ENSG00000076201

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265562 ENSG00000076201 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN23 protein_coding protein_coding 24.97648 28.49516 22.27127 1.689088 0.4195885 -0.3553918 12.552369 11.6581278 10.273600 2.1557945 0.1246445 -0.18222772 0.49912917 0.4028000 0.46173333 0.05893333 6.922606e-01 1.343243e-09 FALSE TRUE
ENST00000602307 ENSG00000076201 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN23 protein_coding nonsense_mediated_decay 24.97648 28.49516 22.27127 1.689088 0.4195885 -0.3553918 2.717632 3.8655787 3.630509 0.2121058 0.4147334 -0.09027163 0.11129167 0.1360667 0.16283333 0.02676667 5.964725e-01 1.343243e-09 FALSE TRUE
ENST00000683566 ENSG00000076201 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN23 protein_coding retained_intron 24.97648 28.49516 22.27127 1.689088 0.4195885 -0.3553918 1.797637 0.5882379 2.573952 0.1429077 0.2092125 2.11078797 0.07760833 0.0203000 0.11583333 0.09553333 1.343243e-09 1.343243e-09 FALSE TRUE
ENST00000683708 ENSG00000076201 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN23 protein_coding processed_transcript 24.97648 28.49516 22.27127 1.689088 0.4195885 -0.3553918 4.907033 10.3652787 1.553507 1.3907388 0.1934686 -2.73029278 0.18724167 0.3726000 0.07006667 -0.30253333 9.325220e-06 1.343243e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000076201 E001 5.1125189 0.0066573942 9.947523e-01 1.000000e+00 3 47379559 47381010 1452 + 0.752 0.782 0.119
ENSG00000076201 E002 4.7878319 0.0038169639 9.542629e-01 9.753433e-01 3 47381011 47381013 3 + 0.723 0.759 0.146
ENSG00000076201 E003 5.4917220 0.0029625747 9.101778e-01 9.469014e-01 3 47381014 47381020 7 + 0.778 0.822 0.170
ENSG00000076201 E004 18.9308452 0.0009910034 1.619406e-02 4.315129e-02 3 47381021 47381035 15 + 1.371 1.215 -0.547
ENSG00000076201 E005 34.3387401 0.0145450523 2.845228e-02 6.891692e-02 3 47381036 47381069 34 + 1.609 1.472 -0.468
ENSG00000076201 E006 90.1158551 0.0150323155 9.384400e-03 2.724293e-02 3 47381070 47381180 111 + 2.023 1.891 -0.441
ENSG00000076201 E007 98.8839160 0.0057546726 5.925326e-03 1.841308e-02 3 47396143 47396217 75 + 2.044 1.945 -0.332
ENSG00000076201 E008 0.6192988 0.0232303161 2.068087e-01 3.347256e-01 3 47396218 47396291 74 + 0.316 0.113 -1.855
ENSG00000076201 E009 97.3301731 0.0036959016 6.388622e-04 2.676127e-03 3 47404652 47404779 128 + 2.046 1.927 -0.399
ENSG00000076201 E010 99.2456510 0.0003039055 2.735533e-13 7.313554e-12 3 47405005 47405081 77 + 2.108 1.881 -0.762
ENSG00000076201 E011 5.3124919 0.0035338298 4.362323e-06 3.146503e-05 3 47405082 47405279 198 + 1.042 0.444 -2.492
ENSG00000076201 E012 8.2063781 0.2010462254 1.350544e-02 3.708817e-02 3 47405280 47405748 469 + 1.194 0.673 -1.982
ENSG00000076201 E013 101.3130751 0.0003267468 4.650362e-09 6.101510e-08 3 47405749 47405798 50 + 2.090 1.915 -0.585
ENSG00000076201 E014 72.0282174 0.0005442884 3.653041e-06 2.683399e-05 3 47405915 47405944 30 + 1.937 1.774 -0.548
ENSG00000076201 E015 136.0512643 0.0036645405 1.558351e-04 7.730829e-04 3 47405945 47406046 102 + 2.191 2.071 -0.402
