ENSG00000075275

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262738 ENSG00000075275 HEK293_OSMI2_2hA HEK293_TMG_2hB CELSR1 protein_coding protein_coding 7.312414 8.183002 5.692729 1.196471 0.5913149 -0.5227397 1.1792162 1.1457658 0.9201122 0.1210792 0.08628714 -0.3133725 0.16452083 0.14176667 0.16526667 0.0235000 7.694906e-01 5.673086e-07 FALSE TRUE
ENST00000473624 ENSG00000075275 HEK293_OSMI2_2hA HEK293_TMG_2hB CELSR1 protein_coding protein_coding 7.312414 8.183002 5.692729 1.196471 0.5913149 -0.5227397 2.0359377 3.7954802 0.6854794 0.7355404 0.12636668 -2.4519988 0.25529583 0.46513333 0.11856667 -0.3465667 5.673086e-07 5.673086e-07 FALSE TRUE
ENST00000674359 ENSG00000075275 HEK293_OSMI2_2hA HEK293_TMG_2hB CELSR1 protein_coding protein_coding 7.312414 8.183002 5.692729 1.196471 0.5913149 -0.5227397 0.5164559 0.5008899 0.3474730 0.1169522 0.16564158 -0.5151782 0.06967917 0.06016667 0.05666667 -0.0035000 9.463504e-01 5.673086e-07 FALSE TRUE
ENST00000674500 ENSG00000075275 HEK293_OSMI2_2hA HEK293_TMG_2hB CELSR1 protein_coding protein_coding 7.312414 8.183002 5.692729 1.196471 0.5913149 -0.5227397 2.9167743 2.2609093 3.2481333 0.4729357 0.14841854 0.5207755 0.42390000 0.27450000 0.57716667 0.3026667 3.840755e-04 5.673086e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000075275 E001 0.1515154 0.0430716308 4.277599e-01   22 46360834 46361173 340 - 0.128 0.000 -9.370
ENSG00000075275 E002 265.5156876 0.0073219845 8.815238e-12 1.853107e-10 22 46361174 46361985 812 - 2.202 2.530 1.096
ENSG00000075275 E003 292.8927117 0.0064576635 2.547267e-05 1.541501e-04 22 46361986 46363187 1202 - 2.334 2.535 0.669
ENSG00000075275 E004 21.4169761 0.0080535932 8.705039e-01 9.207095e-01 22 46363188 46363247 60 - 1.327 1.335 0.027
ENSG00000075275 E005 9.6012495 0.0185423988 7.502195e-01 8.369720e-01 22 46363248 46363995 748 - 1.039 1.011 -0.102
ENSG00000075275 E006 62.9741110 0.0085497532 5.429764e-01 6.736736e-01 22 46363996 46364251 256 - 1.755 1.819 0.215
ENSG00000075275 E007 34.2613468 0.0006267185 6.910888e-01 7.926375e-01 22 46364512 46364629 118 - 1.508 1.548 0.137
ENSG00000075275 E008 33.7227021 0.0006054581 6.278174e-01 7.435202e-01 22 46364630 46364736 107 - 1.499 1.544 0.156
ENSG00000075275 E009 0.0000000       22 46365225 46365230 6 -      
ENSG00000075275 E010 47.1071336 0.0004851830 1.437627e-01 2.531360e-01 22 46365231 46365380 150 - 1.610 1.703 0.315
ENSG00000075275 E011 0.9222279 0.0129760145 8.646619e-01 9.167615e-01 22 46365381 46365585 205 - 0.307 0.285 -0.153
ENSG00000075275 E012 42.8912681 0.0034170312 8.559405e-01 9.109443e-01 22 46365586 46365689 104 - 1.618 1.644 0.090
ENSG00000075275 E013 47.7054008 0.0005080736 9.032190e-01 9.424200e-01 22 46366386 46366480 95 - 1.668 1.678 0.034
ENSG00000075275 E014 0.0000000       22 46366481 46366549 69 -      
ENSG00000075275 E015 53.1921674 0.0012221117 6.556629e-01 7.655017e-01 22 46366993 46367118 126 - 1.725 1.719 -0.021
ENSG00000075275 E016 46.1956346 0.0005155666 2.168817e-01 3.466399e-01 22 46367729 46367855 127 - 1.614 1.695 0.274
ENSG00000075275 E017 0.8856816 0.0905629663 7.772466e-01 8.566402e-01 22 46368859 46369178 320 - 0.227 0.286 0.445
ENSG00000075275 E018 34.7310284 0.0006305429 2.281429e-01 3.602199e-01 22 46369179 46369258 80 - 1.489 1.577 0.302
ENSG00000075275 E019 40.9570063 0.0005443705 3.788939e-01 5.231889e-01 22 46369692 46369804 113 - 1.572 1.637 0.220
ENSG00000075275 E020 2.0951581 0.0124167623 3.691207e-01 5.135593e-01 22 46369805 46370237 433 - 0.375 0.541 0.852
ENSG00000075275 E021 26.4724768 0.0007432691 4.336902e-01 5.760935e-01 22 46372883 46372912 30 - 1.386 1.455 0.239
ENSG00000075275 E022 51.6521046 0.0021438529 8.740795e-01 9.230360e-01 22 46372913 46373057 145 - 1.708 1.717 0.029
ENSG00000075275 E023 3.8153311 0.1187289750 5.662358e-01 6.932472e-01 22 46373058 46374084 1027 - 0.736 0.618 -0.497
