ENSG00000075856

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000228284 ENSG00000075856 HEK293_OSMI2_2hA HEK293_TMG_2hB SART3 protein_coding protein_coding 38.31648 29.71228 41.87835 1.679227 1.468201 0.4950043 9.578238 6.8193031 12.4587049 1.3273007 1.0351311 0.8685014 0.24327917 0.2262667 0.298366667 0.07210000 4.153208e-01 1.510848e-26 FALSE TRUE
ENST00000546815 ENSG00000075856 HEK293_OSMI2_2hA HEK293_TMG_2hB SART3 protein_coding protein_coding 38.31648 29.71228 41.87835 1.679227 1.468201 0.4950043 14.442968 15.0259315 14.0010176 1.3673390 1.1178689 -0.1018525 0.39164167 0.5060000 0.335866667 -0.17013333 3.962664e-02 1.510848e-26 FALSE TRUE
ENST00000548077 ENSG00000075856 HEK293_OSMI2_2hA HEK293_TMG_2hB SART3 protein_coding retained_intron 38.31648 29.71228 41.87835 1.679227 1.468201 0.4950043 2.022881 0.3646907 2.5299929 0.3646907 0.7194388 2.7610523 0.05050833 0.0137000 0.059566667 0.04586667 1.328950e-01 1.510848e-26 FALSE FALSE
ENST00000550322 ENSG00000075856 HEK293_OSMI2_2hA HEK293_TMG_2hB SART3 protein_coding protein_coding 38.31648 29.71228 41.87835 1.679227 1.468201 0.4950043 2.198426 0.0000000 3.0166114 0.0000000 0.3063604 8.2415597 0.04817917 0.0000000 0.071800000 0.07180000 1.510848e-26 1.510848e-26 FALSE FALSE
ENST00000651280 ENSG00000075856 HEK293_OSMI2_2hA HEK293_TMG_2hB SART3 protein_coding nonsense_mediated_decay 38.31648 29.71228 41.87835 1.679227 1.468201 0.4950043 2.670790 3.7784352 0.1265901 0.3439456 0.1265901 -4.7936768 0.07726667 0.1273000 0.002833333 -0.12446667 7.237004e-04 1.510848e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000075856 E001 82.3323674 0.0057300052 8.204911e-03 2.430376e-02 12 108522214 108522589 376 - 1.832 1.991 0.533
ENSG00000075856 E002 115.6170353 0.0141922721 5.622517e-03 1.761105e-02 12 108522590 108522703 114 - 1.949 2.149 0.671
ENSG00000075856 E003 77.5456847 0.0221678071 7.404526e-03 2.227036e-02 12 108522704 108522707 4 - 1.752 1.990 0.802
ENSG00000075856 E004 773.2752261 0.0047557461 2.737100e-08 3.105374e-07 12 108522708 108523411 704 - 2.771 2.968 0.656
ENSG00000075856 E005 354.4541505 0.0001774797 2.386337e-11 4.676090e-10 12 108523412 108523634 223 - 2.469 2.613 0.478
ENSG00000075856 E006 14.8845489 0.0012844883 1.162348e-01 2.145960e-01 12 108523869 108524315 447 - 1.109 1.260 0.539
ENSG00000075856 E007 324.5478817 0.0001804163 8.182226e-04 3.324964e-03 12 108524316 108524506 191 - 2.468 2.550 0.271
ENSG00000075856 E008 304.0900871 0.0015532489 3.807766e-01 5.250680e-01 12 108525457 108525609 153 - 2.465 2.504 0.128
ENSG00000075856 E009 514.7203251 0.0001889562 1.199680e-03 4.639322e-03 12 108526099 108526553 455 - 2.677 2.744 0.222
ENSG00000075856 E010 214.7864794 0.0002553865 1.609301e-02 4.294410e-02 12 108530142 108530209 68 - 2.293 2.366 0.246
ENSG00000075856 E011 146.8249787 0.0019643427 7.064520e-01 8.045980e-01 12 108530210 108530222 13 - 2.156 2.182 0.088
ENSG00000075856 E012 235.5993840 0.0023149485 9.457893e-01 9.699721e-01 12 108530223 108530310 88 - 2.368 2.377 0.029
ENSG00000075856 E013 151.4372991 0.0045240446 7.513561e-01 8.378292e-01 12 108531204 108531223 20 - 2.184 2.180 -0.012
ENSG00000075856 E014 197.2002485 0.0019774192 3.722725e-01 5.167232e-01 12 108531224 108531280 57 - 2.274 2.315 0.136
ENSG00000075856 E015 4.8874852 0.0097039591 9.324072e-06 6.240655e-05 12 108531364 108532221 858 - 1.012 0.366 -2.814
