ENSG00000075420

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336824 ENSG00000075420 HEK293_OSMI2_2hA HEK293_TMG_2hB FNDC3B protein_coding protein_coding 3.030196 1.870613 4.922549 0.06490168 0.1712879 1.39113 0.2298705 0.167759912 0.5199605 0.167759912 0.2738937 1.5759548 0.08529583 0.08646667 0.1045667 0.0181000 7.821768e-01 1.413977e-06 FALSE TRUE
ENST00000415807 ENSG00000075420 HEK293_OSMI2_2hA HEK293_TMG_2hB FNDC3B protein_coding protein_coding 3.030196 1.870613 4.922549 0.06490168 0.1712879 1.39113 0.9414891 0.728633059 1.1782302 0.140568812 0.2478627 0.6858846 0.31785833 0.39573333 0.2424000 -0.1533333 4.512936e-01 1.413977e-06 FALSE TRUE
ENST00000416957 ENSG00000075420 HEK293_OSMI2_2hA HEK293_TMG_2hB FNDC3B protein_coding protein_coding 3.030196 1.870613 4.922549 0.06490168 0.1712879 1.39113 0.6970934 0.000000000 1.2157541 0.000000000 0.2617195 6.9375257 0.16620833 0.00000000 0.2473667 0.2473667 1.413977e-06 1.413977e-06 FALSE TRUE
ENST00000421757 ENSG00000075420 HEK293_OSMI2_2hA HEK293_TMG_2hB FNDC3B protein_coding protein_coding 3.030196 1.870613 4.922549 0.06490168 0.1712879 1.39113 0.7929083 0.543946915 0.9585917 0.275179617 0.4829307 0.8061409 0.30582917 0.29496667 0.1904667 -0.1045000 9.223826e-01 1.413977e-06   FALSE
ENST00000423424 ENSG00000075420 HEK293_OSMI2_2hA HEK293_TMG_2hB FNDC3B protein_coding protein_coding 3.030196 1.870613 4.922549 0.06490168 0.1712879 1.39113 0.1557224 0.412360574 0.4795177 0.412360574 0.4795177 0.2128859 0.06698333 0.21356667 0.1017000 -0.1118667 9.213089e-01 1.413977e-06   FALSE
MSTRG.24068.1 ENSG00000075420 HEK293_OSMI2_2hA HEK293_TMG_2hB FNDC3B protein_coding   3.030196 1.870613 4.922549 0.06490168 0.1712879 1.39113 0.1811700 0.004492064 0.5012910 0.004492064 0.2506825 5.1408097 0.04487917 0.00230000 0.0999000 0.0976000 4.192287e-01 1.413977e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000075420 E001 1.4361966 0.0096765512 7.473884e-01 8.349283e-01 3 172039578 172039627 50 + 0.356 0.337 -0.116
ENSG00000075420 E002 2.3981533 0.0088905659 5.391199e-01 6.704130e-01 3 172039628 172039658 31 + 0.502 0.440 -0.308
ENSG00000075420 E003 9.3964360 0.0368161138 8.528528e-01 9.088272e-01 3 172039659 172039771 113 + 0.953 0.994 0.151
ENSG00000075420 E004 0.1472490 0.0435006892 1.000000e+00   3 172040554 172040554 1 + 0.072 0.000 -10.238
ENSG00000075420 E005 1.0267042 0.0199430991 7.460014e-02 1.508960e-01 3 172040555 172040624 70 + 0.356 0.000 -12.862
ENSG00000075420 E006 0.0000000       3 172046913 172046947 35 +      
ENSG00000075420 E007 23.4423860 0.0011439546 9.655160e-01 9.823318e-01 3 172112452 172112590 139 + 1.321 1.397 0.266
ENSG00000075420 E008 0.0000000       3 172126973 172126973 1 +      
ENSG00000075420 E009 0.0000000       3 172126974 172127057 84 +      
ENSG00000075420 E010 20.5130884 0.0009505892 7.886304e-01 8.646896e-01 3 172133471 172133546 76 + 1.260 1.355 0.329
ENSG00000075420 E011 0.1515154 0.0431552503 1.000000e+00   3 172148535 172148570 36 + 0.072 0.000 -10.238
ENSG00000075420 E012 0.2987644 0.0270645965 6.538718e-01   3 172184245 172184383 139 + 0.134 0.000 -11.194
ENSG00000075420 E013 18.5317120 0.0121591736 8.154870e-05 4.353224e-04 3 172186712 172187298 587 + 1.081 1.512 1.511
ENSG00000075420 E014 10.6854032 0.0019196047 1.128676e-02 3.184611e-02 3 172226871 172226947 77 + 1.074 0.835 -0.895
ENSG00000075420 E015 0.0000000       3 172226948 172227263 316 +      
