ENSG00000076650

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000170564 ENSG00000076650 HEK293_OSMI2_2hA HEK293_TMG_2hB GPATCH1 protein_coding protein_coding 8.112036 5.592191 9.959783 0.5393956 0.4209381 0.8315709 6.4075080 4.9000417 7.2085350 0.38790911 0.37351880 0.5559708 0.8134125 0.87966667 0.72546667 -0.15420000 0.0246518 0.0246518 FALSE TRUE
ENST00000590062 ENSG00000076650 HEK293_OSMI2_2hA HEK293_TMG_2hB GPATCH1 protein_coding retained_intron 8.112036 5.592191 9.959783 0.5393956 0.4209381 0.8315709 1.0145807 0.4239473 1.7526146 0.16923050 0.44825558 2.0221253 0.1038375 0.07523333 0.17436667 0.09913333 0.2494536 0.0246518 FALSE TRUE
ENST00000592262 ENSG00000076650 HEK293_OSMI2_2hA HEK293_TMG_2hB GPATCH1 protein_coding retained_intron 8.112036 5.592191 9.959783 0.5393956 0.4209381 0.8315709 0.5535701 0.1958107 0.7421511 0.07434141 0.04630525 1.8697049 0.0679125 0.03323333 0.07446667 0.04123333 0.1124351 0.0246518 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000076650 E001 2.425147 0.0146214609 6.437474e-01 7.562207e-01 19 33080899 33081180 282 + 0.584 0.509 -0.347
ENSG00000076650 E002 24.843028 0.0171133927 2.564671e-01 3.934323e-01 19 33081181 33081266 86 + 1.464 1.369 -0.329
ENSG00000076650 E003 40.441453 0.0162987504 4.638306e-02 1.027302e-01 19 33088134 33088268 135 + 1.690 1.536 -0.523
ENSG00000076650 E004 40.755757 0.0005376811 3.962331e-04 1.759945e-03 19 33090780 33090865 86 + 1.707 1.514 -0.657
ENSG00000076650 E005 61.145464 0.0013027807 1.047784e-02 2.992607e-02 19 33093359 33093519 161 + 1.852 1.734 -0.397
ENSG00000076650 E006 48.112815 0.0032052597 1.099660e-01 2.054936e-01 19 33094172 33094269 98 + 1.733 1.642 -0.307
ENSG00000076650 E007 41.507452 0.0005578574 2.996539e-03 1.025369e-02 19 33095762 33095820 59 + 1.702 1.543 -0.542
ENSG00000076650 E008 69.684833 0.0004293295 2.232674e-04 1.063148e-03 19 33096207 33096446 240 + 1.918 1.764 -0.519
ENSG00000076650 E009 49.708849 0.0125661650 4.549215e-01 5.955043e-01 19 33097755 33097902 148 + 1.732 1.669 -0.214
ENSG00000076650 E010 0.147249 0.0443999534 6.347283e-01   19 33100173 33100274 102 + 0.109 0.000 -8.463
ENSG00000076650 E011 37.135240 0.0160239699 7.981995e-01 8.711991e-01 19 33101495 33101574 80 + 1.575 1.585 0.035
ENSG00000076650 E012 59.044406 0.0004730918 1.249089e-01 2.269957e-01 19 33106695 33106899 205 + 1.812 1.744 -0.230
ENSG00000076650 E013 51.947011 0.0004794689 4.963785e-01 6.330611e-01 19 33109717 33109876 160 + 1.744 1.713 -0.104
ENSG00000076650 E014 50.422694 0.0121022692 9.484631e-01 9.716876e-01 19 33109877 33110016 140 + 1.710 1.718 0.028
ENSG00000076650 E015 56.475262 0.0009075301 1.638658e-01 2.801819e-01 19 33111724 33111902 179 + 1.793 1.729 -0.216
ENSG00000076650 E016 58.622431 0.0015005522 4.775500e-01 6.160833e-01 19 33112486 33112613 128 + 1.795 1.763 -0.107
ENSG00000076650 E017 3.333294 0.0661103574 2.780077e-01 4.176399e-01 19 33112614 33112679 66 + 0.721 0.511 -0.925
ENSG00000076650 E018 11.197347 0.0015912550 8.312007e-07 7.023885e-06 19 33112939 33113766 828 + 1.270 0.738 -1.976
ENSG00000076650 E019 65.500653 0.0004104889 2.218399e-01 3.525954e-01 19 33113767 33113903 137 + 1.799 1.852 0.180
ENSG00000076650 E020 79.900333 0.0007122157 2.074602e-03 7.455274e-03 19 33114253 33114419 167 + 1.845 1.967 0.411
ENSG00000076650 E021 90.281570 0.0051414760 4.116648e-03 1.347001e-02 19 33117825 33118041 217 + 1.890 2.027 0.458
ENSG00000076650 E022 43.938309 0.0110612784 1.471898e-01 2.578570e-01 19 33119010 33119117 108 + 1.601 1.701 0.339
ENSG00000076650 E023 35.201139 0.0058245782 4.670937e-01 6.066118e-01 19 33125105 33125202 98 + 1.541 1.593 0.176
ENSG00000076650 E024 55.374762 0.0004996768 2.045115e-08 2.380443e-07 19 33126588 33126733 146 + 1.613 1.876 0.890
ENSG00000076650 E025 57.769268 0.0007889957 4.272218e-14 1.280226e-12 19 33130130 33130542 413 + 1.572 1.928 1.205