ENSG00000075856 E016 219.8877185 0.0007686202 7.931990e-01 8.677803e-01 12 108532222 108532334 113 - 2.333 2.353 0.067
ENSG00000075856 E017 9.3422797 0.0018571780 1.251491e-08 1.515832e-07 12 108532335 108532617 283 - 1.247 0.600 -2.483
ENSG00000075856 E018 227.8237585 0.0001950870 8.805852e-01 9.274092e-01 12 108535359 108535468 110 - 2.352 2.369 0.059
ENSG00000075856 E019 2.8160912 0.0056059208 1.594528e-01 2.743948e-01 12 108535469 108535573 105 - 0.685 0.475 -0.953
ENSG00000075856 E020 207.1897720 0.0002354443 1.354993e-01 2.418133e-01 12 108536514 108536572 59 - 2.333 2.310 -0.077
ENSG00000075856 E021 228.6723373 0.0036464810 2.972972e-01 4.386181e-01 12 108536708 108536785 78 - 2.375 2.350 -0.084
ENSG00000075856 E022 3.7319538 0.0042372565 4.521664e-04 1.975316e-03 12 108537106 108537487 382 - 0.888 0.366 -2.346
ENSG00000075856 E023 253.9417611 0.0009202225 1.104648e-03 4.318613e-03 12 108537488 108537595 108 - 2.445 2.375 -0.235
ENSG00000075856 E024 10.3523182 0.0017322550 7.733022e-06 5.269966e-05 12 108537596 108537695 100 - 1.239 0.776 -1.718
ENSG00000075856 E025 261.5342297 0.0001787610 5.036880e-03 1.603141e-02 12 108538065 108538203 139 - 2.445 2.397 -0.160
ENSG00000075856 E026 114.5720157 0.0007331155 5.074504e-02 1.104961e-01 12 108538934 108538944 11 - 2.092 2.038 -0.181
ENSG00000075856 E027 234.3675150 0.0020538534 2.702590e-02 6.605056e-02 12 108538945 108539089 145 - 2.401 2.344 -0.189
ENSG00000075856 E028 5.1580312 0.0119513553 1.224095e-02 3.411212e-02 12 108542770 108542851 82 - 0.939 0.599 -1.369
ENSG00000075856 E029 150.0293217 0.0026797811 6.498874e-02 1.350184e-01 12 108543028 108543068 41 - 2.209 2.150 -0.195
ENSG00000075856 E030 156.3999810 0.0006151516 9.688655e-04 3.851937e-03 12 108543069 108543111 43 - 2.241 2.155 -0.287
ENSG00000075856 E031 169.8154772 0.0024917002 1.225649e-03 4.727395e-03 12 108543112 108543152 41 - 2.284 2.178 -0.354
ENSG00000075856 E032 183.0510308 0.0007131492 8.800668e-05 4.656371e-04 12 108544427 108544478 52 - 2.314 2.215 -0.331
ENSG00000075856 E033 36.0289968 0.0005684452 1.551285e-05 9.866922e-05 12 108544479 108544532 54 - 1.682 1.444 -0.813
ENSG00000075856 E034 6.6118330 0.0025071009 6.239335e-04 2.620488e-03 12 108544533 108544944 412 - 1.051 0.634 -1.630
ENSG00000075856 E035 248.8166992 0.0003233658 2.828598e-08 3.199984e-07 12 108545139 108545288 150 - 2.456 2.339 -0.389
ENSG00000075856 E036 119.3619336 0.0032646695 4.137397e-03 1.352762e-02 12 108545289 108545323 35 - 2.135 2.025 -0.367
ENSG00000075856 E037 205.2495951 0.0027776034 7.012013e-03 2.125482e-02 12 108547887 108547991 105 - 2.357 2.276 -0.269
ENSG00000075856 E038 148.3608601 0.0155917489 1.409337e-01 2.493017e-01 12 108549088 108549136 49 - 2.214 2.139 -0.251
ENSG00000075856 E039 171.2943525 0.0072961009 1.865853e-01 3.094569e-01 12 108549137 108549214 78 - 2.262 2.213 -0.163
ENSG00000075856 E040 0.1482932 0.0412768655 4.844458e-01   12 108549300 108549328 29 - 0.000 0.124 8.171
ENSG00000075856 E041 0.0000000       12 108554068 108554198 131 -      
ENSG00000075856 E042 1.2136160 0.0122617098 2.548743e-01 3.916592e-01 12 108560217 108560842 626 - 0.215 0.424 1.370
ENSG00000075856 E043 349.9973869 0.0025040586 7.407194e-06 5.069253e-05 12 108560843 108561400 558 - 2.606 2.483 -0.410