ENSG00000074657

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000586085 ENSG00000074657 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF532 protein_coding protein_coding 2.553071 2.547263 3.559131 0.09321469 0.3078489 0.4809721 0.07959142 0.00000000 0.3039971 0.00000000 0.06801994 4.9726793 0.0237250 0.000000000 0.08443333 0.08443333 8.299997e-05 5.75764e-09 FALSE TRUE
ENST00000588601 ENSG00000074657 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF532 protein_coding protein_coding 2.553071 2.547263 3.559131 0.09321469 0.3078489 0.4809721 0.15282999 0.01835743 0.5203507 0.01835743 0.07187783 4.2251479 0.0516875 0.007033333 0.14633333 0.13930000 1.050143e-05 5.75764e-09 FALSE TRUE
ENST00000589288 ENSG00000074657 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF532 protein_coding protein_coding 2.553071 2.547263 3.559131 0.09321469 0.3078489 0.4809721 0.69101984 0.94565713 0.8438632 0.18126683 0.42684575 -0.1624881 0.2872000 0.373066667 0.23120000 -0.14186667 7.152360e-01 5.75764e-09 FALSE TRUE
ENST00000591083 ENSG00000074657 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF532 protein_coding protein_coding 2.553071 2.547263 3.559131 0.09321469 0.3078489 0.4809721 0.07446224 0.00000000 0.2069208 0.00000000 0.13594809 4.4390966 0.0269125 0.000000000 0.06080000 0.06080000 2.966755e-01 5.75764e-09 FALSE TRUE
ENST00000591230 ENSG00000074657 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF532 protein_coding protein_coding 2.553071 2.547263 3.559131 0.09321469 0.3078489 0.4809721 0.28577434 0.07744349 0.1191204 0.07744349 0.11912038 0.5622938 0.1085792 0.029000000 0.03720000 0.00820000 9.615980e-01 5.75764e-09 FALSE TRUE
ENST00000591808 ENSG00000074657 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF532 protein_coding protein_coding 2.553071 2.547263 3.559131 0.09321469 0.3078489 0.4809721 0.24885337 0.08907107 0.6357716 0.04546383 0.06411900 2.7044882 0.1010750 0.035766667 0.18396667 0.14820000 6.715200e-03 5.75764e-09 FALSE TRUE
ENST00000592249 ENSG00000074657 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF532 protein_coding processed_transcript 2.553071 2.547263 3.559131 0.09321469 0.3078489 0.4809721 0.32663394 0.93468727 0.0000000 0.25271743 0.00000000 -6.5617649 0.1362000 0.365400000 0.00000000 -0.36540000 5.757640e-09 5.75764e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000074657 E001 0.1451727 0.0428605991 6.334562e-01   18 58862600 58862947 348 + 0.106 0.000 -9.903
ENSG00000074657 E002 0.5891098 0.0184884969 6.854393e-02 1.409546e-01 18 58862948 58863166 219 + 0.323 0.000 -13.973
ENSG00000074657 E003 2.5380300 0.0066472469 5.842149e-04 2.475459e-03 18 58863483 58863561 79 + 0.734 0.141 -3.526
ENSG00000074657 E004 4.1538546 0.0093835959 2.189170e-03 7.808477e-03 18 58863562 58863603 42 + 0.866 0.404 -2.048
ENSG00000074657 E005 3.8614329 0.0058818409 4.334451e-03 1.408126e-02 18 58863604 58863612 9 + 0.832 0.404 -1.917
ENSG00000074657 E006 5.2212432 0.0325559783 1.876305e-03 6.841827e-03 18 58863613 58863686 74 + 0.954 0.466 -2.055
ENSG00000074657 E007 2.6572801 0.0056765221 1.432503e-05 9.178281e-05 18 58863687 58863750 64 + 0.776 0.000 -15.635
ENSG00000074657 E008 0.4417591 0.0706381771 4.417391e-01 5.833819e-01 18 58864091 58864092 2 + 0.106 0.246 1.463
ENSG00000074657 E009 0.5900522 0.2628710959 3.377667e-01 4.816582e-01 18 58864093 58864235 143 + 0.106 0.324 2.008
ENSG00000074657 E010 0.8062886 0.0192242915 2.851919e-01 4.255003e-01 18 58864409 58864529 121 + 0.323 0.141 -1.524
ENSG00000074657 E011 1.2587586 0.0111595124 6.296813e-02 1.316579e-01 18 58864821 58864876 56 + 0.467 0.141 -2.332