ENSG00000075275 E024 61.1530209 0.0004275623 3.269621e-01 4.704121e-01 22 46377061 46377261 201 - 1.797 1.769 -0.094
ENSG00000075275 E025 0.0000000       22 46377348 46377624 277 -      
ENSG00000075275 E026 40.5005626 0.0046614185 3.710560e-01 5.154645e-01 22 46378591 46378717 127 - 1.560 1.636 0.260
ENSG00000075275 E027 40.0414552 0.0005459712 7.552853e-01 8.406767e-01 22 46380788 46380955 168 - 1.599 1.598 -0.004
ENSG00000075275 E028 41.0420217 0.0050236658 6.679360e-01 7.750686e-01 22 46381846 46382050 205 - 1.614 1.608 -0.020
ENSG00000075275 E029 0.0000000       22 46384501 46384542 42 -      
ENSG00000075275 E030 33.7527736 0.0020952229 4.088715e-01 5.524848e-01 22 46384543 46384686 144 - 1.548 1.513 -0.118
ENSG00000075275 E031 42.1481877 0.0054589978 1.523415e-01 2.648811e-01 22 46386402 46386585 184 - 1.662 1.591 -0.243
ENSG00000075275 E032 45.9982379 0.0102533924 7.143186e-01 8.105605e-01 22 46389290 46389499 210 - 1.628 1.680 0.173
ENSG00000075275 E033 31.8639640 0.0008618885 5.782709e-01 7.034042e-01 22 46390392 46390486 95 - 1.469 1.521 0.177
ENSG00000075275 E034 5.6315565 0.0044550072 6.461883e-01 7.581662e-01 22 46390528 46390863 336 - 0.763 0.837 0.292
ENSG00000075275 E035 3.4329808 0.1412616743 4.310191e-01 5.736192e-01 22 46390864 46391033 170 - 0.531 0.720 0.824
ENSG00000075275 E036 1.5509622 0.3539336582 5.140248e-01 6.487791e-01 22 46391034 46391075 42 - 0.307 0.458 0.866
ENSG00000075275 E037 34.2108951 0.0006462518 4.981726e-01 6.346738e-01 22 46391186 46391287 102 - 1.499 1.556 0.195
ENSG00000075275 E038 44.1187959 0.0005162533 4.758314e-01 6.145136e-01 22 46391633 46391816 184 - 1.607 1.661 0.185
ENSG00000075275 E039 35.7647309 0.0042455909 5.732783e-01 6.992259e-01 22 46394142 46394262 121 - 1.556 1.540 -0.055
ENSG00000075275 E040 34.0024320 0.0235199066 7.969023e-01 8.704067e-01 22 46396605 46396746 142 - 1.489 1.556 0.232
ENSG00000075275 E041 46.6652599 0.0113300388 3.196570e-01 4.627592e-01 22 46397674 46397848 175 - 1.697 1.647 -0.167
ENSG00000075275 E042 41.7496342 0.0052517633 1.066349e-01 2.005876e-01 22 46398524 46398637 114 - 1.665 1.583 -0.279
ENSG00000075275 E043 31.6583233 0.0043607507 4.340342e-04 1.905552e-03 22 46399717 46399761 45 - 1.618 1.396 -0.762
ENSG00000075275 E044 43.9800097 0.0032775886 4.690793e-04 2.041838e-03 22 46399762 46399902 141 - 1.739 1.553 -0.632
ENSG00000075275 E045 0.0000000       22 46399903 46399926 24 -      
ENSG00000075275 E046 47.6080672 0.0028010592 1.082988e-02 3.075855e-02 22 46408996 46409162 167 - 1.747 1.622 -0.425
ENSG00000075275 E047 1.2835483 0.1191279155 4.131867e-01 5.567185e-01 22 46409163 46409276 114 - 0.434 0.286 -0.881
ENSG00000075275 E048 40.6983573 0.0327541176 2.514271e-01 3.876724e-01 22 46409755 46409880 126 - 1.668 1.573 -0.323
ENSG00000075275 E049 40.2243067 0.0117219780 9.604388e-01 9.790748e-01 22 46410398 46410561 164 - 1.599 1.614 0.051
ENSG00000075275 E050 36.4619833 0.0030728138 6.007216e-01 7.219199e-01 22 46411602 46411759 158 - 1.568 1.553 -0.052
ENSG00000075275 E051 31.9840988 0.0109126085 1.333975e-02 3.671141e-02 22 46433393 46433481 89 - 1.592 1.422 -0.584
ENSG00000075275 E052 33.0016984 0.0235085567 1.441460e-02 3.916621e-02 22 46436174 46436289 116 - 1.629 1.418 -0.723
ENSG00000075275 E053 35.5711839 0.0014996156 6.374386e-05 3.497577e-04 22 46439189 46439411 223 - 1.665 1.441 -0.767
ENSG00000075275 E054 0.1451727 0.0434539203 4.280082e-01   22 46462779 46462918 140 - 0.128 0.000 -12.235
ENSG00000075275 E055 65.0809421 0.0003784552 1.991845e-03 7.201290e-03 22 46463707 46464345 639 - 1.871 1.753 -0.399
ENSG00000075275 E056 2.3980610 0.0166767634 1.859914e-01 3.087341e-01 22 46530308 46530500 193 - 0.375 0.612 1.171
ENSG00000075275 E057 285.7197618 0.0033843501 6.144386e-12 1.323219e-10 22 46533627 46537620 3994 - 2.552 2.354 -0.660