ENSG00000074582

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359273 ENSG00000074582 HEK293_OSMI2_2hA HEK293_TMG_2hB BCS1L protein_coding protein_coding 108.8318 151.3776 71.60025 5.467787 1.424119 -1.080009 41.081112 73.375371 22.566498 3.1720177 0.3650004 -1.7006708 0.35844167 0.48466667 0.31560000 -0.16906667 3.652321e-10 3.07005e-18 FALSE TRUE
ENST00000392110 ENSG00000074582 HEK293_OSMI2_2hA HEK293_TMG_2hB BCS1L protein_coding protein_coding 108.8318 151.3776 71.60025 5.467787 1.424119 -1.080009 5.968302 11.205190 2.166607 0.6274119 0.5049661 -2.3653010 0.05057500 0.07420000 0.03056667 -0.04363333 2.705018e-02 3.07005e-18 FALSE TRUE
ENST00000431802 ENSG00000074582 HEK293_OSMI2_2hA HEK293_TMG_2hB BCS1L protein_coding protein_coding 108.8318 151.3776 71.60025 5.467787 1.424119 -1.080009 5.793894 3.652888 5.482386 0.2367102 0.3016938 0.5844514 0.05982917 0.02430000 0.07680000 0.05250000 6.956856e-10 3.07005e-18 FALSE TRUE
ENST00000490188 ENSG00000074582 HEK293_OSMI2_2hA HEK293_TMG_2hB BCS1L protein_coding retained_intron 108.8318 151.3776 71.60025 5.467787 1.424119 -1.080009 11.715987 7.906568 9.921812 0.3574236 0.3798698 0.3271818 0.11880833 0.05220000 0.13886667 0.08666667 3.070050e-18 3.07005e-18   FALSE
ENST00000493376 ENSG00000074582 HEK293_OSMI2_2hA HEK293_TMG_2hB BCS1L protein_coding retained_intron 108.8318 151.3776 71.60025 5.467787 1.424119 -1.080009 10.858366 7.017580 9.568285 1.4206561 0.5643947 0.4467394 0.11023750 0.04606667 0.13380000 0.08773333 2.356326e-04 3.07005e-18 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000074582 E001 0.9190056 0.0196105050 6.830172e-01 7.863363e-01 2 218658764 218658804 41 + 0.324 0.246 -0.536
ENSG00000074582 E002 19.1995412 0.0011465255 3.963045e-01 5.400879e-01 2 218658805 218659173 369 + 1.284 1.208 -0.270
ENSG00000074582 E003 8.4045287 0.0020935032 9.761801e-01 9.891020e-01 2 218659376 218659523 148 + 0.913 0.908 -0.022
ENSG00000074582 E004 2.6100560 0.0059349932 5.250002e-01 6.584158e-01 2 218659656 218659658 3 + 0.576 0.465 -0.528
ENSG00000074582 E005 6.0409710 0.0027814980 6.879770e-01 7.901975e-01 2 218659659 218659682 24 + 0.734 0.790 0.225
ENSG00000074582 E006 22.6044711 0.0305472869 5.781723e-01 7.033249e-01 2 218659683 218659708 26 + 1.343 1.273 -0.245
ENSG00000074582 E007 26.5786169 0.0223093309 1.586889e-01 2.733807e-01 2 218659709 218659713 5 + 1.466 1.320 -0.506
ENSG00000074582 E008 33.1929009 0.0167447754 3.136014e-01 4.562099e-01 2 218659714 218659716 3 + 1.520 1.427 -0.320
ENSG00000074582 E009 142.5882250 0.0002378366 1.578566e-01 2.722688e-01 2 218659717 218659736 20 + 2.115 2.065 -0.169
ENSG00000074582 E010 225.4205795 0.0001826985 8.431019e-01 9.022784e-01 2 218659737 218659743 7 + 2.270 2.273 0.011
ENSG00000074582 E011 29.9023268 0.0008419240 2.573791e-01 3.944896e-01 2 218659744 218659759 16 + 1.474 1.390 -0.287
ENSG00000074582 E012 36.4320880 0.0005748158 1.146238e-01 2.122818e-01 2 218659760 218659771 12 + 1.574 1.470 -0.355
ENSG00000074582 E013 46.9996888 0.0004846773 1.436766e-01 2.530150e-01 2 218659772 218659800 29 + 1.666 1.579 -0.294
