ENSG00000075539

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358350 ENSG00000075539 HEK293_OSMI2_2hA HEK293_TMG_2hB FRYL protein_coding protein_coding 2.757498 1.410691 4.071221 0.1781785 0.08795294 1.522408 0.22270087 0.15508481 0.3896907 0.01394522 0.07592367 1.27567678 0.08870417 0.11136667 0.09560000 -0.01576667 0.868335513 0.004943726 FALSE TRUE
ENST00000503339 ENSG00000075539 HEK293_OSMI2_2hA HEK293_TMG_2hB FRYL protein_coding retained_intron 2.757498 1.410691 4.071221 0.1781785 0.08795294 1.522408 0.19865199 0.26387861 0.1133186 0.15676823 0.02327961 -1.15114586 0.12555000 0.21176667 0.02773333 -0.18403333 0.433712671 0.004943726 FALSE TRUE
ENST00000505437 ENSG00000075539 HEK293_OSMI2_2hA HEK293_TMG_2hB FRYL protein_coding processed_transcript 2.757498 1.410691 4.071221 0.1781785 0.08795294 1.522408 0.08779457 0.00000000 0.4164186 0.00000000 0.26670050 5.41419842 0.02026667 0.00000000 0.10356667 0.10356667 0.405672786 0.004943726   FALSE
ENST00000507873 ENSG00000075539 HEK293_OSMI2_2hA HEK293_TMG_2hB FRYL protein_coding protein_coding 2.757498 1.410691 4.071221 0.1781785 0.08795294 1.522408 0.80625287 0.76411830 0.7745923 0.17641550 0.09925331 0.01938911 0.35588333 0.53553333 0.19146667 -0.34406667 0.004943726 0.004943726 FALSE TRUE
ENST00000511343 ENSG00000075539 HEK293_OSMI2_2hA HEK293_TMG_2hB FRYL protein_coding retained_intron 2.757498 1.410691 4.071221 0.1781785 0.08795294 1.522408 0.05645948 0.00000000 0.3428605 0.00000000 0.21424836 5.14102599 0.01454167 0.00000000 0.08390000 0.08390000 0.409796570 0.004943726   FALSE
ENST00000512810 ENSG00000075539 HEK293_OSMI2_2hA HEK293_TMG_2hB FRYL protein_coding processed_transcript 2.757498 1.410691 4.071221 0.1781785 0.08795294 1.522408 0.14308586 0.14656237 0.2599899 0.14656237 0.13448092 0.78616819 0.05040833 0.08306667 0.06266667 -0.02040000 0.883353719 0.004943726 FALSE TRUE
MSTRG.24841.3 ENSG00000075539 HEK293_OSMI2_2hA HEK293_TMG_2hB FRYL protein_coding   2.757498 1.410691 4.071221 0.1781785 0.08795294 1.522408 0.31851770 0.00000000 0.4425910 0.00000000 0.44259100 5.50013600 0.08735417 0.00000000 0.10986667 0.10986667 1.000000000 0.004943726 FALSE TRUE
MSTRG.24841.5 ENSG00000075539 HEK293_OSMI2_2hA HEK293_TMG_2hB FRYL protein_coding   2.757498 1.410691 4.071221 0.1781785 0.08795294 1.522408 0.12247740 0.00000000 0.3626599 0.00000000 0.25846799 5.21978755 0.04537917 0.00000000 0.08643333 0.08643333 0.434022315 0.004943726 FALSE TRUE
MSTRG.24841.7 ENSG00000075539 HEK293_OSMI2_2hA HEK293_TMG_2hB FRYL protein_coding   2.757498 1.410691 4.071221 0.1781785 0.08795294 1.522408 0.27483891 0.02044896 0.3832139 0.02044896 0.19161449 3.69084938 0.06773750 0.01160000 0.09380000 0.08220000 0.602965540 0.004943726 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000075539 E001 3.9156396 0.0540822387 7.200939e-04 2.970940e-03 4 48497357 48497502 146 - 0.420 0.986 2.410
