ENSG00000076555

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396233 ENSG00000076555 HEK293_OSMI2_2hA HEK293_TMG_2hB ACACB protein_coding retained_intron 4.15181 4.715539 3.858692 0.2452197 0.1877023 -0.2886331 0.4005759 0.1876572 0.4387745 0.04169204 0.09200977 1.1829903 0.09711250 0.04046667 0.11306667 0.07260000 0.06152714 0.0004505 FALSE FALSE
ENST00000536440 ENSG00000076555 HEK293_OSMI2_2hA HEK293_TMG_2hB ACACB protein_coding nonsense_mediated_decay 4.15181 4.715539 3.858692 0.2452197 0.1877023 -0.2886331 0.2228168 0.2625367 0.2973469 0.07684920 0.16975351 0.1734176 0.05066250 0.05760000 0.07353333 0.01593333 0.95725304 0.0004505 TRUE TRUE
ENST00000538526 ENSG00000076555 HEK293_OSMI2_2hA HEK293_TMG_2hB ACACB protein_coding nonsense_mediated_decay 4.15181 4.715539 3.858692 0.2452197 0.1877023 -0.2886331 0.9672861 1.7898732 0.1400449 0.26628013 0.07649213 -3.5844287 0.21177917 0.38150000 0.03463333 -0.34686667 0.00045050 0.0004505 TRUE TRUE
ENST00000544651 ENSG00000076555 HEK293_OSMI2_2hA HEK293_TMG_2hB ACACB protein_coding retained_intron 4.15181 4.715539 3.858692 0.2452197 0.1877023 -0.2886331 0.1088520 0.0000000 0.2030242 0.00000000 0.20302422 4.4129456 0.02200000 0.00000000 0.05676667 0.05676667 0.79949725 0.0004505   FALSE
MSTRG.7978.10 ENSG00000076555 HEK293_OSMI2_2hA HEK293_TMG_2hB ACACB protein_coding   4.15181 4.715539 3.858692 0.2452197 0.1877023 -0.2886331 0.2519843 0.0000000 0.3515379 0.00000000 0.23842480 5.1760749 0.07487083 0.00000000 0.09063333 0.09063333 0.19552013 0.0004505 FALSE TRUE
MSTRG.7978.7 ENSG00000076555 HEK293_OSMI2_2hA HEK293_TMG_2hB ACACB protein_coding   4.15181 4.715539 3.858692 0.2452197 0.1877023 -0.2886331 1.2476882 1.1978102 1.4697728 0.24829935 0.24038996 0.2929819 0.30777917 0.25100000 0.37676667 0.12576667 0.33141723 0.0004505 FALSE TRUE
MSTRG.7978.9 ENSG00000076555 HEK293_OSMI2_2hA HEK293_TMG_2hB ACACB protein_coding   4.15181 4.715539 3.858692 0.2452197 0.1877023 -0.2886331 0.5693540 0.6009359 0.2732347 0.16977801 0.27323471 -1.1090230 0.14262500 0.13063333 0.07640000 -0.05423333 0.35408499 0.0004505 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000076555 E001 0.0000000       12 109116587 109116704 118 +      
ENSG00000076555 E002 0.0000000       12 109131358 109131426 69 +      
ENSG00000076555 E003 1.0611596 0.0894102418 3.942522e-02 8.996723e-02 12 109139397 109139978 582 + 0.492 0.114 -2.805
ENSG00000076555 E004 0.5954526 0.0183557928 2.252660e-02 5.677486e-02 12 109139979 109140058 80 + 0.381 0.000 -13.031
ENSG00000076555 E005 1.1813256 0.0495058410 1.814654e-01 3.030855e-01 12 109154623 109154681 59 + 0.441 0.206 -1.535
ENSG00000076555 E006 4.5706280 0.0046175602 4.715642e-01 6.106759e-01 12 109154682 109154756 75 + 0.773 0.692 -0.328
ENSG00000076555 E007 5.1523760 0.0089144770 2.807024e-01 4.205774e-01 12 109154757 109154793 37 + 0.844 0.718 -0.500
ENSG00000076555 E008 9.8908771 0.0220515208 4.279371e-01 5.707646e-01 12 109154794 109154940 147 + 1.062 0.992 -0.257
ENSG00000076555 E009 11.8900930 0.0063768876 9.564565e-01 9.767234e-01 12 109166861 109166993 133 + 1.088 1.106 0.065
ENSG00000076555 E010 0.1515154 0.0428844150 4.026043e-01   12 109166994 109167280 287 + 0.131 0.000 -10.946
ENSG00000076555 E011 11.9393393 0.0451256052 6.517509e-01 7.625604e-01 12 109167896 109168034 139 + 1.125 1.095 -0.108
ENSG00000076555 E012 13.2135247 0.0779034273 3.799563e-01 5.242307e-01 12 109171805 109171914 110 + 1.189 1.111 -0.278
ENSG00000076555 E013 10.5722079 0.1037391020 2.159448e-01 3.455390e-01 12 109172275 109172356 82 + 1.136 0.984 -0.554
