ENSG00000076928

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337665 ENSG00000076928 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF1 protein_coding protein_coding 30.79203 39.47704 21.09078 2.764766 1.259629 -0.9040834 15.3766763 23.6606809 8.711547 1.6979551 0.2147730 -1.4404452 0.48563333 0.599600000 0.41560000 -0.18400000 0.0000329125 5.770405e-07 FALSE TRUE
ENST00000378152 ENSG00000076928 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF1 protein_coding protein_coding 30.79203 39.47704 21.09078 2.764766 1.259629 -0.9040834 2.6405061 4.4844331 1.697913 0.6334701 0.4963677 -1.3959045 0.08301667 0.112433333 0.07966667 -0.03276667 0.5781938376 5.770405e-07 FALSE TRUE
ENST00000598444 ENSG00000076928 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF1 protein_coding retained_intron 30.79203 39.47704 21.09078 2.764766 1.259629 -0.9040834 0.9810734 0.3022724 1.288762 0.3022724 0.2978150 2.0562597 0.03460000 0.007366667 0.06003333 0.05266667 0.0644312177 5.770405e-07 FALSE FALSE
MSTRG.17212.8 ENSG00000076928 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF1 protein_coding   30.79203 39.47704 21.09078 2.764766 1.259629 -0.9040834 3.3098353 4.0703379 3.615490 0.6827594 0.1934461 -0.1705127 0.11692917 0.104466667 0.17183333 0.06736667 0.1305940469 5.770405e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000076928 E001 0.0000000       19 41883173 41883182 10 +      
ENSG00000076928 E002 0.0000000       19 41883183 41883183 1 +      
ENSG00000076928 E003 0.0000000       19 41883184 41883223 40 +      
ENSG00000076928 E004 0.0000000       19 41883224 41883224 1 +      
ENSG00000076928 E005 0.0000000       19 41883225 41883289 65 +      
ENSG00000076928 E006 3.6493425 0.0046989791 4.152686e-01 5.586623e-01 19 41884325 41884362 38 + 0.701 0.573 -0.550
ENSG00000076928 E007 4.7177727 0.0037458754 6.840486e-01 7.871076e-01 19 41884363 41884369 7 + 0.742 0.681 -0.251
ENSG00000076928 E008 53.7408110 0.0258870941 3.433105e-01 4.873453e-01 19 41884370 41884447 78 + 1.746 1.651 -0.322
ENSG00000076928 E009 101.0941556 0.0070123285 9.410710e-03 2.730843e-02 19 41884448 41884493 46 + 2.045 1.905 -0.469
ENSG00000076928 E010 114.9758642 0.0059478081 1.424208e-02 3.877667e-02 19 41888064 41888106 43 + 2.088 1.966 -0.410
ENSG00000076928 E011 143.4559698 0.0004342956 3.462189e-02 8.094021e-02 19 41888192 41888278 87 + 2.145 2.074 -0.239
ENSG00000076928 E012 155.7050990 0.0002398254 5.921031e-01 7.147187e-01 19 41888752 41888865 114 + 2.143 2.125 -0.062
ENSG00000076928 E013 22.6201939 0.0050429957 1.111303e-13 3.136200e-12 19 41888866 41890776 1911 + 1.660 1.079 -2.025
ENSG00000076928 E014 140.1976523 0.0009616326 2.670013e-01 4.052703e-01 19 41892025 41892123 99 + 2.119 2.079 -0.135
ENSG00000076928 E015 6.7706085 0.0025059157 2.560577e-09 3.519763e-08 19 41892124 41892330 207 + 1.232 0.521 -2.793
ENSG00000076928 E016 119.0644823 0.0012904381 2.454279e-02 6.093832e-02 19 41892331 41892373 43 + 2.083 1.995 -0.294
