ENSG00000075568

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000186436 ENSG00000075568 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM131 protein_coding protein_coding 13.97358 8.086018 19.32942 1.109572 0.3741179 1.25626 11.023900 7.10072978 13.660787 0.80942215 0.07889794 0.9430268 0.7995125 0.8848667 0.70736667 -0.17750000 0.0006160989 0.0006160989 FALSE TRUE
ENST00000480724 ENSG00000075568 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM131 protein_coding retained_intron 13.97358 8.086018 19.32942 1.109572 0.3741179 1.25626 1.005111 0.09811152 1.599989 0.05823407 0.27746139 3.8964589 0.0646500 0.0124000 0.08316667 0.07076667 0.0027456846 0.0006160989 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000075568 E001 0.0000000       2 97756333 97756335 3 -      
ENSG00000075568 E002 273.4319960 0.0125763138 4.194201e-15 1.459014e-13 2 97756336 97756906 571 - 2.180 2.661 1.606
ENSG00000075568 E003 81.4034139 0.0132680016 4.893371e-07 4.334367e-06 2 97756907 97756943 37 - 1.723 2.099 1.263
ENSG00000075568 E004 58.7600145 0.0161994060 1.709470e-06 1.349842e-05 2 97756944 97756950 7 - 1.569 1.970 1.358
ENSG00000075568 E005 152.3668810 0.0181752904 1.271041e-07 1.265344e-06 2 97756951 97757104 154 - 1.970 2.382 1.379
ENSG00000075568 E006 206.8785434 0.0053540910 2.105937e-09 2.936361e-08 2 97757105 97757383 279 - 2.173 2.459 0.953
ENSG00000075568 E007 65.1142561 0.0003862109 1.629083e-06 1.291912e-05 2 97758893 97758895 3 - 1.695 1.937 0.818
ENSG00000075568 E008 159.4384268 0.0032623935 1.263260e-09 1.836550e-08 2 97758896 97759050 155 - 2.067 2.335 0.897
ENSG00000075568 E009 55.9962099 0.0072872508 1.637058e-04 8.079950e-04 2 97759051 97759053 3 - 1.617 1.883 0.903
ENSG00000075568 E010 2.5336843 0.0073046497 2.040440e-01 3.312383e-01 2 97759054 97759651 598 - 0.449 0.675 1.042
ENSG00000075568 E011 83.6546555 0.0097413613 3.324086e-03 1.121768e-02 2 97759652 97759682 31 - 1.819 2.030 0.710
ENSG00000075568 E012 101.7578938 0.0030292743 6.065043e-03 1.878092e-02 2 97759683 97759749 67 - 1.930 2.082 0.510
ENSG00000075568 E013 9.4577854 0.0071047105 4.565203e-01 5.969396e-01 2 97759750 97760592 843 - 1.031 0.973 -0.216
ENSG00000075568 E014 106.4210337 0.0004797318 1.649845e-03 6.120551e-03 2 97760593 97760689 97 - 1.954 2.097 0.480
ENSG00000075568 E015 1.5468121 0.0095536258 7.785754e-01 8.575285e-01 2 97760690 97760792 103 - 0.413 0.380 -0.180
ENSG00000075568 E016 106.7736289 0.0009089330 2.165799e-02 5.496460e-02 2 97760793 97760914 122 - 1.968 2.084 0.389
ENSG00000075568 E017 1.5584534 0.0104275224 3.276902e-01 4.711663e-01 2 97760915 97762034 1120 - 0.449 0.287 -0.957
ENSG00000075568 E018 101.9259172 0.0002964504 5.487322e-05 3.060490e-04 2 97762035 97762200 166 - 1.918 2.093 0.587
ENSG00000075568 E019 8.1384075 0.0022221353 9.564860e-01 9.767309e-01 2 97762201 97765317 3117 - 0.940 0.973 0.125
ENSG00000075568 E020 110.9630065 0.0002742122 8.288680e-05 4.417187e-04 2 97766114 97766263 150 - 1.959 2.125 0.556
ENSG00000075568 E021 103.2487212 0.0002786814 1.129963e-04 5.816473e-04 2 97766478 97766602 125 - 1.929 2.096 0.562
ENSG00000075568 E022 105.2728837 0.0002793118 2.234266e-02 5.639005e-02 2 97772297 97772424 128 - 1.963 2.075 0.374
ENSG00000075568 E023 120.6504126 0.0011551965 7.539456e-01 8.397035e-01 2 97775843 97776018 176 - 2.050 2.092 0.143
ENSG00000075568 E024 194.8504082 0.0002265165 3.149611e-01 4.577099e-01 2 97792386 97792854 469 - 2.250 2.307 0.192
ENSG00000075568 E025 112.0561956 0.0020310007 1.073161e-03 4.211785e-03 2 97792855 97792984 130 - 2.071 1.968 -0.346
ENSG00000075568 E026 4.3704687 0.0036734331 1.812408e-02 4.739530e-02 2 97793290 97793394 105 - 0.809 0.458 -1.541
ENSG00000075568 E027 121.1112025 0.0082812147 1.703236e-01 2.885929e-01 2 97793395 97793553 159 - 2.080 2.046 -0.113
