ENSG00000076685

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343289 ENSG00000076685 HEK293_OSMI2_2hA HEK293_TMG_2hB NT5C2 protein_coding protein_coding 18.99501 10.39136 24.56198 1.14936 0.6126004 1.240243 6.2190243 4.54902346 6.448582 1.30867967 0.2103653 0.5024927 0.34062917 0.42176667 0.26266667 -0.15910000 0.2527668448 0.0002669046 FALSE TRUE
ENST00000404739 ENSG00000076685 HEK293_OSMI2_2hA HEK293_TMG_2hB NT5C2 protein_coding protein_coding 18.99501 10.39136 24.56198 1.14936 0.6126004 1.240243 3.4157698 0.64664651 5.803938 0.19918779 0.5124109 3.1463267 0.15527083 0.06743333 0.23670000 0.16926667 0.0096516214 0.0002669046 FALSE TRUE
ENST00000675645 ENSG00000076685 HEK293_OSMI2_2hA HEK293_TMG_2hB NT5C2 protein_coding protein_coding 18.99501 10.39136 24.56198 1.14936 0.6126004 1.240243 0.6436339 0.06781648 1.648929 0.06781648 0.3855204 4.4140325 0.02477083 0.00770000 0.06690000 0.05920000 0.0590474825 0.0002669046 FALSE TRUE
MSTRG.4575.30 ENSG00000076685 HEK293_OSMI2_2hA HEK293_TMG_2hB NT5C2 protein_coding   18.99501 10.39136 24.56198 1.14936 0.6126004 1.240243 1.3529949 1.87036019 1.078607 0.16501781 0.2338331 -0.7885256 0.09325417 0.18746667 0.04356667 -0.14390000 0.0002669046 0.0002669046   FALSE
MSTRG.4575.6 ENSG00000076685 HEK293_OSMI2_2hA HEK293_TMG_2hB NT5C2 protein_coding   18.99501 10.39136 24.56198 1.14936 0.6126004 1.240243 2.7698652 1.86526200 2.798189 0.24070070 0.4091304 0.5825480 0.15448333 0.18140000 0.11336667 -0.06803333 0.1768813467 0.0002669046 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000076685 E001 0.2955422 0.0279156104 5.684086e-01   10 103087185 103087256 72 - 0.085 0.173 1.179
ENSG00000076685 E002 2.8064020 0.0762484015 3.355414e-01 4.793301e-01 10 103087257 103088017 761 - 0.627 0.467 -0.748
ENSG00000076685 E003 0.1472490 0.0442660514 1.000000e+00   10 103088018 103088037 20 - 0.085 0.000 -10.169
ENSG00000076685 E004 0.7341808 0.0207247294 7.016249e-01 8.007016e-01 10 103088038 103088059 22 - 0.217 0.296 0.593
ENSG00000076685 E005 1.8444427 0.0089935520 1.972047e-01 3.227305e-01 10 103088060 103088071 12 - 0.361 0.595 1.179
ENSG00000076685 E006 9.1026638 0.0273929895 8.748023e-03 2.565499e-02 10 103088072 103088119 48 - 0.835 1.202 1.352
ENSG00000076685 E007 15.8513585 0.0621180141 1.182907e-02 3.312081e-02 10 103088120 103088163 44 - 1.040 1.423 1.354
ENSG00000076685 E008 17.0611271 0.0700405395 2.835168e-02 6.871015e-02 10 103088164 103088170 7 - 1.104 1.420 1.110
ENSG00000076685 E009 21.5000082 0.0449292235 1.877357e-03 6.844651e-03 10 103088171 103088180 10 - 1.160 1.549 1.356
ENSG00000076685 E010 20.5411494 0.0391162467 3.899736e-03 1.286245e-02 10 103088181 103088182 2 - 1.159 1.518 1.251
ENSG00000076685 E011 132.8611181 0.0097163060 2.764190e-05 1.657963e-04 10 103088183 103088481 299 - 2.005 2.259 0.851
ENSG00000076685 E012 43.5866547 0.0008972137 9.262887e-06 6.205185e-05 10 103088482 103088483 2 - 1.532 1.790 0.875
ENSG00000076685 E013 60.8480523 0.0031729491 9.149560e-05 4.819967e-04 10 103088484 103088501 18 - 1.688 1.912 0.757
