ENSG00000075142

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265729 ENSG00000075142 HEK293_OSMI2_2hA HEK293_TMG_2hB SRI protein_coding protein_coding 166.7205 225.0922 139.42 33.02236 2.809539 -0.6910393 12.09309 10.38377 17.621921 1.499602 0.8946773 0.7624712 0.07544583 0.04776667 0.12640000 0.07863333 9.120948e-05 3.113931e-08 FALSE  
ENST00000472930 ENSG00000075142 HEK293_OSMI2_2hA HEK293_TMG_2hB SRI protein_coding retained_intron 166.7205 225.0922 139.42 33.02236 2.809539 -0.6910393 15.61585 25.27063 6.436365 6.049774 0.6592362 -1.9714747 0.08973750 0.10860000 0.04633333 -0.06226667 1.457028e-03 3.113931e-08 FALSE  
MSTRG.30195.1 ENSG00000075142 HEK293_OSMI2_2hA HEK293_TMG_2hB SRI protein_coding   166.7205 225.0922 139.42 33.02236 2.809539 -0.6910393 132.56649 185.00774 107.056576 26.298393 2.2592694 -0.7891554 0.79310000 0.82310000 0.76803333 -0.05506667 1.833056e-02 3.113931e-08 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000075142 E001 0.4427912 1.516533e-01 3.046105e-01 4.466356e-01 7 88201626 88201715 90 - 0.279 0.091 -1.954
ENSG00000075142 E002 6.6277652 7.250054e-01 6.446355e-01 7.569044e-01 7 88203625 88203750 126 - 1.230 0.455 -3.110
ENSG00000075142 E003 156.7619205 1.690924e-02 5.307147e-08 5.689678e-07 7 88205115 88205657 543 - 2.401 1.999 -1.344
ENSG00000075142 E004 221.6623362 2.340856e-02 3.462548e-12 7.781367e-11 7 88205658 88206285 628 - 2.627 2.042 -1.950
ENSG00000075142 E005 445.6894772 1.585381e-04 5.376149e-01 6.691470e-01 7 88206286 88206404 119 - 2.640 2.615 -0.082
ENSG00000075142 E006 667.4613191 1.415839e-04 6.315190e-08 6.666975e-07 7 88206405 88206437 33 - 2.749 2.818 0.231
ENSG00000075142 E007 653.9569707 1.671196e-04 3.224507e-11 6.176675e-10 7 88206438 88206455 18 - 2.724 2.815 0.303
ENSG00000075142 E008 772.3524615 9.990556e-04 3.711922e-07 3.369490e-06 7 88206456 88206504 49 - 2.796 2.881 0.284
ENSG00000075142 E009 28.9015622 8.991330e-04 3.814458e-22 3.081610e-20 7 88207676 88208488 813 - 1.782 1.143 -2.206
ENSG00000075142 E010 4.1853887 4.015933e-02 5.405961e-02 1.163574e-01 7 88208489 88208506 18 - 0.891 0.578 -1.283
ENSG00000075142 E011 1216.7049732 8.509833e-04 3.386007e-03 1.139680e-02 7 88208507 88208565 59 - 3.031 3.063 0.105
ENSG00000075142 E012 1.2544922 1.086478e-02 2.355658e-03 8.325820e-03 7 88208860 88209338 479 - 0.619 0.092 -3.748
ENSG00000075142 E013 1676.5242548 4.070662e-04 4.490472e-02 1.000265e-01 7 88209339 88209432 94 - 3.189 3.195 0.021
ENSG00000075142 E014 935.2538631 4.215616e-04 8.313631e-01 8.943028e-01 7 88209433 88209452 20 - 2.951 2.937 -0.046
ENSG00000075142 E015 1520.9700720 9.531593e-05 1.801145e-02 4.715740e-02 7 88209983 88210082 100 - 3.148 3.157 0.029
ENSG00000075142 E016 964.9015555 1.784290e-04 3.026319e-02 7.248221e-02 7 88210083 88210130 48 - 2.947 2.959 0.040
ENSG00000075142 E017 19.4172904 3.546040e-03 1.711943e-11 3.429444e-10 7 88210131 88210493 363 - 1.580 1.017 -1.976
ENSG00000075142 E018 3.7071852 2.341725e-02 7.298076e-03 2.199629e-02 7 88210555 88210567 13 - 0.890 0.460 -1.848
ENSG00000075142 E019 8.9701703 1.871661e-03 1.098284e-08 1.343926e-07 7 88210568 88210881 314 - 1.300 0.677 -2.335
ENSG00000075142 E020 986.3942762 4.911429e-04 9.784173e-01 9.906458e-01 7 88210882 88210925 44 - 2.977 2.957 -0.068
ENSG00000075142 E021 2.3198150 1.855800e-02 3.477179e-02 8.120776e-02 7 88214795 88214936 142 - 0.704 0.338 -1.785
ENSG00000075142 E022 1053.2409214 1.425837e-03 8.985649e-02 1.749092e-01 7 88217122 88217191 70 - 3.029 2.970 -0.197
ENSG00000075142 E023 846.6688685 1.718259e-03 7.550116e-02 1.523104e-01 7 88218859 88218942 84 - 2.939 2.873 -0.221
ENSG00000075142 E024 460.6242149 6.088950e-03 2.618758e-01 3.996067e-01 7 88219976 88220065 90 - 2.681 2.604 -0.256
ENSG00000075142 E025 0.1472490 4.452723e-02 2.740113e-01   7 88226909 88226993 85 - 0.162 0.000 -10.133