ENSG00000076201 E016 127.1727656 0.0038716780 7.524249e-03 2.257561e-02 3 47406325 47406405 81 + 2.138 2.062 -0.256
ENSG00000076201 E017 159.8179334 0.0002741109 3.079674e-05 1.827174e-04 3 47406481 47406612 132 + 2.241 2.156 -0.284
ENSG00000076201 E018 100.5274817 0.0027884547 5.124202e-02 1.113629e-01 3 47406703 47406750 48 + 2.023 1.975 -0.159
ENSG00000076201 E019 12.8640417 0.0015099653 3.872552e-08 4.269340e-07 3 47406892 47407129 238 + 1.351 0.859 -1.784
ENSG00000076201 E020 98.9973070 0.0081066966 1.531874e-02 4.121115e-02 3 47407130 47407186 57 + 2.043 1.948 -0.318
ENSG00000076201 E021 113.9997401 0.0063105473 8.006398e-03 2.379433e-02 3 47407309 47407367 59 + 2.105 2.009 -0.322
ENSG00000076201 E022 136.0626714 0.0003493263 3.164923e-05 1.872650e-04 3 47407505 47407584 80 + 2.178 2.083 -0.318
ENSG00000076201 E023 186.7716837 0.0002803479 2.781290e-09 3.799994e-08 3 47407697 47407811 115 + 2.328 2.205 -0.412
ENSG00000076201 E024 153.4787297 0.0059884299 8.243938e-04 3.346596e-03 3 47407890 47407955 66 + 2.241 2.128 -0.380
ENSG00000076201 E025 13.4191015 0.0014613928 2.618966e-09 3.594286e-08 3 47407956 47408332 377 + 1.384 0.859 -1.901
ENSG00000076201 E026 200.9702018 0.0028292700 1.312719e-03 5.019694e-03 3 47408345 47408490 146 + 2.337 2.262 -0.251
ENSG00000076201 E027 264.3223625 0.0040472007 2.115768e-01 3.403526e-01 3 47408776 47409087 312 + 2.415 2.411 -0.015
ENSG00000076201 E028 144.2524174 0.0112801896 5.993615e-01 7.207747e-01 3 47409163 47409297 135 + 2.138 2.158 0.069
ENSG00000076201 E029 82.8544978 0.0035450364 2.900372e-01 4.308091e-01 3 47409298 47409317 20 + 1.915 1.902 -0.042
ENSG00000076201 E030 2.4960939 0.0372339228 4.919362e-01 6.291674e-01 3 47409318 47409416 99 + 0.586 0.489 -0.456
ENSG00000076201 E031 136.9099536 0.0008723326 3.184230e-01 4.613959e-01 3 47409417 47409545 129 + 2.122 2.124 0.006
ENSG00000076201 E032 70.0778422 0.0014379998 1.614489e-02 4.305054e-02 3 47409546 47409568 23 + 1.883 1.808 -0.255
ENSG00000076201 E033 8.9182074 0.0020167613 2.922880e-04 1.348393e-03 3 47409569 47409654 86 + 1.164 0.802 -1.349
ENSG00000076201 E034 143.8292576 0.0088363504 2.515034e-01 3.877533e-01 3 47409655 47409834 180 + 2.163 2.141 -0.075
ENSG00000076201 E035 365.6989920 0.0001524635 4.513615e-02 1.004406e-01 3 47409928 47411038 1111 + 2.505 2.578 0.241
ENSG00000076201 E036 424.3010975 0.0038570080 2.367449e-07 2.236826e-06 3 47411039 47411686 648 + 2.481 2.693 0.706
ENSG00000076201 E037 238.6891717 0.0018147814 3.753106e-07 3.402147e-06 3 47411783 47411967 185 + 2.245 2.438 0.644
ENSG00000076201 E038 173.7032347 0.0016643139 2.190482e-07 2.083966e-06 3 47412094 47412198 105 + 2.094 2.305 0.705
ENSG00000076201 E039 181.6000160 0.0033051930 1.091475e-08 1.336285e-07 3 47412283 47412421 139 + 2.081 2.340 0.867
ENSG00000076201 E040 159.3881408 0.0018654944 2.737935e-13 7.318944e-12 3 47412514 47412627 114 + 1.991 2.292 1.010
ENSG00000076201 E041 28.6560277 0.0008786358 5.112686e-05 2.874389e-04 3 47412628 47412705 78 + 1.250 1.566 1.094
ENSG00000076201 E042 532.9040370 0.0156263287 2.632130e-07 2.464290e-06 3 47412706 47413471 766 + 2.485 2.829 1.144