ENSG00000076513

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261739 ENSG00000076513 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13A protein_coding protein_coding 13.17407 10.27449 17.10952 2.194932 0.5042068 0.7351721 2.7436812 0.8378204 6.0844565 0.44048388 0.1676325 2.84566691 0.19310833 0.08106667 0.3557333 0.27466667 1.378909e-01 4.811418e-24 FALSE TRUE
ENST00000546476 ENSG00000076513 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13A protein_coding retained_intron 13.17407 10.27449 17.10952 2.194932 0.5042068 0.7351721 0.6416855 0.2252838 0.6366158 0.09292049 0.1705031 1.45850706 0.05071667 0.02346667 0.0367000 0.01323333 6.108274e-01 4.811418e-24 FALSE FALSE
ENST00000547639 ENSG00000076513 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13A protein_coding protein_coding 13.17407 10.27449 17.10952 2.194932 0.5042068 0.7351721 0.8103247 0.0000000 2.5701250 0.00000000 0.1324152 8.01129715 0.04627083 0.00000000 0.1506333 0.15063333 4.811418e-24 4.811418e-24 FALSE TRUE
ENST00000553246 ENSG00000076513 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13A protein_coding retained_intron 13.17407 10.27449 17.10952 2.194932 0.5042068 0.7351721 0.6828609 2.1284811 0.0214084 1.40368189 0.0214084 -6.08929218 0.06312500 0.17950000 0.0012000 -0.17830000 1.515998e-01 4.811418e-24 FALSE FALSE
MSTRG.7997.1 ENSG00000076513 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13A protein_coding   13.17407 10.27449 17.10952 2.194932 0.5042068 0.7351721 3.2812460 3.9112272 3.6987895 0.45517480 0.2421525 -0.08035682 0.24384167 0.39550000 0.2160333 -0.17946667 1.482848e-03 4.811418e-24 FALSE TRUE
MSTRG.7997.10 ENSG00000076513 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13A protein_coding   13.17407 10.27449 17.10952 2.194932 0.5042068 0.7351721 1.3067503 0.4758541 2.3588058 0.24207098 0.1642895 2.28556490 0.09226667 0.04266667 0.1384333 0.09576667 2.263592e-01 4.811418e-24 FALSE TRUE
MSTRG.7997.9 ENSG00000076513 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13A protein_coding   13.17407 10.27449 17.10952 2.194932 0.5042068 0.7351721 1.7562878 1.6499081 0.0000000 0.03467578 0.0000000 -7.37495957 0.15402500 0.17486667 0.0000000 -0.17486667 1.877113e-16 4.811418e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000076513 E001 1.2295251 0.1221018804 9.243508e-01 9.563404e-01 12 109999167 109999181 15 + 0.347 0.359 0.074
ENSG00000076513 E002 1.3746978 0.0538015200 7.094157e-01 8.068145e-01 12 109999182 109999185 4 + 0.392 0.361 -0.178
ENSG00000076513 E003 1.3746978 0.0538015200 7.094157e-01 8.068145e-01 12 109999186 109999193 8 + 0.392 0.361 -0.178
ENSG00000076513 E004 2.7774686 0.0063765134 7.166831e-01 8.122615e-01 12 109999194 109999212 19 + 0.566 0.557 -0.042
ENSG00000076513 E005 10.5350525 0.0016719907 5.559525e-02 1.189975e-01 12 109999213 109999319 107 + 1.104 0.966 -0.506
ENSG00000076513 E006 11.2037666 0.0014869929 4.019109e-08 4.418828e-07 12 109999430 109999595 166 + 1.233 0.651 -2.213
ENSG00000076513 E007 13.0928154 0.0064543125 9.436776e-03 2.737442e-02 12 109999596 109999647 52 + 1.214 1.005 -0.753
ENSG00000076513 E008 37.5189491 0.0006060989 5.266531e-07 4.637577e-06 12 109999648 109999784 137 + 1.662 1.425 -0.810
