ENSG00000075240

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361034 ENSG00000075240 HEK293_OSMI2_2hA HEK293_TMG_2hB GRAMD4 protein_coding protein_coding 10.33026 11.67418 8.634166 1.160614 0.2455477 -0.4347577 3.9540178 5.109343 1.093922 0.6908976 1.0939221 -2.213320 0.36998750 0.4472667 0.1343333 -0.3129333 1.164337e-01 4.578173e-10 FALSE TRUE
ENST00000408031 ENSG00000075240 HEK293_OSMI2_2hA HEK293_TMG_2hB GRAMD4 protein_coding protein_coding 10.33026 11.67418 8.634166 1.160614 0.2455477 -0.4347577 1.3390661 3.371886 0.000000 1.0464717 0.0000000 -8.401684 0.11327083 0.2818333 0.0000000 -0.2818333 4.578173e-10 4.578173e-10 FALSE FALSE
ENST00000456069 ENSG00000075240 HEK293_OSMI2_2hA HEK293_TMG_2hB GRAMD4 protein_coding protein_coding 10.33026 11.67418 8.634166 1.160614 0.2455477 -0.4347577 0.7645103 0.300973 1.246841 0.2410745 0.2693704 2.014941 0.07328333 0.0225000 0.1435667 0.1210667 4.882688e-02 4.578173e-10 FALSE FALSE
MSTRG.22342.2 ENSG00000075240 HEK293_OSMI2_2hA HEK293_TMG_2hB GRAMD4 protein_coding   10.33026 11.67418 8.634166 1.160614 0.2455477 -0.4347577 4.1041148 2.891976 6.034041 0.2481983 1.0382794 1.058478 0.42452083 0.2484000 0.6930000 0.4446000 1.142540e-03 4.578173e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000075240 E001 0.0000000       22 46576012 46576078 67 +      
ENSG00000075240 E002 1.6326522 0.0088440079 3.189616e-05 1.885553e-04 22 46577100 46577128 29 + 0.692 0.000 -12.417
ENSG00000075240 E003 19.5888210 0.0043454196 2.143003e-05 1.319120e-04 22 46577129 46577290 162 + 1.453 1.158 -1.032
ENSG00000075240 E004 0.0000000       22 46620386 46620565 180 +      
ENSG00000075240 E005 17.4872526 0.0014141842 1.156742e-03 4.494286e-03 22 46626751 46626760 10 + 1.370 1.158 -0.744
ENSG00000075240 E006 35.5339393 0.0149787759 4.641726e-03 1.493632e-02 22 46626761 46626842 82 + 1.654 1.471 -0.623
ENSG00000075240 E007 47.2781258 0.0007970003 5.803145e-04 2.461189e-03 22 46626843 46626916 74 + 1.741 1.618 -0.419
ENSG00000075240 E008 42.7211148 0.0006426933 5.471547e-04 2.336350e-03 22 46626917 46626961 45 + 1.703 1.572 -0.447
ENSG00000075240 E009 54.3475762 0.0004830228 3.807892e-03 1.260230e-02 22 46637840 46637960 121 + 1.779 1.695 -0.285
ENSG00000075240 E010 56.7470825 0.0010625076 9.665357e-03 2.794031e-02 22 46658187 46658307 121 + 1.789 1.718 -0.240
ENSG00000075240 E011 39.3652392 0.0026669594 9.846160e-02 1.881601e-01 22 46661381 46661442 62 + 1.619 1.573 -0.157
ENSG00000075240 E012 41.4279640 0.0007216736 6.017998e-01 7.228672e-01 22 46663040 46663106 67 + 1.600 1.624 0.082
ENSG00000075240 E013 42.3133456 0.0019892954 5.425160e-01 6.732559e-01 22 46663107 46663172 66 + 1.615 1.633 0.062
ENSG00000075240 E014 40.5525507 0.0005995854 6.222567e-01 7.390842e-01 22 46663838 46663863 26 + 1.592 1.618 0.087
ENSG00000075240 E015 67.4791083 0.0004304978 1.856186e-02 4.836721e-02 22 46664026 46664117 92 + 1.852 1.805 -0.160
ENSG00000075240 E016 65.8709573 0.0004161425 2.467683e-04 1.161883e-03 22 46665615 46665706 92 + 1.873 1.769 -0.353
ENSG00000075240 E017 49.9931766 0.0021426429 1.089774e-02 3.091839e-02 22 46666825 46666873 49 + 1.744 1.663 -0.276
ENSG00000075240 E018 53.7728160 0.0070632866 3.915121e-02 8.946156e-02 22 46668096 46668167 72 + 1.768 1.697 -0.241
ENSG00000075240 E019 43.8896867 0.0112051022 2.231360e-01 3.541356e-01 22 46668689 46668732 44 + 1.661 1.629 -0.109
ENSG00000075240 E020 56.7047570 0.0068826890 4.454720e-01 5.870065e-01 22 46668799 46668908 110 + 1.747 1.755 0.027
ENSG00000075240 E021 2.7281628 0.0054974464 1.812309e-01 3.027712e-01 22 46671050 46671167 118 + 0.659 0.489 -0.774
ENSG00000075240 E022 70.6139909 0.0004447206 9.900278e-01 9.978570e-01 22 46672843 46672997 155 + 1.809 1.862 0.179
ENSG00000075240 E023 81.0662332 0.0070756483 8.333415e-01 8.955998e-01 22 46673670 46673814 145 + 1.865 1.931 0.222
ENSG00000075240 E024 0.3686942 0.0285621617 8.257363e-01 8.902771e-01 22 46674608 46674656 49 + 0.132 0.113 -0.257
ENSG00000075240 E025 77.3195094 0.0046144146 2.072373e-01 3.352158e-01 22 46674657 46674750 94 + 1.890 1.881 -0.029
ENSG00000075240 E026 75.4329930 0.0139056318 6.857065e-01 7.883693e-01 22 46675468 46675552 85 + 1.859 1.889 0.104
ENSG00000075240 E027 63.1949230 0.0010999969 4.402381e-01 5.819179e-01 22 46676600 46676668 69 + 1.744 1.834 0.303
ENSG00000075240 E028 709.4868043 0.0043256076 2.690446e-11 5.220700e-10 22 46677147 46679790 2644 + 2.701 2.920 0.727