ENSG00000075539 E002 4.3928862 0.0436177512 2.303504e-04 1.093110e-03 4 48497503 48497540 38 - 0.449 1.035 2.439
ENSG00000075539 E003 3.2567018 0.0371590407 1.812448e-03 6.638621e-03 4 48497541 48497566 26 - 0.389 0.901 2.263
ENSG00000075539 E004 18.2903384 0.0206797413 3.095619e-08 3.472824e-07 4 48497567 48497836 270 - 1.003 1.568 1.989
ENSG00000075539 E005 29.5791948 0.0017053086 1.033804e-15 3.894435e-14 4 48497837 48498315 479 - 1.220 1.747 1.815
ENSG00000075539 E006 18.3799541 0.0089108528 1.615493e-08 1.915928e-07 4 48498316 48498545 230 - 1.026 1.537 1.797
ENSG00000075539 E007 65.7994607 0.0004495376 5.148852e-16 2.020788e-14 4 48498546 48499253 708 - 1.640 1.999 1.212
ENSG00000075539 E008 36.6197057 0.0005527769 1.760938e-04 8.615372e-04 4 48499254 48499457 204 - 1.450 1.679 0.780
ENSG00000075539 E009 28.5412882 0.0008361941 4.091133e-03 1.339786e-02 4 48499458 48499680 223 - 1.357 1.557 0.687
ENSG00000075539 E010 18.6646394 0.0345863142 1.218905e-01 2.226065e-01 4 48500030 48500220 191 - 1.190 1.382 0.672
ENSG00000075539 E011 13.2542889 0.0088060005 7.692695e-04 3.147370e-03 4 48501623 48501733 111 - 0.987 1.331 1.230
ENSG00000075539 E012 0.3729606 0.0323192891 3.939640e-01 5.378733e-01 4 48502828 48502845 18 - 0.072 0.200 1.690
ENSG00000075539 E013 14.6643144 0.0012708085 7.742026e-02 1.553201e-01 4 48505547 48505615 69 - 1.101 1.267 0.593
ENSG00000075539 E014 1.6252773 0.0083477543 2.096530e-01 3.381505e-01 4 48505616 48506612 997 - 0.449 0.200 -1.636
ENSG00000075539 E015 15.9557751 0.0096703837 5.104314e-02 1.110266e-01 4 48510059 48510157 99 - 1.113 1.309 0.692
ENSG00000075539 E016 19.0078334 0.0010089522 4.329566e-03 1.406828e-02 4 48510835 48510984 150 - 1.170 1.407 0.832
ENSG00000075539 E017 22.2873920 0.0078365091 1.697293e-02 4.487559e-02 4 48512481 48512688 208 - 1.248 1.456 0.724
ENSG00000075539 E018 20.2653014 0.0076307706 2.458795e-01 3.811128e-01 4 48515028 48515208 181 - 1.248 1.355 0.375
ENSG00000075539 E019 12.0107907 0.0500899091 4.474436e-01 5.888283e-01 4 48515209 48515275 67 - 1.040 1.140 0.363
ENSG00000075539 E020 0.1515154 0.0431271874 1.000000e+00   4 48520524 48520685 162 - 0.072 0.000 -10.450
ENSG00000075539 E021 10.5324201 0.0026685103 5.686799e-02 1.212341e-01 4 48521048 48521093 46 - 0.953 1.159 0.750
ENSG00000075539 E022 17.6476404 0.0013832904 3.801604e-01 5.244396e-01 4 48521094 48521215 122 - 1.201 1.281 0.283
ENSG00000075539 E023 25.5090113 0.0007355755 5.707077e-01 6.971408e-01 4 48522901 48523104 204 - 1.384 1.343 -0.143