ENSG00000076685 E014 57.1728759 0.0138574522 3.333279e-02 7.844857e-02 10 103088502 103088516 15 - 1.678 1.861 0.619
ENSG00000076685 E015 103.4419123 0.0005826467 2.866138e-07 2.664023e-06 10 103088517 103088648 132 - 1.926 2.130 0.683
ENSG00000076685 E016 528.1513795 0.0012920616 4.176018e-02 9.429264e-02 10 103088649 103089840 1192 - 2.686 2.745 0.195
ENSG00000076685 E017 97.8806252 0.0164867112 7.139859e-02 1.456550e-01 10 103089841 103089908 68 - 2.013 1.907 -0.358
ENSG00000076685 E018 65.3789349 0.0017863216 2.127992e-01 3.418354e-01 10 103090611 103090638 28 - 1.823 1.779 -0.147
ENSG00000076685 E019 114.0955226 0.0002600883 4.853731e-01 6.232460e-01 10 103090639 103090787 149 - 2.048 2.042 -0.019
ENSG00000076685 E020 86.9166470 0.0012351446 1.848989e-01 3.073594e-01 10 103090936 103090996 61 - 1.938 1.897 -0.140
ENSG00000076685 E021 83.0961543 0.0003501508 1.868845e-01 3.098199e-01 10 103091564 103091615 52 - 1.920 1.883 -0.122
ENSG00000076685 E022 129.6240397 0.0005616253 3.428261e-03 1.151917e-02 10 103093139 103093272 134 - 2.125 2.040 -0.282
ENSG00000076685 E023 67.4694263 0.0044736601 9.999490e-02 1.904831e-01 10 103093273 103093309 37 - 1.843 1.761 -0.276
ENSG00000076685 E024 1.3328556 0.0097447967 1.541695e-01 2.673356e-01 10 103093732 103093971 240 - 0.436 0.173 -1.820
ENSG00000076685 E025 90.6060559 0.0032231682 1.083690e-01 2.031264e-01 10 103093972 103094038 67 - 1.965 1.901 -0.214
ENSG00000076685 E026 104.1695800 0.0003161057 8.059655e-03 2.393112e-02 10 103094348 103094455 108 - 2.032 1.952 -0.268
ENSG00000076685 E027 0.4449813 0.0217681645 1.000000e+00 1.000000e+00 10 103094456 103094535 80 - 0.156 0.173 0.179
ENSG00000076685 E028 62.3716503 0.0004742561 1.084906e-03 4.252421e-03 10 103095939 103095980 42 - 1.831 1.690 -0.476
ENSG00000076685 E029 45.9416065 0.0005063827 1.051074e-01 1.982486e-01 10 103097291 103097307 17 - 1.680 1.609 -0.241
ENSG00000076685 E030 61.0924780 0.0005599435 3.287154e-01 4.721959e-01 10 103097308 103097374 67 - 1.787 1.758 -0.098
ENSG00000076685 E031 12.3584365 0.0415916981 1.648242e-03 6.115204e-03 10 103097375 103097971 597 - 1.219 0.736 -1.806
ENSG00000076685 E032 3.4518137 0.0829036658 3.386680e-02 7.949011e-02 10 103097972 103098047 76 - 0.742 0.297 -2.205
ENSG00000076685 E033 3.1667920 0.0059529104 7.242469e-02 1.473753e-01 10 103098048 103098088 41 - 0.689 0.393 -1.404
ENSG00000076685 E034 7.2477075 0.0304756061 6.799073e-02 1.400320e-01 10 103098089 103098391 303 - 0.974 0.694 -1.096
ENSG00000076685 E035 10.8667328 0.0063279523 2.135548e-05 1.315386e-04 10 103098392 103098930 539 - 1.183 0.646 -2.057
ENSG00000076685 E036 48.8145255 0.0072793273 4.642072e-01 6.039645e-01 10 103098931 103098970 40 - 1.694 1.657 -0.126
ENSG00000076685 E037 42.1874139 0.0005523893 3.826097e-01 5.268135e-01 10 103098971 103098984 14 - 1.630 1.599 -0.108
ENSG00000076685 E038 90.1089492 0.0057343810 6.276652e-01 7.434247e-01 10 103099926 103100019 94 - 1.947 1.925 -0.072
