 7911436 7911578 143 + 2.565 2.552 -0.042
ENSG00000076984 E025 290.3646974 0.0001586933 2.343344e-02 5.865079e-02 19 7912149 7912194 46 + 2.419 2.409 -0.031
ENSG00000076984 E026 2087.5779253 0.0030350973 7.782675e-09 9.788253e-08 19 7912297 7914478 2182 + 3.152 3.309 0.520