ENSG00000075539 E024 0.0000000       4 48523488 48523496 9 -      
ENSG00000075539 E025 18.9658338 0.0048508436 9.618498e-01 9.799279e-01 4 48527477 48527653 177 - 1.248 1.254 0.023
ENSG00000075539 E026 13.4517172 0.0017875014 5.376565e-01 6.691780e-01 4 48527971 48528045 75 - 1.094 1.159 0.233
ENSG00000075539 E027 17.8144087 0.0282124485 8.218797e-01 8.876852e-01 4 48528175 48528336 162 - 1.220 1.253 0.115
ENSG00000075539 E028 12.1728166 0.0111799863 6.524899e-01 7.631799e-01 4 48531156 48531300 145 - 1.088 1.038 -0.182
ENSG00000075539 E029 6.1241042 0.0031497029 6.259466e-01 7.419666e-01 4 48531301 48531353 53 - 0.821 0.754 -0.267
ENSG00000075539 E030 9.3845850 0.0030892450 8.721196e-01 9.217576e-01 4 48534545 48534685 141 - 0.979 0.963 -0.061
ENSG00000075539 E031 17.3450661 0.0010577899 7.456407e-01 8.336249e-01 4 48535657 48535827 171 - 1.220 1.193 -0.095
ENSG00000075539 E032 11.0754400 0.0060921751 4.298861e-01 5.725377e-01 4 48539971 48540068 98 - 1.055 0.963 -0.338
ENSG00000075539 E033 37.6548923 0.0005464075 6.485334e-03 1.988488e-02 4 48540353 48540960 608 - 1.580 1.397 -0.628
ENSG00000075539 E034 10.6963561 0.0017079234 2.599180e-03 9.062603e-03 4 48542027 48542121 95 - 1.101 0.706 -1.506
ENSG00000075539 E035 13.9102943 0.0023475027 7.680699e-01 8.501416e-01 4 48543807 48543997 191 - 1.131 1.103 -0.100
ENSG00000075539 E036 8.6122741 0.0019926909 7.269498e-01 8.198405e-01 4 48544783 48544904 122 - 0.944 0.904 -0.154
ENSG00000075539 E037 13.1350284 0.0050978651 3.780086e-01 5.223056e-01 4 48546067 48546268 202 - 1.131 1.038 -0.336
ENSG00000075539 E038 2.8891440 0.0059623273 8.057535e-01 8.765080e-01 4 48546269 48546271 3 - 0.549 0.593 0.200
ENSG00000075539 E039 0.6017953 0.1608134856 3.579383e-01 5.023472e-01 4 48546272 48546759 488 - 0.237 0.000 -12.085
ENSG00000075539 E040 0.1482932 0.0428259665 1.421409e-01   4 48547470 48547583 114 - 0.000 0.199 11.908
ENSG00000075539 E041 7.2186373 0.0194188373 8.160516e-01 8.835918e-01 4 48547584 48547654 71 - 0.866 0.902 0.136
ENSG00000075539 E042 7.9685374 0.0020519704 2.563031e-01 3.932539e-01 4 48547655 48547769 115 - 0.944 0.796 -0.570
ENSG00000075539 E043 6.4568329 0.0639912658 6.268971e-01 7.427703e-01 4 48548690 48548793 104 - 0.854 0.755 -0.390
ENSG00000075539 E044 9.4731271 0.0625610811 4.503078e-01 5.914205e-01 4 48549473 48549623 151 - 1.002 0.877 -0.470
ENSG00000075539 E045 0.0000000       4 48550502 48550591 90 -      
ENSG00000075539 E046 8.9782647 0.0223252866 4.186277e-02 9.447007e-02 4 48550592 48550704 113 - 1.018 0.707 -1.201
ENSG00000075539 E047 7.6559296 0.0051276192 1.847776e-01 3.071930e-01 4 48551494 48551578 85 - 0.935 0.754 -0.705