ENSG00000076928 E017 0.8157519 0.0157560316 1.656291e-01 2.825237e-01 19 41892374 41892528 155 + 0.399 0.153 -1.837
ENSG00000076928 E018 113.8190177 0.0026611137 2.382269e-01 3.720824e-01 19 41892603 41892633 31 + 2.037 1.986 -0.172
ENSG00000076928 E019 230.4216959 0.0013917615 2.583010e-01 3.955346e-01 19 41892634 41892849 216 + 2.329 2.295 -0.116
ENSG00000076928 E020 0.2944980 0.2834002098 8.914171e-02   19 41893190 41893273 84 + 0.302 0.000 -12.801
ENSG00000076928 E021 92.7179372 0.0003439768 1.065641e-01 2.004863e-01 19 41893274 41893303 30 + 1.956 1.890 -0.223
ENSG00000076928 E022 151.7497745 0.0022472227 1.290725e-02 3.569693e-02 19 41894207 41894291 85 + 2.188 2.095 -0.311
ENSG00000076928 E023 115.0493255 0.0003002345 6.280517e-03 1.934832e-02 19 41894292 41894306 15 + 2.072 1.972 -0.334
ENSG00000076928 E024 142.1480597 0.0042043216 3.507426e-02 8.179115e-02 19 41894451 41894486 36 + 2.162 2.070 -0.307
ENSG00000076928 E025 152.8505303 0.0002858628 1.947181e-02 5.035597e-02 19 41894487 41894547 61 + 2.178 2.103 -0.251
ENSG00000076928 E026 116.5537836 0.0040176882 1.940756e-01 3.189084e-01 19 41894626 41894661 36 + 2.051 1.993 -0.196
ENSG00000076928 E027 128.6616514 0.0005366417 1.167048e-01 2.152559e-01 19 41895349 41895378 30 + 2.090 2.034 -0.189
ENSG00000076928 E028 180.0613472 0.0002499835 4.839070e-01 6.219242e-01 19 41895379 41895486 108 + 2.211 2.189 -0.074
ENSG00000076928 E029 177.7688651 0.0023546873 7.030562e-01 8.018005e-01 19 41896377 41896482 106 + 2.203 2.188 -0.051
ENSG00000076928 E030 6.3923598 0.0025907045 5.570499e-06 3.922518e-05 19 41896483 41896878 396 + 1.148 0.597 -2.145
ENSG00000076928 E031 1.4768809 0.1126523861 5.287754e-02 1.142754e-01 19 41897315 41897326 12 + 0.604 0.215 -2.239
ENSG00000076928 E032 6.7140255 0.0025314539 1.114090e-05 7.323165e-05 19 41897675 41897810 136 + 1.148 0.620 -2.045
ENSG00000076928 E033 8.5898797 0.0026466407 1.884231e-08 2.207830e-07 19 41897811 41897945 135 + 1.281 0.662 -2.333
ENSG00000076928 E034 10.7995541 0.0284746461 5.418429e-05 3.026610e-04 19 41897946 41898113 168 + 1.323 0.816 -1.855
ENSG00000076928 E035 16.6780376 0.0011919257 7.606193e-15 2.549939e-13 19 41898114 41898423 310 + 1.558 0.912 -2.293
ENSG00000076928 E036 6.2710319 0.0027505909 3.845396e-04 1.714922e-03 19 41898424 41898441 18 + 1.081 0.641 -1.711
ENSG00000076928 E037 220.8372352 0.0003673112 6.865275e-02 1.411324e-01 19 41898442 41898587 146 + 2.318 2.267 -0.169
ENSG00000076928 E038 0.1482932 0.0417906645 1.000000e+00   19 41900836 41900933 98 + 0.000 0.083 9.019
ENSG00000076928 E039 207.7494323 0.0002912191 3.862223e-01 5.304113e-01 19 41901887 41902033 147 + 2.273 2.247 -0.084
ENSG00000076928 E040 156.0619470 0.0002440932 9.323196e-01 9.613613e-01 19 41902274 41902356 83 + 2.134 2.130 -0.014
ENSG00000076928 E041 218.8962471 0.0010439654 5.619408e-01 6.896601e-01 19 41902533 41902658 126 + 2.264 2.283 0.061
