ENSG00000075188

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251074 ENSG00000075188 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP37 protein_coding protein_coding 48.56813 30.69279 70.55361 6.334318 1.39327 1.200555 28.988642 21.2470900 38.924685 4.8662116 0.3613654 0.8731118 0.6182792 0.687066667 0.5520333 -0.13503333 0.0005319319 0.0005319319 FALSE TRUE
ENST00000543021 ENSG00000075188 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP37 protein_coding processed_transcript 48.56813 30.69279 70.55361 6.334318 1.39327 1.200555 2.667448 0.4001806 6.469301 0.4001806 1.4205586 3.9815068 0.0482875 0.009266667 0.0910000 0.08173333 0.0511506442 0.0005319319 FALSE TRUE
ENST00000548994 ENSG00000075188 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP37 protein_coding processed_transcript 48.56813 30.69279 70.55361 6.334318 1.39327 1.200555 4.863074 1.5635633 10.206217 1.5635633 2.7609118 2.6987540 0.0967625 0.060266667 0.1452000 0.08493333 0.1657524715 0.0005319319   FALSE
ENST00000551744 ENSG00000075188 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP37 protein_coding protein_coding 48.56813 30.69279 70.55361 6.334318 1.39327 1.200555 7.382475 5.6104112 6.781846 1.5024007 3.4252241 0.2731280 0.1452083 0.181066667 0.0962000 -0.08486667 0.7293327867 0.0005319319 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000075188 E001 7.446986 0.0023166556 5.968335e-01 7.187116e-01 12 102073103 102073195 93 - 0.894 0.965 0.266
ENSG00000075188 E002 33.221376 0.0006205917 3.599327e-03 1.200940e-02 12 102073196 102073724 529 - 1.592 1.417 -0.601
ENSG00000075188 E003 18.633031 0.0013258541 1.365757e-02 3.744589e-02 12 102073725 102073995 271 - 1.357 1.159 -0.696
ENSG00000075188 E004 6.363233 0.0049921430 1.560834e-02 4.186482e-02 12 102073996 102074188 193 - 0.969 0.650 -1.263
ENSG00000075188 E005 2.106587 0.0086079938 3.317091e-01 4.753466e-01 12 102074189 102074196 8 - 0.433 0.605 0.822
ENSG00000075188 E006 15.785142 0.0024746601 3.746962e-09 4.993673e-08 12 102074197 102074244 48 - 0.945 1.470 1.866
ENSG00000075188 E007 66.508538 0.0121449569 9.897600e-05 5.170469e-04 12 102074245 102074359 115 - 1.698 1.970 0.915
ENSG00000075188 E008 218.806733 0.0009533845 4.243422e-09 5.597824e-08 12 102074360 102074435 76 - 2.267 2.437 0.567
ENSG00000075188 E009 212.254641 0.0012875817 9.687708e-06 6.462122e-05 12 102074436 102074467 32 - 2.268 2.408 0.466
ENSG00000075188 E010 292.261347 0.0045880491 9.361405e-02 1.807784e-01 12 102075001 102075094 94 - 2.434 2.504 0.234
ENSG00000075188 E011 209.342328 0.0001986867 3.753179e-02 8.646615e-02 12 102076797 102076847 51 - 2.298 2.361 0.208
ENSG00000075188 E012 2.214268 0.0955129735 2.726835e-01 4.116388e-01 12 102076848 102076992 145 - 0.392 0.609 1.063
ENSG00000075188 E013 2.967693 0.1743503157 8.285159e-01 8.922229e-01 12 102076993 102077321 329 - 0.568 0.611 0.193
ENSG00000075188 E014 399.264881 0.0001290885 7.516505e-02 1.518021e-01 12 102077322 102077503 182 - 2.586 2.627 0.139
ENSG00000075188 E015 1.619964 0.0114625081 6.696546e-01 7.763834e-01 12 102079059 102079077 19 - 0.433 0.362 -0.394
ENSG00000075188 E016 4.367031 0.0561643176 2.912857e-01 4.321417e-01 12 102079078 102079216 139 - 0.788 0.605 -0.760
ENSG00000075188 E017 255.966384 0.0017580470 9.221726e-01 9.549108e-01 12 102085766 102085856 91 - 2.408 2.407 -0.004
ENSG00000075188 E018 239.241839 0.0013333898 9.686273e-01 9.843640e-01 12 102099106 102099200 95 - 2.377 2.382 0.017
ENSG00000075188 E019 196.749902 0.0026216731 3.457669e-01 4.898999e-01 12 102101032 102101104 73 - 2.305 2.275 -0.102
ENSG00000075188 E020 213.706582 0.0020707285 1.932588e-02 5.003937e-02 12 102112108 102112174 67 - 2.357 2.289 -0.229
ENSG00000075188 E021 216.425179 0.0002095064 1.012439e-05 6.719812e-05 12 102112175 102112232 58 - 2.374 2.275 -0.330
ENSG00000075188 E022 1.187683 0.0108337366 1.294269e-01 2.333683e-01 12 102115803 102115864 62 - 0.433 0.157 -1.977
ENSG00000075188 E023 150.057170 0.0002368045 2.595188e-06 1.970543e-05 12 102118363 102118364 2 - 2.226 2.095 -0.438
ENSG00000075188 E024 332.581530 0.0001828939 1.395579e-09 2.014694e-08 12 102118365 102118583 219 - 2.564 2.453 -0.369
ENSG00000075188 E025 1.511236 0.0094719634 4.055697e-01 5.492495e-01 12 102118995 102119420 426 - 0.347 0.500 0.823
ENSG00000075188 E026 128.291961 0.0002557447 1.616308e-05 1.024083e-04 12 102120050 102120120 71 - 2.159 2.030 -0.433