ENSG00000076685 E039 4.1192975 0.0049793178 1.344642e-01 2.403647e-01 10 103100752 103100867 116 - 0.760 0.538 -0.956
ENSG00000076685 E040 3.4633653 0.0143982258 3.090996e-01 4.513744e-01 10 103100868 103100943 76 - 0.689 0.537 -0.669
ENSG00000076685 E041 1.6544221 0.0081419238 7.914959e-02 1.581548e-01 10 103100944 103100964 21 - 0.500 0.173 -2.140
ENSG00000076685 E042 82.8658928 0.0003819974 1.588101e-02 4.247108e-02 10 103101045 103101102 58 - 1.932 1.849 -0.280
ENSG00000076685 E043 98.5045307 0.0003548097 4.313411e-03 1.402226e-02 10 103101235 103101326 92 - 2.010 1.918 -0.309
ENSG00000076685 E044 9.8787532 0.0020065849 8.918444e-01 9.349221e-01 10 103105358 103105381 24 - 1.003 1.034 0.112
ENSG00000076685 E045 102.7595622 0.0003161363 1.294026e-03 4.956116e-03 10 103105706 103105801 96 - 2.032 1.928 -0.347
ENSG00000076685 E046 103.0104017 0.0003279265 4.753796e-04 2.065958e-03 10 103106589 103106706 118 - 2.038 1.925 -0.379
ENSG00000076685 E047 0.1515154 0.0435370586 1.000000e+00   10 103111693 103111744 52 - 0.085 0.000 -10.176
ENSG00000076685 E048 3.2443241 0.0054353466 7.336881e-02 1.489142e-01 10 103111745 103111805 61 - 0.689 0.393 -1.403
ENSG00000076685 E049 0.6696487 0.0311524353 8.129237e-01 8.813794e-01 10 103136249 103136372 124 - 0.217 0.174 -0.401
ENSG00000076685 E050 65.5838274 0.0007524572 1.198133e-03 4.634185e-03 10 103139406 103139479 74 - 1.853 1.715 -0.465
ENSG00000076685 E051 0.0000000       10 103140117 103140192 76 -      
ENSG00000076685 E052 7.9993900 0.0034348300 1.989982e-08 2.321049e-07 10 103143068 103143168 101 - 0.581 1.247 2.568
ENSG00000076685 E053 0.0000000       10 103153291 103153627 337 -      
ENSG00000076685 E054 2.0962048 0.1805435646 4.604066e-01 6.004505e-01 10 103169284 103169449 166 - 0.400 0.595 0.957
ENSG00000076685 E055 91.9201702 0.0009929114 3.798269e-01 5.240817e-01 10 103174858 103174982 125 - 1.934 1.986 0.175
ENSG00000076685 E056 1.6627514 0.0081333665 3.479299e-01 4.921473e-01 10 103176486 103176899 414 - 0.361 0.537 0.916
ENSG00000076685 E057 22.5542620 0.0276111185 6.775279e-01 7.822262e-01 10 103181185 103181230 46 - 1.367 1.316 -0.175
ENSG00000076685 E058 35.1259679 0.0056916599 9.438162e-01 9.687552e-01 10 103181231 103181328 98 - 1.532 1.548 0.052
ENSG00000076685 E059 0.7374030 0.0155025543 5.790354e-01 7.040178e-01 10 103187125 103187246 122 - 0.271 0.173 -0.820
ENSG00000076685 E060 36.8872218 0.0005815896 3.306779e-01 4.742802e-01 10 103193236 103193306 71 - 1.577 1.535 -0.141
ENSG00000076685 E061 0.0000000       10 103197765 103197857 93 -      
ENSG00000076685 E062 1.9208275 0.0094865341 5.697280e-03 1.780930e-02 10 103199296 103199407 112 - 0.217 0.692 2.597
ENSG00000076685 E063 1.0318985 0.0160727504 8.200195e-02 1.626823e-01 10 103199408 103199505 98 - 0.156 0.471 2.182
ENSG00000076685 E064 0.1817044 0.0435422333 2.177526e-01   10 103276216 103276832 617 - 0.000 0.173 10.809
ENSG00000076685 E065 5.4805521 0.0031909543 3.031925e-01 4.450869e-01 10 103277154 103277662 509 - 0.743 0.895 0.595