ENSG00000075539 E048 9.4443887 0.0018109938 1.394227e-01 2.472433e-01 4 48553215 48553383 169 - 1.018 0.835 -0.692
ENSG00000075539 E049 11.2524131 0.0015544104 3.405081e-01 4.844570e-01 4 48556978 48557118 141 - 1.068 0.963 -0.388
ENSG00000075539 E050 14.6768102 0.0013566749 2.208615e-03 7.868936e-03 4 48557453 48557712 260 - 1.215 0.871 -1.263
ENSG00000075539 E051 8.7834752 0.0020872348 2.479669e-02 6.145953e-02 4 48561468 48561636 169 - 1.011 0.706 -1.178
ENSG00000075539 E052 5.1472614 0.0300780726 1.106459e-01 2.064789e-01 4 48562889 48562988 100 - 0.809 0.524 -1.217
ENSG00000075539 E053 6.4884223 0.0026336091 4.430775e-02 9.894348e-02 4 48563948 48564102 155 - 0.897 0.593 -1.239
ENSG00000075539 E054 7.4869121 0.0026704439 3.648709e-02 8.450846e-02 4 48564933 48565043 111 - 0.953 0.653 -1.188
ENSG00000075539 E055 8.5358654 0.0020694621 1.279040e-02 3.542082e-02 4 48565531 48565691 161 - 1.003 0.654 -1.372
ENSG00000075539 E056 8.0292716 0.0092560628 2.651630e-02 6.498283e-02 4 48567248 48567420 173 - 0.979 0.654 -1.283
ENSG00000075539 E057 4.8446224 0.0032431594 1.091137e-01 2.042413e-01 4 48570827 48570918 92 - 0.784 0.523 -1.121
ENSG00000075539 E058 0.5870335 0.1305441640 3.498219e-01 4.940195e-01 4 48571690 48571897 208 - 0.237 0.000 -12.126
ENSG00000075539 E059 4.8664784 0.0104800430 5.708476e-01 6.972801e-01 4 48573186 48573243 58 - 0.743 0.654 -0.369
ENSG00000075539 E060 7.2493208 0.0024544473 2.192962e-02 5.552809e-02 4 48575117 48575221 105 - 0.935 0.593 -1.383
ENSG00000075539 E061 5.1456656 0.0038925653 5.282726e-03 1.670165e-02 4 48575222 48575241 20 - 0.833 0.336 -2.313
ENSG00000075539 E062 9.3728275 0.0025015957 5.038267e-06 3.583572e-05 4 48576030 48576222 193 - 1.082 0.336 -3.244
ENSG00000075539 E063 12.6630343 0.0019083940 4.774008e-05 2.703155e-04 4 48578973 48579241 269 - 1.186 0.653 -2.033
ENSG00000075539 E064 0.0000000       4 48580456 48580864 409 -      
ENSG00000075539 E065 6.6819849 0.0048807116 4.383913e-04 1.922187e-03 4 48580865 48580951 87 - 0.944 0.336 -2.740
ENSG00000075539 E066 9.6846186 0.0151130991 1.165390e-05 7.627203e-05 4 48581420 48581605 186 - 1.095 0.336 -3.293
ENSG00000075539 E067 10.9219566 0.0015752443 1.236872e-04 6.307280e-04 4 48582497 48582734 238 - 1.125 0.593 -2.079
ENSG00000075539 E068 7.9266977 0.0021702239 1.890747e-03 6.886141e-03 4 48586621 48586728 108 - 0.995 0.523 -1.928
ENSG00000075539 E069 9.0736062 0.0019973132 1.761323e-02 4.629952e-02 4 48589745 48589877 133 - 1.026 0.706 -1.234
ENSG00000075539 E070 10.8718301 0.0056893682 2.236906e-02 5.644584e-02 4 48590659 48590830 172 - 1.088 0.797 -1.097
ENSG00000075539 E071 5.0858498 0.0165265208 1.095982e-01 2.049781e-01 4 48593930 48594016 87 - 0.796 0.524 -1.167