ENSG00000074582 E014 59.4134853 0.0019686921 7.342064e-30 1.222260e-27 2 218659801 218660036 236 + 2.069 1.505 -1.907
ENSG00000074582 E015 146.6886272 0.0002905691 1.526890e-13 4.226544e-12 2 218660037 218660166 130 + 2.262 2.026 -0.791
ENSG00000074582 E016 62.9606665 0.0058228879 2.457088e-04 1.157383e-03 2 218660167 218660218 52 + 1.888 1.669 -0.739
ENSG00000074582 E017 57.0089271 0.0006726736 4.771190e-06 3.412828e-05 2 218660219 218660245 27 + 1.853 1.619 -0.790
ENSG00000074582 E018 59.5518337 0.0004311623 1.653153e-19 9.986761e-18 2 218660246 218660306 61 + 1.990 1.564 -1.441
ENSG00000074582 E019 175.2899990 0.0011639738 8.696610e-15 2.887394e-13 2 218660307 218660421 115 + 2.347 2.093 -0.850
ENSG00000074582 E020 63.6207879 0.0003726249 3.913386e-25 4.330486e-23 2 218660422 218660482 61 + 2.043 1.575 -1.582
ENSG00000074582 E021 60.8604925 0.0004253227 4.012766e-31 7.274702e-29 2 218660483 218660598 116 + 2.058 1.526 -1.800
ENSG00000074582 E022 47.1227433 0.0060454640 4.151466e-10 6.600224e-09 2 218660867 218660938 72 + 1.876 1.479 -1.349
ENSG00000074582 E023 560.1459549 0.0005495891 3.012562e-01 4.430444e-01 2 218660939 218661063 125 + 2.684 2.661 -0.076
ENSG00000074582 E024 964.2334606 0.0005540277 3.457550e-01 4.898903e-01 2 218661064 218661307 244 + 2.916 2.899 -0.057
ENSG00000074582 E025 17.1137178 0.0010676235 1.610703e-16 6.761420e-15 2 218661308 218661405 98 + 1.593 0.918 -2.390
ENSG00000074582 E026 691.1265515 0.0005561735 5.316990e-01 6.641093e-01 2 218661406 218661520 115 + 2.750 2.760 0.033
ENSG00000074582 E027 306.2850072 0.0001499006 2.683436e-04 1.250908e-03 2 218661521 218661545 25 + 2.336 2.424 0.293
ENSG00000074582 E028 9.2653898 0.0227838088 1.299847e-04 6.588155e-04 2 218661666 218661758 93 + 1.259 0.777 -1.783
ENSG00000074582 E029 606.8130555 0.0001251974 3.841143e-05 2.223593e-04 2 218661759 218661850 92 + 2.647 2.717 0.233
ENSG00000074582 E030 642.6098662 0.0001377564 1.713394e-03 6.323899e-03 2 218661851 218661917 67 + 2.688 2.739 0.170
ENSG00000074582 E031 569.8768224 0.0001514368 9.200654e-04 3.685018e-03 2 218661918 218661949 32 + 2.631 2.689 0.193
ENSG00000074582 E032 451.6466853 0.0001208033 2.878624e-02 6.957217e-02 2 218661950 218661953 4 + 2.542 2.583 0.138
ENSG00000074582 E033 641.0655529 0.0001219202 2.500745e-05 1.516319e-04 2 218662197 218662260 64 + 2.672 2.742 0.231
ENSG00000074582 E034 25.1549102 0.0120103647 1.992126e-06 1.550353e-05 2 218662261 218662509 249 + 1.623 1.215 -1.409
ENSG00000074582 E035 337.3329510 0.0005879487 1.083049e-05 7.139189e-05 2 218662510 218662514 5 + 2.361 2.473 0.375
ENSG00000074582 E036 910.7227497 0.0003858772 4.087697e-05 2.351090e-04 2 218662515 218662679 165 + 2.829 2.893 0.215
ENSG00000074582 E037 846.2855264 0.0001324703 5.670151e-03 1.774001e-02 2 218662883 218663000 118 + 2.817 2.855 0.129
ENSG00000074582 E038 750.3451529 0.0001358585 5.644131e-02 1.204953e-01 2 218663134 218663242 109 + 2.772 2.799 0.092
ENSG00000074582 E039 627.8822037 0.0001362558 2.312940e-04 1.097040e-03 2 218663243 218663443 201 + 2.669 2.730 0.204