ENSG00000074657 E012 0.9557277 0.0156801892 1.735359e-01 2.927763e-01 18 58864877 58864887 11 + 0.377 0.141 -1.846
ENSG00000074657 E013 0.9557277 0.0156801892 1.735359e-01 2.927763e-01 18 58864888 58864893 6 + 0.377 0.141 -1.846
ENSG00000074657 E014 1.4027854 0.0096697865 1.936285e-01 3.183484e-01 18 58864894 58864986 93 + 0.467 0.247 -1.333
ENSG00000074657 E015 3.4010233 0.0045154702 1.392953e-02 3.806410e-02 18 58864987 58865303 317 + 0.776 0.404 -1.696
ENSG00000074657 E016 6.1790592 0.0051059315 2.582504e-03 9.011909e-03 18 58865304 58865385 82 + 0.993 0.610 -1.525
ENSG00000074657 E017 8.1762384 0.0125468868 8.524147e-04 3.446241e-03 18 58865470 58865553 84 + 1.100 0.686 -1.589
ENSG00000074657 E018 6.5005094 0.0646122782 1.323946e-01 2.374154e-01 18 58865554 58865579 26 + 0.967 0.722 -0.952
ENSG00000074657 E019 0.2903454 0.3355736369 3.794969e-01   18 58896425 58896622 198 + 0.190 0.000 -12.412
ENSG00000074657 E020 101.8812486 0.0060622519 4.008709e-07 3.613446e-06 18 58918271 58920320 2050 + 2.093 1.890 -0.683
ENSG00000074657 E021 7.4543746 0.0049140704 6.157195e-01 7.339239e-01 18 58920321 58920329 9 + 0.955 0.918 -0.139
ENSG00000074657 E022 6.6418330 0.0026090482 1.582244e-01 2.727516e-01 18 58920330 58920333 4 + 0.955 0.804 -0.578
ENSG00000074657 E023 17.0584863 0.0011353062 3.121585e-01 4.546870e-01 18 58920334 58920522 189 + 1.284 1.223 -0.213
ENSG00000074657 E024 11.8114223 0.0188229056 7.493910e-01 8.363508e-01 18 58920523 58920633 111 + 1.081 1.135 0.192
ENSG00000074657 E025 1.3984303 0.0100225137 9.395350e-01 9.660410e-01 18 58931646 58931755 110 + 0.377 0.404 0.151
ENSG00000074657 E026 0.6976476 0.0199129280 7.807183e-01 8.591071e-01 18 58932387 58932515 129 + 0.191 0.248 0.477
ENSG00000074657 E027 0.6642364 0.0539522194 7.843508e-01 8.616799e-01 18 58934232 58934432 201 + 0.191 0.247 0.475
ENSG00000074657 E028 14.6590431 0.0087838313 4.120639e-01 5.556215e-01 18 58934433 58934614 182 + 1.146 1.243 0.345
ENSG00000074657 E029 8.7628104 0.0024480600 4.624434e-01 6.022983e-01 18 58939445 58939512 68 + 0.941 1.040 0.367
ENSG00000074657 E030 13.7053512 0.0015050136 5.582531e-02 1.193874e-01 18 58939513 58939621 109 + 1.060 1.252 0.686
ENSG00000074657 E031 0.0000000       18 58939800 58940430 631 +      
ENSG00000074657 E032 16.3021263 0.0073810117 2.056978e-01 3.332868e-01 18 58948067 58948183 117 + 1.171 1.305 0.473
ENSG00000074657 E033 12.2163116 0.0049318611 9.519917e-01 9.739489e-01 18 58948184 58948229 46 + 1.119 1.135 0.056
ENSG00000074657 E034 0.0000000       18 58953184 58953282 99 +      
ENSG00000074657 E035 26.6176028 0.0008534752 3.585470e-01 5.029667e-01 18 58953518 58953799 282 + 1.403 1.485 0.281
ENSG00000074657 E036 0.4783925 0.0222556963 7.413526e-01 8.305609e-01 18 58954234 58954334 101 + 0.191 0.141 -0.526
ENSG00000074657 E037 0.0000000       18 58964086 58964116 31 +      
ENSG00000074657 E038 0.0000000       18 58964117 58964251 135 +      
ENSG00000074657 E039 0.0000000       18 58977490 58977668 179 +      
ENSG00000074657 E040 18.8772764 0.0010323551 3.461830e-01 4.903426e-01 18 58979055 58979167 113 + 1.258 1.352 0.326
ENSG00000074657 E041 0.9974562 0.0132559631 7.369261e-01 8.272409e-01 18 58979168 58979491 324 + 0.262 0.333 0.474
ENSG00000074657 E042 1.2533714 0.0124378533 7.035413e-01 8.022282e-01 18 58979567 58981469 1903 + 0.323 0.404 0.472
ENSG00000074657 E043 17.7638043 0.0012031437 1.770407e-01 2.973943e-01 18 58981470 58981617 148 + 1.216 1.344 0.447
ENSG00000074657 E044 125.6441556 0.0100317685 1.810121e-10 3.056073e-09 18 58983972 58986480 2509 + 1.931 2.242 1.043