ENSG00000076555 E014 9.9735080 0.0778057345 2.653054e-01 4.033425e-01 12 109174132 109174230 99 + 1.101 0.970 -0.479
ENSG00000076555 E015 8.5331613 0.1189732292 1.883253e-01 3.116230e-01 12 109175931 109175976 46 + 1.063 0.891 -0.640
ENSG00000076555 E016 8.8966482 0.1345229901 5.612845e-02 1.199288e-01 12 109175977 109176040 64 + 1.135 0.838 -1.104
ENSG00000076555 E017 12.7312885 0.0013611830 1.338500e-04 6.759834e-04 12 109176153 109176263 111 + 1.293 0.961 -1.196
ENSG00000076555 E018 18.9610387 0.0011040325 4.174743e-02 9.427060e-02 12 109179088 109179297 210 + 1.371 1.237 -0.469
ENSG00000076555 E019 0.6558305 0.0557978190 8.343455e-01 8.962794e-01 12 109179298 109179371 74 + 0.231 0.205 -0.221
ENSG00000076555 E020 17.2776476 0.0010540163 1.002277e-01 1.908256e-01 12 109179917 109180087 171 + 1.316 1.206 -0.387
ENSG00000076555 E021 16.0717372 0.0012703602 4.872986e-03 1.557650e-02 12 109185579 109185740 162 + 1.337 1.125 -0.749
ENSG00000076555 E022 21.6165916 0.0022411302 1.901505e-02 4.936613e-02 12 109187999 109188162 164 + 1.432 1.280 -0.526
ENSG00000076555 E023 0.2903454 0.4545930252 2.493211e-01   12 109191478 109191612 135 + 0.230 0.000 -10.862
ENSG00000076555 E024 21.6070016 0.0009482466 1.009238e-02 2.898947e-02 12 109191613 109191763 151 + 1.437 1.273 -0.570
ENSG00000076555 E025 16.6131196 0.0011500928 8.383487e-02 1.655541e-01 12 109191847 109191950 104 + 1.301 1.181 -0.423
ENSG00000076555 E026 13.8331065 0.0014608718 7.803495e-01 8.588368e-01 12 109193648 109193729 82 + 1.157 1.154 -0.011
ENSG00000076555 E027 18.7970347 0.0010354618 2.687974e-01 4.072721e-01 12 109197008 109197153 146 + 1.323 1.259 -0.223
ENSG00000076555 E028 21.6126297 0.0009049257 4.495172e-01 5.907180e-01 12 109199402 109199552 151 + 1.365 1.332 -0.113
ENSG00000076555 E029 19.0581073 0.0009856912 3.504939e-01 4.946661e-01 12 109201567 109201701 135 + 1.323 1.274 -0.173
ENSG00000076555 E030 20.3628623 0.0009947231 1.538408e-01 2.668927e-01 12 109206710 109206856 147 + 1.371 1.287 -0.293
ENSG00000076555 E031 0.8804848 0.2345653091 5.655701e-01 6.926461e-01 12 109207002 109207057 56 + 0.312 0.210 -0.761
ENSG00000076555 E032 15.4058329 0.0093527184 6.088505e-02 1.281240e-01 12 109209165 109209353 189 + 1.285 1.128 -0.558
ENSG00000076555 E033 15.9082527 0.0122840732 5.095308e-02 1.108612e-01 12 109212836 109212936 101 + 1.308 1.146 -0.575
ENSG00000076555 E034 13.4036964 0.0108734208 3.486321e-01 4.928609e-01 12 109216618 109216706 89 + 1.188 1.117 -0.254
ENSG00000076555 E035 17.2953786 0.0010609858 1.457081e-01 2.558125e-01 12 109216796 109216920 125 + 1.308 1.214 -0.332
ENSG00000076555 E036 17.0673897 0.0010849032 1.451539e-01 2.550475e-01 12 109222507 109222620 114 + 1.308 1.214 -0.333
ENSG00000076555 E037 15.9655585 0.0012851252 2.204830e-01 3.509893e-01 12 109222799 109222912 114 + 1.269 1.189 -0.282
ENSG00000076555 E038 11.8035927 0.0161524771 3.304511e-01 4.740350e-01 12 109223815 109223904 90 + 1.147 1.063 -0.302
ENSG00000076555 E039 14.1257100 0.0541412174 3.839772e-01 5.281762e-01 12 109227371 109227489 119 + 1.218 1.132 -0.305
ENSG00000076555 E040 18.1821463 0.0011096248 6.486086e-02 1.348083e-01 12 109232669 109232806 138 + 1.344 1.222 -0.430
ENSG00000076555 E041 12.8043587 0.0013939398 1.727416e-01 2.917662e-01 12 109233748 109233847 100 + 1.188 1.084 -0.371
ENSG00000076555 E042 13.6980807 0.0013051711 2.039233e-01 3.310992e-01 12 109233938 109234045 108 + 1.207 1.116 -0.327
ENSG00000076555 E043 0.0000000       12 109235307 109235312 6 +      