ENSG00000076513 E009 79.5870799 0.0008020790 2.702739e-04 1.258791e-03 12 110012005 110012137 133 + 1.938 1.855 -0.278
ENSG00000076513 E010 97.8810756 0.0008563328 3.283393e-01 4.718274e-01 12 110013125 110013249 125 + 1.982 2.014 0.106
ENSG00000076513 E011 67.1679008 0.0004519083 1.629693e-01 2.790118e-01 12 110016388 110016433 46 + 1.827 1.834 0.025
ENSG00000076513 E012 65.6836259 0.0087214275 1.872364e-01 3.102625e-01 12 110018345 110018383 39 + 1.829 1.805 -0.079
ENSG00000076513 E013 91.7900134 0.0049640907 8.515015e-02 1.676516e-01 12 110018384 110018488 105 + 1.973 1.947 -0.086
ENSG00000076513 E014 114.6563612 0.0004830937 3.475833e-03 1.165483e-02 12 110019139 110019328 190 + 2.071 2.039 -0.108
ENSG00000076513 E015 6.7652700 0.0342412244 5.078462e-01 6.432694e-01 12 110021108 110021301 194 + 0.821 0.965 0.550
ENSG00000076513 E016 9.9837326 0.0279289838 4.121136e-01 5.556687e-01 12 110021302 110022464 1163 + 1.051 0.989 -0.230
ENSG00000076513 E017 5.5295068 0.0122232044 4.509451e-01 5.919621e-01 12 110023619 110024045 427 + 0.836 0.792 -0.173
ENSG00000076513 E018 71.4958744 0.0003845002 3.849907e-05 2.228190e-04 12 110024046 110024112 67 + 1.898 1.791 -0.362
ENSG00000076513 E019 74.3803952 0.0003974486 2.890587e-02 6.981387e-02 12 110025742 110025823 82 + 1.883 1.861 -0.075
ENSG00000076513 E020 38.6667887 0.0036851106 8.972726e-01 9.383984e-01 12 110027705 110027707 3 + 1.572 1.629 0.193
ENSG00000076513 E021 69.5680831 0.0004045846 7.831403e-01 8.607923e-01 12 110027708 110027766 59 + 1.822 1.879 0.191
ENSG00000076513 E022 8.7853399 0.0417000325 7.230489e-01 8.169683e-01 12 110027899 110028508 610 + 0.980 0.971 -0.033
ENSG00000076513 E023 7.2278209 0.0022525355 1.973502e-01 3.229147e-01 12 110028509 110028511 3 + 0.945 0.850 -0.361
ENSG00000076513 E024 71.6527947 0.0005713760 2.886694e-01 4.292822e-01 12 110028512 110028557 46 + 1.848 1.871 0.076
ENSG00000076513 E025 92.3315973 0.0019660378 2.467623e-01 3.821435e-01 12 110028558 110028642 85 + 1.959 1.975 0.054
ENSG00000076513 E026 0.7404218 0.2997694057 2.258895e-01 3.574544e-01 12 110028947 110029477 531 + 0.095 0.423 2.760
ENSG00000076513 E027 70.3139037 0.0004146479 2.262196e-01 3.578633e-01 12 110029478 110029550 73 + 1.845 1.863 0.060
ENSG00000076513 E028 71.8159515 0.0003893022 6.202087e-01 7.374719e-01 12 110029551 110029635 85 + 1.842 1.891 0.163
ENSG00000076513 E029 85.0113922 0.0022066187 1.967232e-01 3.221515e-01 12 110030645 110030758 114 + 1.929 1.939 0.033
ENSG00000076513 E030 90.6974836 0.0003331958 1.927427e-02 4.993099e-02 12 110033797 110033931 135 + 1.968 1.950 -0.063
ENSG00000076513 E031 46.1217536 0.0005084375 7.311954e-02 1.485099e-01 12 110033932 110033957 26 + 1.684 1.660 -0.083
ENSG00000076513 E032 0.4031496 0.0382035561 1.075009e-01 2.018527e-01 12 110036215 110036260 46 + 0.000 0.272 11.368
ENSG00000076513 E033 71.1768253 0.0003926924 4.184951e-02 9.444931e-02 12 110036261 110036328 68 + 1.865 1.848 -0.057
ENSG00000076513 E034 0.5212538 0.0205518708 3.513444e-01 4.955637e-01 12 110036329 110036329 1 + 0.095 0.271 1.831
ENSG00000076513 E035 104.8272199 0.0002826706 1.024735e-01 1.942749e-01 12 110037359 110037525 167 + 2.018 2.030 0.042
ENSG00000076513 E036 648.7612673 0.0092686019 2.071202e-07 1.979732e-06 12 110037526 110039763 2238 + 2.686 2.938 0.838