ENSG00000074603

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300141 ENSG00000074603 HEK293_OSMI2_2hA HEK293_TMG_2hB DPP8 protein_coding protein_coding 8.919611 3.904462 15.23324 0.2478896 0.1920936 1.961283 4.3386711 1.6973972 7.9671438 0.039655924 0.2283567 2.2240735 0.46760833 0.43903333 0.523233333 0.08420000 3.137601e-01 3.265883e-05 FALSE TRUE
ENST00000321147 ENSG00000074603 HEK293_OSMI2_2hA HEK293_TMG_2hB DPP8 protein_coding protein_coding 8.919611 3.904462 15.23324 0.2478896 0.1920936 1.961283 0.9249565 0.1562119 2.1254895 0.009322472 0.3818632 3.6834713 0.08116250 0.04003333 0.140200000 0.10016667 9.360181e-03 3.265883e-05 FALSE TRUE
ENST00000560194 ENSG00000074603 HEK293_OSMI2_2hA HEK293_TMG_2hB DPP8 protein_coding processed_transcript 8.919611 3.904462 15.23324 0.2478896 0.1920936 1.961283 1.5735187 1.5565255 1.7874502 0.355811988 0.1208339 0.1983835 0.23960833 0.39056667 0.117166667 -0.27340000 3.265883e-05 3.265883e-05 FALSE TRUE
ENST00000560436 ENSG00000074603 HEK293_OSMI2_2hA HEK293_TMG_2hB DPP8 protein_coding protein_coding 8.919611 3.904462 15.23324 0.2478896 0.1920936 1.961283 0.0582863 0.2044557 0.0711120 0.102965552 0.0711120 -1.4026923 0.01263750 0.05593333 0.004633333 -0.05130000 3.377822e-01 3.265883e-05 FALSE FALSE
MSTRG.11056.3 ENSG00000074603 HEK293_OSMI2_2hA HEK293_TMG_2hB DPP8 protein_coding   8.919611 3.904462 15.23324 0.2478896 0.1920936 1.961283 0.2534890 0.0000000 0.7776723 0.000000000 0.1731374 6.2995236 0.01907083 0.00000000 0.050833333 0.05083333 2.175549e-04 3.265883e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000074603 E001 0.0000000       15 65442463 65442466 4 -      
ENSG00000074603 E002 541.0463652 0.0003645763 1.596140e-56 1.419643e-53 15 65442467 65446616 4150 - 2.561 2.822 0.868
ENSG00000074603 E003 9.7767365 0.0022320716 4.851071e-01 6.230523e-01 15 65446617 65446620 4 - 0.903 1.003 0.374
ENSG00000074603 E004 11.2737930 0.0015617622 6.415039e-01 7.545228e-01 15 65446621 65446636 16 - 0.967 1.035 0.250
ENSG00000074603 E005 8.2605067 0.0035446762 8.477708e-01 9.054745e-01 15 65446637 65446651 15 - 0.855 0.893 0.143
ENSG00000074603 E006 25.4725163 0.0008472170 5.813389e-02 1.234259e-01 15 65446652 65446739 88 - 1.337 1.165 -0.607
ENSG00000074603 E007 15.7530215 0.0011540697 6.506524e-02 1.351418e-01 15 65446740 65446740 1 - 1.147 0.933 -0.785
ENSG00000074603 E008 72.1723590 0.0010219115 7.981228e-03 2.373061e-02 15 65446741 65447006 266 - 1.775 1.629 -0.494
ENSG00000074603 E009 0.7696683 0.0160573247 2.028936e-01 3.298373e-01 15 65450739 65450998 260 - 0.152 0.400 1.846
ENSG00000074603 E010 47.5554988 0.0004742188 1.471556e-02 3.984876e-02 15 65450999 65451110 112 - 1.602 1.439 -0.558
ENSG00000074603 E011 41.6510971 0.0009343652 9.597996e-02 1.843494e-01 15 65451960 65452043 84 - 1.539 1.427 -0.388
ENSG00000074603 E012 38.3661282 0.0005644585 8.686097e-02 1.703702e-01 15 65452044 65452102 59 - 1.508 1.388 -0.415
ENSG00000074603 E013 36.6033167 0.0060284901 1.555476e-01 2.691267e-01 15 65454263 65454415 153 - 1.485 1.374 -0.383
ENSG00000074603 E014 3.7553476 0.0355776966 5.569668e-01 6.854962e-01 15 65455394 65455653 260 - 0.564 0.680 0.505
ENSG00000074603 E015 6.1889924 0.0039093215 2.492330e-01 3.850066e-01 15 65455654 65455711 58 - 0.791 0.605 -0.778