ENSG00000076555 E044 12.1129259 0.0015742945 3.725469e-01 5.169898e-01 12 109235313 109235369 57 + 1.146 1.084 -0.223
ENSG00000076555 E045 12.5808346 0.0015794709 4.986803e-01 6.351158e-01 12 109235606 109235647 42 + 1.146 1.106 -0.147
ENSG00000076555 E046 0.0000000       12 109235648 109236377 730 +      
ENSG00000076555 E047 27.3980088 0.0008775025 6.653724e-01 7.730598e-01 12 109237165 109237380 216 + 1.454 1.449 -0.017
ENSG00000076555 E048 29.8852615 0.0007253700 2.043620e-01 3.316155e-01 12 109239830 109239985 156 + 1.518 1.462 -0.192
ENSG00000076555 E049 23.1893722 0.0011129306 1.865925e-01 3.094634e-01 12 109241078 109241222 145 + 1.420 1.350 -0.244
ENSG00000076555 E050 19.7677371 0.0009901566 2.223655e-01 3.532203e-01 12 109241223 109241281 59 + 1.344 1.274 -0.247
ENSG00000076555 E051 0.0000000       12 109241670 109242436 767 +      
ENSG00000076555 E052 29.0599125 0.0161045077 6.173893e-01 7.352127e-01 12 109242437 109242592 156 + 1.475 1.455 -0.069
ENSG00000076555 E053 0.5546650 0.0205046804 6.935743e-01 7.946031e-01 12 109242593 109242667 75 + 0.131 0.205 0.779
ENSG00000076555 E054 23.1455698 0.0009432462 5.204118e-01 6.543771e-01 12 109245626 109245713 88 + 1.330 1.400 0.241
ENSG00000076555 E055 16.0586895 0.0015474510 3.749176e-01 5.193552e-01 12 109245714 109245748 35 + 1.168 1.266 0.349
ENSG00000076555 E056 31.9008720 0.0006686515 1.601128e-01 2.752705e-01 12 109246179 109246448 270 + 1.437 1.548 0.381
ENSG00000076555 E057 15.6710041 0.0012109859 9.851816e-01 9.947486e-01 12 109247606 109247703 98 + 1.198 1.222 0.085
ENSG00000076555 E058 6.9152237 0.0034499735 2.021710e-02 5.194214e-02 12 109248958 109249983 1026 + 1.021 0.765 -0.977
ENSG00000076555 E059 27.0457739 0.0010570841 6.751259e-01 7.804867e-01 12 109249984 109250104 121 + 1.448 1.444 -0.015
ENSG00000076555 E060 28.8229424 0.0007277188 5.802614e-02 1.232524e-01 12 109252046 109252156 111 + 1.378 1.525 0.509
ENSG00000076555 E061 4.3832101 0.1658596429 9.224702e-01 9.550937e-01 12 109252157 109252578 422 + 0.745 0.729 -0.066
ENSG00000076555 E062 32.3598720 0.0006617011 2.867112e-01 4.271301e-01 12 109253015 109253158 144 + 1.459 1.548 0.306
ENSG00000076555 E063 27.0257822 0.0007899735 4.783265e-01 6.167520e-01 12 109254214 109254334 121 + 1.396 1.467 0.244
ENSG00000076555 E064 20.7403721 0.0010183582 7.269882e-01 8.198693e-01 12 109256140 109256236 97 + 1.301 1.350 0.172
ENSG00000076555 E065 23.8133088 0.0008769991 8.562465e-01 9.111163e-01 12 109258268 109258364 97 + 1.384 1.394 0.036
ENSG00000076555 E066 28.8255534 0.0008532206 8.910874e-01 9.344542e-01 12 109258973 109259108 136 + 1.448 1.480 0.110
ENSG00000076555 E067 1.4487803 0.0106287276 5.237893e-01 6.574200e-01 12 109260065 109260149 85 + 0.441 0.343 -0.546
ENSG00000076555 E068 32.2835818 0.0018828004 3.588341e-01 5.032167e-01 12 109260480 109260657 178 + 1.532 1.498 -0.118
ENSG00000076555 E069 25.7013155 0.0088106871 7.174226e-01 8.128024e-01 12 109262357 109262469 113 + 1.420 1.416 -0.012
ENSG00000076555 E070 0.9650892 0.0361997596 5.843549e-01 7.083170e-01 12 109263022 109264231 1210 + 0.231 0.342 0.771
ENSG00000076555 E071 30.3956015 0.0010919736 5.870793e-02 1.244174e-01 12 109264232 109264386 155 + 1.402 1.548 0.501
ENSG00000076555 E072 36.4784682 0.0010367652 4.111997e-02 9.310983e-02 12 109265110 109265280 171 + 1.475 1.620 0.496
ENSG00000076555 E073 33.3687377 0.0123004668 1.188624e-01 2.183169e-01 12 109265389 109265525 137 + 1.432 1.580 0.508
ENSG00000076555 E074 223.0914998 0.0065360053 1.065428e-14 3.488458e-13 12 109266236 109268226 1991 + 2.107 2.457 1.167