ENSG00000075975

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000170447 ENSG00000075975 HEK293_OSMI2_2hA HEK293_TMG_2hB MKRN2 protein_coding protein_coding 30.60622 26.60401 34.02188 2.343933 0.6905663 0.354701 26.138356 21.65111 29.738158 2.6898268 0.1762218 0.4576935 0.8482708 0.8088333 0.8745667 0.06573333 0.25296362 4.961463e-07 FALSE  
ENST00000411987 ENSG00000075975 HEK293_OSMI2_2hA HEK293_TMG_2hB MKRN2 protein_coding protein_coding 30.60622 26.60401 34.02188 2.343933 0.6905663 0.354701 2.271283 3.02353 1.544612 0.4565864 0.2709189 -0.9644436 0.0751750 0.1180667 0.0451000 -0.07296667 0.03371695 4.961463e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000075975 E001 2.6238794 0.0056547655 1.488743e-02 4.023585e-02 3 12557057 12557065 9 + 0.712 0.316 -1.954
ENSG00000075975 E002 10.6131389 0.0075120274 9.481968e-04 3.781510e-03 3 12557066 12557080 15 + 1.207 0.850 -1.316
ENSG00000075975 E003 13.5648509 0.0022567023 5.941386e-04 2.512202e-03 3 12557081 12557086 6 + 1.294 0.981 -1.125
ENSG00000075975 E004 14.5580528 0.0026964765 4.854172e-03 1.552553e-02 3 12557087 12557089 3 + 1.301 1.055 -0.875
ENSG00000075975 E005 65.2529926 0.0010024076 6.541984e-05 3.579894e-04 3 12557090 12557127 38 + 1.899 1.728 -0.577
ENSG00000075975 E006 110.3259895 0.0014452530 6.651210e-07 5.738725e-06 3 12557128 12557176 49 + 2.128 1.948 -0.601
ENSG00000075975 E007 0.5159433 0.2509680937 7.486017e-01 8.357870e-01 3 12557269 12557449 181 + 0.202 0.135 -0.707
ENSG00000075975 E008 0.6955713 0.0179399359 8.721157e-01 9.217576e-01 3 12557450 12557525 76 + 0.202 0.234 0.270
ENSG00000075975 E009 1.0329427 0.0203680579 6.449014e-02 1.342003e-01 3 12557526 12557876 351 + 0.113 0.445 2.589
ENSG00000075975 E010 181.5517634 0.0003018542 1.004165e-08 1.237308e-07 3 12568875 12568997 123 + 2.331 2.191 -0.469
ENSG00000075975 E011 100.4118398 0.0017766030 2.132441e-03 7.635027e-03 3 12568998 12569003 6 + 2.064 1.955 -0.364
ENSG00000075975 E012 2.6131806 0.0071035389 6.822542e-01 7.857205e-01 3 12569004 12570070 1067 + 0.598 0.544 -0.249
ENSG00000075975 E013 260.4515862 0.0001664146 2.163146e-03 7.729915e-03 3 12570071 12570252 182 + 2.448 2.394 -0.180
ENSG00000075975 E014 0.2214452 0.0437602076 4.138963e-01   3 12570253 12570324 72 + 0.000 0.133 10.456
ENSG00000075975 E015 0.1515154 0.0428378678 5.758002e-01   3 12570325 12570484 160 + 0.113 0.000 -11.003
ENSG00000075975 E016 0.2987644 0.0293881607 2.526605e-01   3 12570485 12570583 99 + 0.202 0.000 -12.187
ENSG00000075975 E017 0.1515154 0.0428378678 5.758002e-01   3 12570584 12570832 249 + 0.113 0.000 -11.003
ENSG00000075975 E018 126.7123258 0.0002755010 9.360571e-01 9.637989e-01 3 12572069 12572109 41 + 2.104 2.119 0.051
ENSG00000075975 E019 227.7662070 0.0002715798 3.158986e-01 4.586747e-01 3 12572110 12572274 165 + 2.369 2.357 -0.039
ENSG00000075975 E020 230.3093605 0.0002501316 1.276975e-01 2.309534e-01 3 12572275 12572373 99 + 2.381 2.358 -0.078
ENSG00000075975 E021 425.8498136 0.0001343898 4.610483e-06 3.309120e-05 3 12574792 12575006 215 + 2.666 2.602 -0.215
ENSG00000075975 E022 5.4447978 0.0521141811 7.864859e-01 8.632726e-01 3 12575007 12576610 1604 + 0.822 0.782 -0.156
ENSG00000075975 E023 0.1472490 0.0431451810 5.759407e-01   3 12576611 12576630 20 + 0.113 0.000 -10.999
ENSG00000075975 E024 358.2245301 0.0001545935 7.150312e-02 1.458352e-01 3 12576631 12576741 111 + 2.571 2.550 -0.069
ENSG00000075975 E025 13.6509210 0.0013399000 1.972786e-03 7.141407e-03 3 12581367 12581807 441 + 0.996 1.291 1.061
ENSG00000075975 E026 347.5402250 0.0001585094 2.466501e-01 3.820228e-01 3 12581808 12581952 145 + 2.530 2.564 0.114
ENSG00000075975 E027 1.1395084 0.0117242730 3.513503e-01 4.955683e-01 3 12581953 12582115 163 + 0.395 0.234 -1.053
ENSG00000075975 E028 387.3351780 0.0001517339 3.939716e-05 2.274539e-04 3 12582116 12582342 227 + 2.549 2.634 0.284
ENSG00000075975 E029 1021.2788729 0.0006581694 1.798678e-19 1.083479e-17 3 12582343 12583787 1445 + 2.942 3.074 0.438
ENSG00000075975 E030 58.7079943 0.0004866250 5.902311e-01 7.131219e-01 3 12583788 12586208 2421 + 1.785 1.772 -0.042