ENSG00000074603 E016 6.9856144 0.0047226702 8.085703e-01 8.784122e-01 15 65455712 65455841 130 - 0.801 0.848 0.183
ENSG00000074603 E017 32.4939729 0.0006512485 4.287338e-02 9.631260e-02 15 65456225 65456286 62 - 1.443 1.282 -0.561
ENSG00000074603 E018 41.0345172 0.0005236589 7.497789e-07 6.398062e-06 15 65456287 65456371 85 - 1.568 1.141 -1.487
ENSG00000074603 E019 51.6126087 0.0027145408 2.674804e-08 3.040706e-07 15 65463761 65463906 146 - 1.669 1.207 -1.596
ENSG00000074603 E020 45.4548909 0.0005110632 6.900262e-04 2.862849e-03 15 65466678 65466813 136 - 1.594 1.346 -0.854
ENSG00000074603 E021 45.5161663 0.0005138954 2.416219e-03 8.510060e-03 15 65467071 65467223 153 - 1.591 1.374 -0.744
ENSG00000074603 E022 29.5906996 0.0006437620 1.041835e-02 2.979343e-02 15 65474209 65474288 80 - 1.412 1.186 -0.788
ENSG00000074603 E023 46.3436615 0.0005050988 1.516272e-03 5.688745e-03 15 65478880 65479039 160 - 1.600 1.374 -0.775
ENSG00000074603 E024 56.8882864 0.0005723056 9.584312e-04 3.816268e-03 15 65480222 65480399 178 - 1.685 1.473 -0.722
ENSG00000074603 E025 40.9927558 0.0442570136 2.791518e-01 4.188637e-01 15 65481515 65481615 101 - 1.534 1.423 -0.383
ENSG00000074603 E026 30.9292371 0.0055496818 4.227280e-01 5.658646e-01 15 65485099 65485160 62 - 1.407 1.346 -0.211
ENSG00000074603 E027 38.0152889 0.0005700770 2.157852e-01 3.453449e-01 15 65487690 65487818 129 - 1.497 1.414 -0.286
ENSG00000074603 E028 39.8047460 0.0005371515 1.170795e-02 3.283659e-02 15 65490189 65490299 111 - 1.532 1.346 -0.644
ENSG00000074603 E029 36.5396215 0.0006485452 7.528379e-04 3.089616e-03 15 65497864 65497916 53 - 1.507 1.227 -0.971
ENSG00000074603 E030 32.0675480 0.0006494786 5.219353e-04 2.241800e-03 15 65497917 65497950 34 - 1.454 1.141 -1.096
ENSG00000074603 E031 44.0165574 0.0005281405 4.064771e-04 1.799623e-03 15 65497951 65498032 82 - 1.581 1.315 -0.918
ENSG00000074603 E032 58.0177438 0.0004854421 1.428956e-06 1.147714e-05 15 65500606 65500779 174 - 1.707 1.374 -1.137
ENSG00000074603 E033 34.4879272 0.0244654613 1.222836e-04 6.242591e-04 15 65507243 65507302 60 - 1.498 1.006 -1.736
ENSG00000074603 E034 33.5568283 0.0012614518 1.112226e-05 7.312434e-05 15 65507303 65507355 53 - 1.483 1.064 -1.475
ENSG00000074603 E035 8.3838851 0.0355960353 1.301327e-06 1.054639e-05 15 65511961 65512108 148 - 0.653 1.339 2.570
ENSG00000074603 E036 28.2383366 0.0021009303 3.196758e-01 4.627724e-01 15 65512295 65512301 7 - 1.375 1.298 -0.266
ENSG00000074603 E037 87.8034264 0.0023625942 1.405116e-03 5.323154e-03 15 65512302 65512564 263 - 1.805 1.975 0.574
ENSG00000074603 E038 1.1575045 0.2636377305 1.246056e-01 2.265661e-01 15 65512565 65512831 267 - 0.194 0.516 2.015
ENSG00000074603 E039 14.7219865 0.0016828628 8.133241e-04 3.306619e-03 15 65515656 65515791 136 - 1.005 1.346 1.217
ENSG00000074603 E040 5.2507616 0.0575948358 3.055805e-02 7.306280e-02 15 65515792 65517205 1414 - 0.596 0.975 1.517
ENSG00000074603 E041 0.4439371 0.0215759821 8.910200e-01 9.344026e-01 15 65517206 65517338 133 - 0.152 0.000 -10.821
ENSG00000074603 E042 0.3030308 0.3853331350 1.000000e+00   15 65517381 65517485 105 - 0.108 0.001 -7.900
ENSG00000074603 E043 42.8721704 0.0032942784 3.955001e-03 1.301685e-02 15 65517486 65517704 219 - 1.487 1.694 0.705