ENSG00000076003

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264156 ENSG00000076003 HEK293_OSMI2_2hA HEK293_TMG_2hB MCM6 protein_coding protein_coding 98.95511 67.10495 115.8365 7.661746 1.944085 0.7875089 5.047668 3.495249 7.050481 0.6064506 0.8418903 1.0102498 0.05025833 0.05176667 0.06086667 0.00910000 0.73740011 0.02372642 FALSE  
ENST00000492091 ENSG00000076003 HEK293_OSMI2_2hA HEK293_TMG_2hB MCM6 protein_coding processed_transcript 98.95511 67.10495 115.8365 7.661746 1.944085 0.7875089 22.056850 15.790214 24.774624 1.7365350 0.8602985 0.6495013 0.22519583 0.23583333 0.21406667 -0.02176667 0.51706675 0.02372642 FALSE  
MSTRG.19270.3 ENSG00000076003 HEK293_OSMI2_2hA HEK293_TMG_2hB MCM6 protein_coding   98.95511 67.10495 115.8365 7.661746 1.944085 0.7875089 29.517988 23.230428 31.129802 3.1963137 1.6078667 0.4221232 0.30532500 0.34496667 0.26846667 -0.07650000 0.10461094 0.02372642 FALSE  
MSTRG.19270.7 ENSG00000076003 HEK293_OSMI2_2hA HEK293_TMG_2hB MCM6 protein_coding   98.95511 67.10495 115.8365 7.661746 1.944085 0.7875089 39.740966 23.974206 49.581331 2.7406427 1.2613399 1.0480033 0.39488333 0.35793333 0.42813333 0.07020000 0.03269126 0.02372642 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000076003 E001 73.227377 0.0085980674 9.739620e-02 1.865023e-01 2 135839626 135840416 791 - 1.911 1.819 -0.310
ENSG00000076003 E002 17.848526 0.0010387187 3.009272e-03 1.029336e-02 2 135840417 135840442 26 - 1.370 1.136 -0.826
ENSG00000076003 E003 33.805536 0.0043173060 4.430979e-03 1.434712e-02 2 135840443 135840465 23 - 1.447 1.653 0.705
ENSG00000076003 E004 43.150585 0.0039904239 1.347412e-03 5.134323e-03 2 135840466 135840482 17 - 1.547 1.757 0.714
ENSG00000076003 E005 165.758000 0.0012804591 6.201095e-23 5.456474e-21 2 135840483 135840520 38 - 2.047 2.379 1.110
ENSG00000076003 E006 1172.457301 0.0028169226 2.804301e-23 2.560321e-21 2 135840521 135840951 431 - 2.928 3.196 0.893
ENSG00000076003 E007 416.611773 0.0014088735 2.500033e-22 2.067323e-20 2 135844545 135844607 63 - 2.491 2.746 0.846
ENSG00000076003 E008 545.261034 0.0021540679 1.097578e-05 7.224770e-05 2 135844608 135844681 74 - 2.677 2.803 0.420
ENSG00000076003 E009 342.971762 0.0010540497 2.565092e-01 3.934704e-01 2 135844682 135844684 3 - 2.521 2.560 0.131
ENSG00000076003 E010 734.161047 0.0006973010 2.944567e-06 2.207167e-05 2 135846237 135846392 156 - 2.824 2.917 0.308
ENSG00000076003 E011 384.897120 0.0001693301 7.669955e-07 6.532760e-06 2 135848053 135848080 28 - 2.541 2.645 0.349
ENSG00000076003 E012 533.423491 0.0001051051 4.007310e-08 4.406877e-07 2 135848081 135848155 75 - 2.685 2.783 0.327
ENSG00000076003 E013 491.352450 0.0002228266 1.302836e-04 6.600836e-04 2 135848156 135848188 33 - 2.660 2.738 0.260
ENSG00000076003 E014 801.552438 0.0006646936 9.617575e-02 1.846356e-01 2 135851402 135851563 162 - 2.889 2.926 0.125
ENSG00000076003 E015 1.842481 0.0083746661 5.890612e-01 7.121707e-01 2 135851564 135851945 382 - 0.497 0.412 -0.433
ENSG00000076003 E016 681.626232 0.0005741216 4.875125e-01 6.251877e-01 2 135852787 135852915 129 - 2.837 2.833 -0.013
ENSG00000076003 E017 10.951870 0.0221342417 5.239637e-02 1.134283e-01 2 135856580 135856695 116 - 0.955 1.193 0.865
ENSG00000076003 E018 647.491865 0.0002174094 5.011771e-01 6.373349e-01 2 135856728 135856883 156 - 2.813 2.814 0.002
ENSG00000076003 E019 562.133948 0.0007198731 3.232488e-02 7.648504e-02 2 135857897 135858004 108 - 2.767 2.736 -0.104
ENSG00000076003 E020 613.317347 0.0001451636 1.093605e-02 3.100805e-02 2 135859301 135859442 142 - 2.803 2.777 -0.085
ENSG00000076003 E021 668.977493 0.0010695467 2.292663e-03 8.127627e-03 2 135862607 135862748 142 - 2.851 2.795 -0.184
ENSG00000076003 E022 701.064662 0.0007329672 4.164358e-11 7.829745e-10 2 135865013 135865163 151 - 2.895 2.781 -0.379
ENSG00000076003 E023 619.068216 0.0001305900 2.408624e-19 1.432152e-17 2 135866132 135866277 146 - 2.846 2.723 -0.410
ENSG00000076003 E024 603.378828 0.0004766270 8.112843e-13 2.021776e-11 2 135866563 135866728 166 - 2.832 2.714 -0.392
ENSG00000076003 E025 744.842634 0.0024282170 3.822673e-10 6.119087e-09 2 135868611 135868860 250 - 2.938 2.775 -0.545
ENSG00000076003 E026 521.672647 0.0004960541 4.513287e-28 6.414318e-26 2 135870251 135870361 111 - 2.798 2.598 -0.665
ENSG00000076003 E027 519.225796 0.0018716357 3.258471e-16 1.315099e-14 2 135872697 135872843 147 - 2.798 2.588 -0.701
ENSG00000076003 E028 293.194298 0.0074487808 3.313344e-06 2.457629e-05 2 135876259 135876528 270 - 2.554 2.330 -0.747