ENSG00000075539 E072 5.0460058 0.0035888944 7.940408e-01 8.683839e-01 4 48595590 48595698 109 - 0.743 0.707 -0.149
ENSG00000075539 E073 5.4432972 0.0040993264 1.606765e-02 4.288607e-02 4 48595897 48596000 104 - 0.844 0.440 -1.773
ENSG00000075539 E074 0.9264823 0.0617410017 6.868814e-01 7.893219e-01 4 48598829 48598873 45 - 0.280 0.200 -0.635
ENSG00000075539 E075 4.5028447 0.0067647725 1.981188e-03 7.168662e-03 4 48602020 48602121 102 - 0.797 0.200 -3.170
ENSG00000075539 E076 4.8101420 0.0032392954 1.081929e-03 4.242156e-03 4 48603290 48603388 99 - 0.821 0.200 -3.267
ENSG00000075539 E077 4.8673863 0.0046735305 8.518624e-03 2.508398e-02 4 48605741 48605833 93 - 0.809 0.336 -2.219
ENSG00000075539 E078 0.0000000       4 48605834 48605846 13 -      
ENSG00000075539 E079 7.5146766 0.0022419875 1.153121e-04 5.923456e-04 4 48606438 48606606 169 - 0.987 0.336 -2.898
ENSG00000075539 E080 6.7104643 0.0026068963 3.759536e-05 2.181484e-04 4 48608987 48609067 81 - 0.953 0.200 -3.773
ENSG00000075539 E081 4.7874667 0.0054896947 1.150895e-03 4.474319e-03 4 48609744 48609823 80 - 0.821 0.200 -3.268
ENSG00000075539 E082 0.0000000       4 48617604 48619273 1670 -      
ENSG00000075539 E083 6.6277328 0.0025174599 2.876154e-03 9.900406e-03 4 48619274 48619370 97 - 0.926 0.440 -2.086
ENSG00000075539 E084 5.4389040 0.0029628822 1.581179e-02 4.231523e-02 4 48620639 48620656 18 - 0.844 0.440 -1.773
ENSG00000075539 E085 9.8268787 0.0017228257 6.601688e-04 2.752961e-03 4 48620657 48620778 122 - 1.075 0.593 -1.898
ENSG00000075539 E086 6.2420721 0.0026870926 5.524862e-03 1.735184e-02 4 48623126 48623179 54 - 0.897 0.440 -1.976
ENSG00000075539 E087 9.0195459 0.0019314481 7.780501e-05 4.176918e-04 4 48634291 48634417 127 - 1.055 0.440 -2.561
ENSG00000075539 E088 5.6142551 0.0030250454 2.319303e-04 1.099645e-03 4 48634418 48634490 73 - 0.887 0.200 -3.523
ENSG00000075539 E089 1.5961430 0.0457756254 2.795063e-01 4.192681e-01 4 48636850 48638188 1339 - 0.320 0.523 1.098
ENSG00000075539 E090 0.8877725 0.0172488229 6.036791e-01 7.244187e-01 4 48638189 48638563 375 - 0.237 0.336 0.684
ENSG00000075539 E091 0.1472490 0.0434546819 1.000000e+00   4 48645969 48646017 49 - 0.072 0.000 -10.449
ENSG00000075539 E092 0.0000000       4 48653714 48653917 204 -      
ENSG00000075539 E093 0.0000000       4 48680930 48681171 242 -      
ENSG00000075539 E094 7.3921912 0.0022469684 4.360790e-03 1.414984e-02 4 48684673 48684795 123 - 0.962 0.523 -1.805
ENSG00000075539 E095 7.9789852 0.0328616912 3.723992e-04 1.667374e-03 4 48710519 48710698 180 - 1.011 0.337 -2.978
ENSG00000075539 E096 0.0000000       4 48727431 48727491 61 -      
ENSG00000075539 E097 7.1917247 0.0464738261 1.951502e-04 9.430559e-04 4 48780078 48780322 245 - 0.979 0.200 -3.865