ENSG00000076928 E042 112.3017635 0.0013227859 6.561093e-01 7.658255e-01 19 41902784 41902797 14 + 1.975 1.993 0.061
ENSG00000076928 E043 202.7681956 0.0002048911 5.353094e-01 6.671717e-01 19 41902798 41902898 101 + 2.232 2.249 0.054
ENSG00000076928 E044 236.6592603 0.0002372475 5.087928e-02 1.107375e-01 19 41903307 41903407 101 + 2.276 2.327 0.169
ENSG00000076928 E045 3.0248338 0.0063682322 6.216265e-01 7.385718e-01 19 41903656 41903706 51 + 0.604 0.522 -0.375
ENSG00000076928 E046 209.4750380 0.0021927516 3.804215e-01 5.247081e-01 19 41903707 41903784 78 + 2.238 2.270 0.109
ENSG00000076928 E047 200.5401695 0.0027868372 3.441092e-01 4.881645e-01 19 41904035 41904110 76 + 2.215 2.253 0.126
ENSG00000076928 E048 249.6594784 0.0001871897 4.032494e-04 1.787045e-03 19 41904216 41904383 168 + 2.266 2.357 0.305
ENSG00000076928 E049 220.2355219 0.0002322214 7.848208e-04 3.205458e-03 19 41904949 41905036 88 + 2.210 2.303 0.310
ENSG00000076928 E050 231.4628436 0.0016343364 6.526472e-05 3.572025e-04 19 41905175 41905261 87 + 2.199 2.334 0.450
ENSG00000076928 E051 5.2099610 0.0228247284 3.166580e-03 1.075782e-02 19 41905513 41905589 77 + 1.002 0.575 -1.711
ENSG00000076928 E052 9.5046064 0.0739015885 6.087710e-03 1.884166e-02 19 41905590 41905759 170 + 1.258 0.805 -1.666
ENSG00000076928 E053 230.5537655 0.0001825733 9.572504e-04 3.812560e-03 19 41905760 41905799 40 + 2.232 2.321 0.295
ENSG00000076928 E054 200.7681268 0.0002208621 3.183812e-03 1.080803e-02 19 41905800 41905827 28 + 2.175 2.260 0.283
ENSG00000076928 E055 282.6163997 0.0001765339 4.171244e-04 1.840054e-03 19 41905939 41906025 87 + 2.322 2.408 0.285
ENSG00000076928 E056 15.6001598 0.0199052058 3.470505e-06 2.562863e-05 19 41906026 41906335 310 + 1.464 0.968 -1.760
ENSG00000076928 E057 258.7764165 0.0001734378 2.195249e-03 7.827065e-03 19 41906457 41906575 119 + 2.292 2.369 0.257
ENSG00000076928 E058 151.9094289 0.0017546362 1.291892e-02 3.572295e-02 19 41906576 41906620 45 + 2.049 2.146 0.324
ENSG00000076928 E059 3.7160501 0.0046655563 9.126664e-01 9.486553e-01 19 41906621 41906702 82 + 0.604 0.620 0.071
ENSG00000076928 E060 246.4111686 0.0017739236 1.245324e-05 8.095352e-05 19 41906703 41906803 101 + 2.219 2.366 0.490
ENSG00000076928 E061 330.8643460 0.0054857717 8.462204e-03 2.494265e-02 19 41907105 41907454 350 + 2.376 2.489 0.377
ENSG00000076928 E062 0.0000000       19 41923092 41923093 2 +      
ENSG00000076928 E063 0.0000000       19 41923094 41923233 140 +      
ENSG00000076928 E064 0.4448795 0.5780188661 5.885273e-01 7.117215e-01 19 41928590 41928722 133 + 0.000 0.202 10.515
ENSG00000076928 E065 0.1515154 0.0427681145 2.036097e-01   19 41928820 41928830 11 + 0.177 0.000 -11.803
ENSG00000076928 E066 0.1515154 0.0427681145 2.036097e-01   19 41928831 41928853 23 + 0.177 0.000 -11.803
ENSG00000076928 E067 0.3332198 0.0274424043 5.276458e-01   19 41928854 41928986 133 + 0.177 0.083 -1.252
ENSG00000076928 E068 2.0218912 0.0072974655 3.034477e-01 4.453602e-01 19 41929655 41930150 496 + 0.302 0.492 1.068