ENSG00000075303

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341119 ENSG00000075303 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A40 protein_coding protein_coding 6.694104 2.020755 10.58445 0.4756189 0.27692 2.38322 3.1866705 1.45151255 4.8960052 0.21841943 0.10959378 1.7470865 0.55436250 0.76606667 0.46266667 -0.30340000 0.3073101113 0.0001902119 FALSE TRUE
ENST00000429674 ENSG00000075303 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A40 protein_coding nonsense_mediated_decay 6.694104 2.020755 10.58445 0.4756189 0.27692 2.38322 0.3430441 0.15586295 0.6202792 0.07797023 0.13074482 1.9259993 0.05255417 0.06483333 0.05873333 -0.00610000 0.8560536941 0.0001902119 TRUE TRUE
ENST00000470328 ENSG00000075303 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A40 protein_coding retained_intron 6.694104 2.020755 10.58445 0.4756189 0.27692 2.38322 0.4219917 0.06382387 0.6785222 0.04271138 0.04040649 3.2213438 0.06004583 0.02833333 0.06403333 0.03570000 0.2456422009 0.0001902119   FALSE
ENST00000496348 ENSG00000075303 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A40 protein_coding retained_intron 6.694104 2.020755 10.58445 0.4756189 0.27692 2.38322 0.2982219 0.09961541 0.1762885 0.09961541 0.02117400 0.7650879 0.07254167 0.03570000 0.01666667 -0.01903333 0.8851433794 0.0001902119   FALSE
MSTRG.30177.3 ENSG00000075303 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A40 protein_coding   6.694104 2.020755 10.58445 0.4756189 0.27692 2.38322 2.1380957 0.11478359 3.7478449 0.08185709 0.17373311 4.9124054 0.21253333 0.05143333 0.35420000 0.30276667 0.0001902119 0.0001902119 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000075303 E001 188.506168 0.0005319178 6.017734e-11 1.100002e-09 7 87833568 87836109 2542 - 2.166 2.336 0.569
ENSG00000075303 E002 3.717314 0.0378381193 2.224459e-02 5.618147e-02 7 87836110 87836110 1 - 0.498 0.869 1.573
ENSG00000075303 E003 14.563642 0.0247012427 2.713257e-01 4.100600e-01 7 87836111 87836167 57 - 1.094 1.215 0.431
ENSG00000075303 E004 27.094927 0.0006956498 7.481577e-01 8.354823e-01 7 87836168 87836248 81 - 1.378 1.403 0.089
ENSG00000075303 E005 29.701116 0.0007322643 9.662712e-01 9.828205e-01 7 87836249 87836296 48 - 1.426 1.424 -0.006
ENSG00000075303 E006 37.336224 0.0005946598 1.231028e-01 2.243764e-01 7 87836297 87836361 65 - 1.496 1.595 0.340
ENSG00000075303 E007 39.808591 0.0005549741 3.318973e-01 4.755336e-01 7 87836730 87836810 81 - 1.533 1.595 0.212
ENSG00000075303 E008 1.552111 0.0091549690 9.610347e-01 9.794613e-01 7 87836811 87837147 337 - 0.366 0.358 -0.050
ENSG00000075303 E009 37.989412 0.0006278340 8.105235e-02 1.611917e-01 7 87841633 87841714 82 - 1.498 1.609 0.379
ENSG00000075303 E010 2.150684 0.0077691022 9.445327e-01 9.691961e-01 7 87841715 87841931 217 - 0.450 0.465 0.074
ENSG00000075303 E011 4.008018 0.0046643371 5.937846e-02 1.255771e-01 7 87841932 87842041 110 - 0.711 0.358 -1.695
ENSG00000075303 E012 3.414857 0.0046083471 2.266564e-03 8.050250e-03 7 87842042 87842267 226 - 0.682 0.000 -11.874
ENSG00000075303 E013 46.883641 0.0005020752 6.743222e-02 1.390882e-01 7 87843754 87843863 110 - 1.639 1.526 -0.384
ENSG00000075303 E014 2.258294 0.0076096432 1.371743e-01 2.441494e-01 7 87843864 87843864 1 - 0.521 0.215 -1.858
ENSG00000075303 E015 60.626954 0.0005458878 6.025460e-03 1.867860e-02 7 87846949 87847122 174 - 1.754 1.602 -0.516
ENSG00000075303 E016 40.142912 0.0006069852 7.602056e-02 1.531446e-01 7 87847853 87847977 125 - 1.573 1.455 -0.406
ENSG00000075303 E017 31.056214 0.0006409862 1.036700e-02 2.966718e-02 7 87849881 87849948 68 - 1.479 1.277 -0.703
ENSG00000075303 E018 34.467351 0.0006096969 5.146815e-02 1.117611e-01 7 87854204 87854256 53 - 1.511 1.369 -0.491
ENSG00000075303 E019 32.085372 0.0029336105 1.490586e-02 4.027433e-02 7 87854257 87854310 54 - 1.491 1.291 -0.692
ENSG00000075303 E020 0.000000       7 87856291 87856291 1 -      
ENSG00000075303 E021 32.991437 0.0006846183 1.513119e-01 2.634559e-01 7 87856292 87856351 60 - 1.486 1.381 -0.364
ENSG00000075303 E022 1.194026 0.0149554783 5.604964e-01 6.884898e-01 7 87856352 87856389 38 - 0.334 0.215 -0.860
ENSG00000075303 E023 33.885187 0.0007063536 2.530305e-01 3.894977e-01 7 87858631 87858751 121 - 1.496 1.414 -0.281
ENSG00000075303 E024 2.736787 0.0056284501 2.892042e-01 4.298717e-01 7 87860072 87860169 98 - 0.562 0.358 -1.050
ENSG00000075303 E025 20.628323 0.0129681619 1.179751e-01 2.170284e-01 7 87860572 87860640 69 - 1.309 1.138 -0.605
ENSG00000075303 E026 27.640874 0.0008262446 2.540426e-01 3.906755e-01 7 87876096 87876360 265 - 1.409 1.319 -0.315