ENSG00000075568 E028 105.1897957 0.0058494143 5.998374e-01 7.211685e-01 2 97794930 97795115 186 - 2.002 2.014 0.039
ENSG00000075568 E029 96.2124506 0.0050323647 2.117745e-02 5.397193e-02 2 97796218 97796404 187 - 1.996 1.915 -0.274
ENSG00000075568 E030 72.3374672 0.0008604796 2.480918e-02 6.148163e-02 2 97796844 97796986 143 - 1.872 1.801 -0.240
ENSG00000075568 E031 81.9423986 0.0043026642 3.061859e-01 4.483545e-01 2 97797365 97797516 152 - 1.908 1.887 -0.071
ENSG00000075568 E032 64.7216930 0.0070811377 5.473650e-02 1.175366e-01 2 97801895 97801961 67 - 1.828 1.742 -0.292
ENSG00000075568 E033 74.0613153 0.0050489301 5.606895e-03 1.757027e-02 2 97802428 97802537 110 - 1.895 1.775 -0.405
ENSG00000075568 E034 71.8240463 0.0003639285 1.119222e-03 4.367765e-03 2 97802652 97802790 139 - 1.882 1.767 -0.389
ENSG00000075568 E035 64.7741238 0.0041593256 1.384738e-03 5.256994e-03 2 97805088 97805205 118 - 1.850 1.701 -0.504
ENSG00000075568 E036 61.1007309 0.0027905550 2.651822e-08 3.017738e-07 2 97805376 97805451 76 - 1.862 1.579 -0.960
ENSG00000075568 E037 79.5737222 0.0011718864 1.105354e-09 1.625697e-08 2 97805551 97805703 153 - 1.965 1.712 -0.854
ENSG00000075568 E038 56.5546006 0.0371472807 1.030593e-02 2.952008e-02 2 97809688 97809774 87 - 1.811 1.595 -0.731
ENSG00000075568 E039 59.3142591 0.0117890481 1.315122e-04 6.654892e-04 2 97811128 97811232 105 - 1.839 1.593 -0.834
ENSG00000075568 E040 67.1403485 0.0164258759 1.784763e-03 6.550516e-03 2 97812421 97812555 135 - 1.881 1.679 -0.685
ENSG00000075568 E041 57.9002532 0.0090233629 5.134561e-04 2.209890e-03 2 97812639 97812749 111 - 1.817 1.613 -0.690
ENSG00000075568 E042 80.3467887 0.0132378861 1.815628e-04 8.846844e-04 2 97813971 97814141 171 - 1.963 1.737 -0.758
ENSG00000075568 E043 73.0966383 0.0330750054 5.547918e-03 1.741251e-02 2 97814235 97814348 114 - 1.921 1.701 -0.744
ENSG00000075568 E044 43.8672021 0.0335972555 1.066343e-02 3.036535e-02 2 97814349 97814388 40 - 1.703 1.485 -0.741
ENSG00000075568 E045 63.5190120 0.0068314365 9.320615e-04 3.726495e-03 2 97815199 97815307 109 - 1.846 1.674 -0.581
ENSG00000075568 E046 64.6168244 0.0003893031 3.455818e-07 3.157589e-06 2 97818613 97818721 109 - 1.865 1.648 -0.734
ENSG00000075568 E047 51.6022645 0.0004534485 6.425892e-08 6.774812e-07 2 97833365 97833426 62 - 1.783 1.516 -0.908
ENSG00000075568 E048 47.4899502 0.0084406674 5.442919e-07 4.779793e-06 2 97834621 97834677 57 - 1.766 1.428 -1.155
ENSG00000075568 E049 66.7588816 0.0076426407 3.749892e-08 4.143758e-07 2 97834775 97834925 151 - 1.909 1.581 -1.109
ENSG00000075568 E050 45.4357181 0.0017678315 3.297701e-15 1.165559e-13 2 97837077 97837157 81 - 1.776 1.284 -1.687
ENSG00000075568 E051 43.7943071 0.0007054779 1.411028e-15 5.231533e-14 2 97841815 97841937 123 - 1.761 1.273 -1.674
ENSG00000075568 E052 37.3290175 0.0087339582 8.562733e-11 1.529208e-09 2 97844145 97844261 117 - 1.698 1.177 -1.802
ENSG00000075568 E053 52.4965168 0.0013871807 2.759218e-21 2.038711e-19 2 97859304 97859427 124 - 1.847 1.274 -1.965
ENSG00000075568 E054 0.1515154 0.0426657036 9.368967e-01   2 97887732 97888051 320 - 0.089 0.001 -7.108
ENSG00000075568 E055 46.7390422 0.0660893385 7.095121e-06 4.878945e-05 2 97888052 97888120 69 - 1.800 1.217 -2.005
ENSG00000075568 E056 0.0000000       2 97907115 97907246 132 -      
ENSG00000075568 E057 38.1007648 0.0904971124 1.184711e-04 6.068569e-04 2 97908658 97908698 41 - 1.711 1.150 -1.941
ENSG00000075568 E058 2.5161583 0.0390867572 4.902579e-02 1.074279e-01 2 97911621 97911671 51 - 0.644 0.286 -1.870
ENSG00000075568 E059 35.3907461 0.0031181459 5.072612e-17 2.257437e-15 2 97927426 97927487 62 - 1.691 1.035 -2.289
ENSG00000075568 E060 52.0644459 0.0004884629 4.783854e-23 4.254867e-21 2 97995476 97995948 473 - 1.846 1.262 -2.000