ENSG00000075234

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381031 ENSG00000075234 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC38 protein_coding protein_coding 32.84348 52.43726 20.79865 3.429116 0.2518336 -1.333684 22.6715696 39.1670726 13.277219 3.1506676 0.51162684 -1.559970 0.66672500 0.7454000 0.6387333 -0.1066667 0.043651271 6.687381e-10 FALSE TRUE
ENST00000417709 ENSG00000075234 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC38 protein_coding nonsense_mediated_decay 32.84348 52.43726 20.79865 3.429116 0.2518336 -1.333684 0.9744375 0.5720958 1.587008 0.2956206 0.10466406 1.456043 0.03879167 0.0104000 0.0762000 0.0658000 0.000520458 6.687381e-10 FALSE FALSE
MSTRG.22338.3 ENSG00000075234 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC38 protein_coding   32.84348 52.43726 20.79865 3.429116 0.2518336 -1.333684 6.4054053 9.4996276 3.700045 1.8292863 0.08992282 -1.357952 0.20108750 0.1779667 0.1778667 -0.0001000 1.000000000 6.687381e-10 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000075234 E001 0.5159433 0.2229553639 1.986592e-01 3.245130e-01 22 46267961 46267963 3 + 0.314 0.080 -2.386
ENSG00000075234 E002 0.8825612 0.1494438575 1.542601e-01 2.674609e-01 22 46267964 46267980 17 + 0.413 0.148 -1.963
ENSG00000075234 E003 17.6624990 0.0010911906 1.871280e-01 3.101397e-01 22 46267981 46268007 27 + 1.267 1.176 -0.323
ENSG00000075234 E004 139.8759364 0.0021810199 1.645754e-10 2.799023e-09 22 46268008 46268039 32 + 2.225 2.011 -0.717
ENSG00000075234 E005 184.7423915 0.0013719355 3.249854e-08 3.634446e-07 22 46268040 46268072 33 + 2.303 2.152 -0.504
ENSG00000075234 E006 242.5584968 0.0014402849 1.207185e-07 1.207420e-06 22 46268514 46268591 78 + 2.406 2.278 -0.427
ENSG00000075234 E007 1.0642801 0.0122964248 1.352839e-02 3.714527e-02 22 46268592 46268927 336 + 0.562 0.146 -2.731
ENSG00000075234 E008 9.6637379 0.0018119116 2.822821e-12 6.434544e-11 22 46269142 46269289 148 + 1.367 0.663 -2.630
ENSG00000075234 E009 198.5661933 0.0005049693 2.130135e-10 3.549857e-09 22 46272335 46272371 37 + 2.336 2.182 -0.513
ENSG00000075234 E010 171.5160015 0.0007941726 1.107865e-05 7.286292e-05 22 46272372 46272416 45 + 2.244 2.132 -0.375
ENSG00000075234 E011 293.1761440 0.0006562228 1.750735e-02 4.605844e-02 22 46273898 46274069 172 + 2.418 2.386 -0.106
ENSG00000075234 E012 320.7672529 0.0005025025 7.423474e-02 1.503058e-01 22 46275248 46275421 174 + 2.443 2.429 -0.047
ENSG00000075234 E013 248.1424966 0.0009072218 2.966168e-02 7.129936e-02 22 46278586 46278661 76 + 2.347 2.314 -0.108
ENSG00000075234 E014 5.0488013 0.0033610894 8.615082e-01 9.146807e-01 22 46280069 46280242 174 + 0.720 0.716 -0.016
ENSG00000075234 E015 172.6899602 0.0002261530 2.954053e-01 4.365405e-01 22 46281599 46281620 22 + 2.167 2.162 -0.017
ENSG00000075234 E016 263.9970350 0.0002547061 8.468085e-01 9.048089e-01 22 46281621 46281718 98 + 2.323 2.356 0.110
ENSG00000075234 E017 7.6425180 0.0022694201 6.713644e-04 2.793805e-03 22 46281971 46282151 181 + 1.120 0.748 -1.408
ENSG00000075234 E018 195.9519459 0.0002068634 6.717258e-02 1.386462e-01 22 46283973 46284032 60 + 2.154 2.237 0.277
ENSG00000075234 E019 194.8089492 0.0002230753 3.141885e-01 4.568780e-01 22 46285241 46285279 39 + 2.171 2.229 0.193
ENSG00000075234 E020 211.6270894 0.0001858313 6.683493e-02 1.381163e-01 22 46287073 46287154 82 + 2.188 2.269 0.270
ENSG00000075234 E021 239.4439017 0.0002910233 8.115206e-02 1.613360e-01 22 46288423 46288509 87 + 2.246 2.322 0.254
ENSG00000075234 E022 238.0733278 0.0005742869 5.198529e-01 6.539285e-01 22 46288510 46288588 79 + 2.266 2.313 0.156
ENSG00000075234 E023 330.9777210 0.0051574606 5.046452e-01 6.405596e-01 22 46289402 46289561 160 + 2.404 2.462 0.194
ENSG00000075234 E024 242.7921721 0.0056598460 6.585667e-01 7.676619e-01 22 46289826 46289899 74 + 2.277 2.326 0.164
ENSG00000075234 E025 67.9197773 0.0004386895 1.732015e-02 4.564773e-02 22 46292203 46292328 126 + 1.643 1.795 0.514
ENSG00000075234 E026 1246.3690843 0.0028331772 3.203578e-13 8.476373e-12 22 46292791 46294008 1218 + 2.861 3.066 0.684