ENSG00000075785

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265062 ENSG00000075785 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB7A protein_coding protein_coding 119.144 131.9529 126.9649 7.406288 2.860103 -0.0555891 103.484349 121.9311 104.56088 7.741145 3.3935779 -0.2217039 0.87070417 0.9233333 0.8232 -0.1001333 2.610014e-06 3.902565e-48 FALSE TRUE
ENST00000464496 ENSG00000075785 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB7A protein_coding protein_coding 119.144 131.9529 126.9649 7.406288 2.860103 -0.0555891 5.978175 0.0000 10.46049 0.000000 0.8684904 10.0321126 0.04820417 0.0000000 0.0827 0.0827000 3.902565e-48 3.902565e-48 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000075785 E001 0.0000000       3 128693669 128693792 124 +      
ENSG00000075785 E002 14.9004538 4.955777e-03 3.590428e-02 8.339821e-02 3 128726136 128726156 21 + 1.278 1.128 -0.531
ENSG00000075785 E003 26.1076257 7.696429e-04 2.195862e-02 5.558835e-02 3 128726157 128726162 6 + 1.490 1.379 -0.383
ENSG00000075785 E004 88.5385646 2.508285e-03 5.241315e-04 2.249805e-03 3 128726163 128726182 20 + 2.007 1.895 -0.378
ENSG00000075785 E005 113.8463719 1.657815e-03 2.007173e-03 7.248436e-03 3 128726183 128726192 10 + 2.098 2.022 -0.255
ENSG00000075785 E006 781.0410126 3.460541e-03 9.464774e-02 1.823526e-01 3 128726193 128726351 159 + 2.897 2.885 -0.038
ENSG00000075785 E007 537.0150315 4.716808e-03 7.852184e-02 1.571175e-01 3 128726352 128726359 8 + 2.741 2.718 -0.078
ENSG00000075785 E008 5.7905882 2.965910e-03 5.595852e-01 6.876802e-01 3 128788914 128789070 157 + 0.844 0.807 -0.143
ENSG00000075785 E009 0.0000000       3 128794552 128794783 232 +      
ENSG00000075785 E010 0.0000000       3 128794844 128795193 350 +      
ENSG00000075785 E011 0.2934659 2.880876e-02 9.155631e-01   3 128795243 128795358 116 + 0.125 0.120 -0.063
ENSG00000075785 E012 0.8867404 1.627758e-01 8.096346e-01 8.791460e-01 3 128795359 128795359 1 + 0.300 0.286 -0.096
ENSG00000075785 E013 852.2109622 4.504397e-04 1.903870e-05 1.186768e-04 3 128795360 128795420 61 + 2.943 2.919 -0.077
ENSG00000075785 E014 715.8708246 1.014188e-04 2.716434e-08 3.084329e-07 3 128797943 128797968 26 + 2.872 2.841 -0.105
ENSG00000075785 E015 967.1884107 8.110667e-05 2.760572e-07 2.573731e-06 3 128797969 128798036 68 + 2.995 2.979 -0.052
ENSG00000075785 E016 835.3863153 1.237142e-04 6.958562e-05 3.779902e-04 3 128798037 128798069 33 + 2.927 2.920 -0.023
ENSG00000075785 E017 3.4342561 5.081595e-03 4.475814e-01 5.889545e-01 3 128798070 128798425 356 + 0.698 0.621 -0.326
ENSG00000075785 E018 0.4482035 2.793870e-02 6.601635e-02 1.367276e-01 3 128799272 128799430 159 + 0.300 0.000 -11.214
ENSG00000075785 E019 0.4439371 2.156258e-02 6.505819e-02 1.351345e-01 3 128801992 128802169 178 + 0.300 0.000 -11.213
ENSG00000075785 E020 1032.7297989 8.710695e-05 2.250073e-02 5.672324e-02 3 128806372 128806449 78 + 3.004 3.022 0.061
ENSG00000075785 E021 1417.2444092 6.338880e-04 3.331050e-02 7.840975e-02 3 128806450 128806590 141 + 3.144 3.154 0.035
ENSG00000075785 E022 4.1791332 3.851527e-03 2.555091e-01 3.924083e-01 3 128806591 128806615 25 + 0.777 0.654 -0.509
ENSG00000075785 E023 9.5935781 3.681103e-02 2.518338e-02 6.225017e-02 3 128806616 128807542 927 + 1.145 0.872 -1.006
ENSG00000075785 E024 812.0267697 9.863126e-05 4.341904e-04 1.906150e-03 3 128807543 128807554 12 + 2.910 2.909 -0.004
ENSG00000075785 E025 1020.2990852 2.971607e-04 4.718920e-05 2.675081e-04 3 128807555 128807617 63 + 3.014 3.002 -0.038
ENSG00000075785 E026 875.3540495 3.516682e-04 1.806085e-02 4.726157e-02 3 128807618 128807671 54 + 2.936 2.945 0.028
ENSG00000075785 E027 3.0249501 2.453844e-02 4.870150e-01 6.247192e-01 3 128811146 128811257 112 + 0.636 0.552 -0.376
ENSG00000075785 E028 4558.6088177 2.292983e-03 2.650065e-11 5.149727e-10 3 128813327 128814798 1472 + 3.562 3.719 0.523
ENSG00000075785 E029 32.6089103 1.990076e-02 5.845407e-01 7.084379e-01 3 128823718 128825942 2225 + 1.472 1.556 0.287