ENSG00000075420 E016 15.1746782 0.0014939329 4.771836e-02 1.051187e-01 3 172247533 172247776 244 + 1.190 1.062 -0.461
ENSG00000075420 E017 17.0341087 0.0013627086 3.395918e-01 4.835299e-01 3 172251260 172251541 282 + 1.210 1.194 -0.058
ENSG00000075420 E018 8.4167384 0.0021099359 4.258429e-01 5.687217e-01 3 172285926 172285984 59 + 0.935 0.904 -0.117
ENSG00000075420 E019 12.6107126 0.0014171433 1.322196e-01 2.371960e-01 3 172295363 172295514 152 + 1.106 1.015 -0.332
ENSG00000075420 E020 7.9625509 0.0024570115 3.592970e-04 1.616031e-03 3 172298728 172298787 60 + 0.995 0.524 -1.925
ENSG00000075420 E021 0.0000000       3 172306936 172307362 427 +      
ENSG00000075420 E022 13.6749807 0.0013598392 5.412448e-02 1.164679e-01 3 172307363 172307501 139 + 1.147 1.015 -0.479
ENSG00000075420 E023 9.9901586 0.0017940484 1.115687e-02 3.154256e-02 3 172310828 172310881 54 + 1.047 0.797 -0.947
ENSG00000075420 E024 0.2214452 0.0379743465 1.724223e-01   3 172310882 172310927 46 + 0.000 0.200 12.484
ENSG00000075420 E025 13.2688363 0.0014946186 3.819557e-02 8.771977e-02 3 172328952 172329073 122 + 1.142 0.990 -0.552
ENSG00000075420 E026 5.2393398 0.0033656138 2.047524e-01 3.320839e-01 3 172329074 172329076 3 + 0.783 0.654 -0.532
ENSG00000075420 E027 0.1451727 0.0441382590 1.000000e+00   3 172329077 172330540 1464 + 0.072 0.000 -10.238
ENSG00000075420 E028 18.4050416 0.0016788986 1.520291e-01 2.644446e-01 3 172330541 172330715 175 + 1.252 1.194 -0.204
ENSG00000075420 E029 14.6908723 0.0012681553 1.829532e-01 3.048850e-01 3 172333089 172333175 87 + 1.164 1.104 -0.216
ENSG00000075420 E030 17.2804127 0.0010627840 1.060611e-02 3.022497e-02 3 172334944 172335082 139 + 1.256 1.083 -0.616
ENSG00000075420 E031 0.0000000       3 172335083 172335814 732 +      
ENSG00000075420 E032 12.2526275 0.0015353799 9.907126e-02 1.890525e-01 3 172337330 172337401 72 + 1.100 0.990 -0.403
ENSG00000075420 E033 0.3030308 0.3668421450 7.788470e-01   3 172337402 172338324 923 + 0.135 0.000 -11.115
ENSG00000075420 E034 16.1833080 0.0018687767 3.964864e-01 5.402503e-01 3 172341113 172341231 119 + 1.185 1.177 -0.028
ENSG00000075420 E035 14.4200345 0.0051225110 2.416551e-01 3.761313e-01 3 172343011 172343116 106 + 1.153 1.103 -0.179
ENSG00000075420 E036 18.7969948 0.0028226325 1.521312e-02 4.097153e-02 3 172344086 172344258 173 + 1.281 1.124 -0.559
ENSG00000075420 E037 0.0000000       3 172345895 172346326 432 +      
ENSG00000075420 E038 15.8168415 0.0073229916 2.267885e-02 5.709099e-02 3 172346327 172346440 114 + 1.215 1.040 -0.627
ENSG00000075420 E039 17.3679175 0.0077136897 1.645070e-01 2.810395e-01 3 172347212 172347361 150 + 1.229 1.161 -0.240
ENSG00000075420 E040 23.0197949 0.0032311699 3.717874e-01 5.162648e-01 3 172352803 172353083 281 + 1.332 1.332 0.000
ENSG00000075420 E041 20.8530212 0.0008734063 5.848277e-02 1.240345e-01 3 172362633 172362845 213 + 1.313 1.225 -0.310
ENSG00000075420 E042 20.1788920 0.0009996787 8.046152e-02 1.602826e-01 3 172378270 172378436 167 + 1.301 1.225 -0.270
ENSG00000075420 E043 24.4491216 0.0008640233 2.411561e-01 3.755399e-01 3 172380966 172381093 128 + 1.360 1.343 -0.059
ENSG00000075420 E044 35.5938549 0.0005629592 6.803188e-01 7.842300e-01 3 172397164 172397492 329 + 1.485 1.584 0.342
ENSG00000075420 E045 149.3021362 0.0173236389 1.650267e-07 1.607560e-06 3 172397493 172401669 4177 + 1.994 2.361 1.228
ENSG00000075420 E046 0.8973375 0.0384544800 5.655411e-01 6.926248e-01 3 172402154 172402360 207 + 0.280 0.200 -0.636