ENSG00000074370

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397041 ENSG00000074370 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2A3 protein_coding protein_coding 1.598045 2.459555 1.275018 0.304096 0.0533146 -0.9424629 1.2600346 1.92115996 1.0892463 0.08889263 0.08354259 -0.812953 0.79977917 0.79803333 0.8542000 0.05616667 0.82142324 0.01753953 FALSE TRUE
ENST00000572176 ENSG00000074370 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2A3 protein_coding retained_intron 1.598045 2.459555 1.275018 0.304096 0.0533146 -0.9424629 0.1438962 0.37796694 0.0000000 0.24900396 0.00000000 -5.277862 0.06035000 0.13530000 0.0000000 -0.13530000 0.01753953 0.01753953 FALSE FALSE
ENST00000576957 ENSG00000074370 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2A3 protein_coding retained_intron 1.598045 2.459555 1.275018 0.304096 0.0533146 -0.9424629 0.1088934 0.07600664 0.1286845 0.02470614 0.03490672 0.689287 0.07889583 0.02943333 0.1005333 0.07110000 0.10945891 0.01753953 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000074370 E001 0.1515154 0.0429117787 0.2510897884   17 3923870 3923872 3 - 0.163 0.000 -10.036
ENSG00000074370 E002 0.1515154 0.0429117787 0.2510897884   17 3923873 3923874 2 - 0.163 0.000 -12.625
ENSG00000074370 E003 69.6818935 0.0005672762 0.0002200370 0.001049718 17 3923875 3924801 927 - 1.685 1.851 0.564
ENSG00000074370 E004 23.0534379 0.0011309442 0.0499979932 0.109173732 17 3924802 3925046 245 - 1.229 1.385 0.545
ENSG00000074370 E005 19.8836959 0.0024018337 0.1635225870 0.279723910 17 3925047 3925259 213 - 1.192 1.313 0.423
ENSG00000074370 E006 10.2226682 0.0018740676 0.5440796259 0.674582962 17 3925260 3925290 31 - 0.964 1.032 0.253
ENSG00000074370 E007 14.2063012 0.0014563125 0.5959864887 0.717983905 17 3925291 3925345 55 - 1.109 1.161 0.188
ENSG00000074370 E008 11.3016349 0.0033306770 0.6360465302 0.750167201 17 3925346 3925377 32 - 1.024 1.076 0.191
ENSG00000074370 E009 9.1562391 0.0109111999 0.3530197198 0.497263998 17 3925378 3925395 18 - 0.894 1.012 0.440
ENSG00000074370 E010 14.8221769 0.0036801029 0.6740055749 0.779547578 17 3925396 3925438 43 - 1.138 1.181 0.152
ENSG00000074370 E011 9.4829919 0.0263478504 0.8712656089 0.921205256 17 3925439 3925441 3 - 1.004 0.989 -0.056
ENSG00000074370 E012 0.0000000       17 3927981 3928038 58 -      
ENSG00000074370 E013 0.0000000       17 3928158 3928226 69 -      
ENSG00000074370 E014 0.0000000       17 3928227 3928239 13 -      
ENSG00000074370 E015 0.1482932 0.0420043047 1.0000000000   17 3928240 3928327 88 - 0.000 0.091 10.464
ENSG00000074370 E016 0.0000000       17 3928328 3928662 335 -      
ENSG00000074370 E017 19.8106889 0.0009800104 0.9581694130 0.977766294 17 3928663 3928780 118 - 1.284 1.282 -0.006
ENSG00000074370 E018 20.2015823 0.0011508190 0.4899597044 0.627324188 17 3929328 3929445 118 - 1.323 1.271 -0.181
ENSG00000074370 E019 23.8217085 0.0009006728 0.1652717980 0.282027531 17 3930301 3930434 134 - 1.423 1.327 -0.334
ENSG00000074370 E020 0.1482932 0.0420043047 1.0000000000   17 3930435 3930871 437 - 0.000 0.091 10.464
ENSG00000074370 E021 3.3086566 0.0049771419 0.0002364967 0.001118619 17 3934936 3935191 256 - 0.000 0.715 14.302
ENSG00000074370 E022 20.7115066 0.0010835786 0.9317355720 0.960997865 17 3935192 3935277 86 - 1.284 1.293 0.031
ENSG00000074370 E023 26.8904085 0.0007921593 0.4177425647 0.561062257 17 3936267 3936469 203 - 1.438 1.385 -0.183
ENSG00000074370 E024 1.6607623 0.0085169006 0.0934140964 0.180454785 17 3936470 3937087 618 - 0.572 0.286 -1.554
ENSG00000074370 E025 22.4980929 0.0048085550 0.1053356225 0.198601888 17 3937416 3937636 221 - 1.408 1.284 -0.434
ENSG00000074370 E026 28.7556725 0.0031661392 0.0079905578 0.023754625 17 3940971 3941306 336 - 1.546 1.369 -0.611
ENSG00000074370 E027 9.1644347 0.0032399724 0.1075564118 0.201929560 17 3941436 3941438 3 - 1.077 0.902 -0.646
ENSG00000074370 E028 17.9847234 0.0026707018 0.2614706690 0.399106067 17 3941439 3941654 216 - 1.294 1.202 -0.324
ENSG00000074370 E029 12.3416830 0.0148476461 0.1133915998 0.210466639 17 3942606 3942731 126 - 0.942 1.134 0.704
ENSG00000074370 E030 19.5976035 0.0056888026 0.1194952396 0.219227839 17 3943391 3943522 132 - 1.359 1.232 -0.443
ENSG00000074370 E031 12.8317870 0.0100900358 0.0807227156 0.160679551 17 3944704 3944806 103 - 1.217 1.042 -0.627
ENSG00000074370 E032 0.0000000       17 3945060 3945148 89 -      
ENSG00000074370 E033 0.0000000       17 3945149 3945376 228 -      
ENSG00000074370 E034 0.0000000       17 3947391 3947855 465 -      
ENSG00000074370 E035 0.0000000       17 3950511 3950596 86 -      
ENSG00000074370 E036 0.0000000       17 3950693 3950773 81 -      
ENSG00000074370 E037 0.0000000       17 3951251 3951389 139 -      
ENSG00000074370 E038 0.0000000       17 3951581 3951685 105 -      
ENSG00000074370 E039 0.0000000       17 3953281 3953346 66 -      
ENSG00000074370 E040 0.0000000       17 3953347 3953429 83 -      
ENSG00000074370 E041 0.0000000       17 3953693 3953710 18 -      
ENSG00000074370 E042 0.0000000       17 3964174 3964464 291 -