ENSG00000074219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311227 ENSG00000074219 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD2 protein_coding protein_coding 18.23578 32.92435 10.43128 1.09546 0.1365489 -1.657294 8.6028700 15.0490240 3.3279174 0.3934148 0.25387720 -2.1736081 0.45778750 0.45780000 0.31923333 -0.13856667 8.792128e-03 8.950546e-05 FALSE TRUE
ENST00000539846 ENSG00000074219 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD2 protein_coding protein_coding 18.23578 32.92435 10.43128 1.09546 0.1365489 -1.657294 0.6449215 0.6269636 0.7755561 0.5555963 0.22914481 0.3025033 0.04257917 0.01923333 0.07423333 0.05500000 1.964310e-01 8.950546e-05 FALSE TRUE
ENST00000593945 ENSG00000074219 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD2 protein_coding protein_coding 18.23578 32.92435 10.43128 1.09546 0.1365489 -1.657294 2.1817796 5.1489629 0.3918776 0.9592989 0.19668773 -3.6822531 0.09809167 0.15853333 0.03746667 -0.12106667 2.345156e-01 8.950546e-05 FALSE TRUE
ENST00000598810 ENSG00000074219 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD2 protein_coding protein_coding 18.23578 32.92435 10.43128 1.09546 0.1365489 -1.657294 1.2922943 1.8921097 2.6988055 0.6755663 0.12391233 0.5100564 0.08065833 0.05626667 0.25890000 0.20263333 8.950546e-05 8.950546e-05 FALSE TRUE
MSTRG.17492.5 ENSG00000074219 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD2 protein_coding   18.23578 32.92435 10.43128 1.09546 0.1365489 -1.657294 2.1253390 4.8059659 2.3120835 0.9422916 0.44315145 -1.0524053 0.12344583 0.14490000 0.22070000 0.07580000 4.248450e-01 8.950546e-05 FALSE TRUE
MSTRG.17492.7 ENSG00000074219 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD2 protein_coding   18.23578 32.92435 10.43128 1.09546 0.1365489 -1.657294 0.8841169 2.3870925 0.1322255 0.4343926 0.07265647 -4.0750340 0.03951250 0.07293333 0.01273333 -0.06020000 3.711823e-02 8.950546e-05 FALSE TRUE
MSTRG.17492.8 ENSG00000074219 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD2 protein_coding   18.23578 32.92435 10.43128 1.09546 0.1365489 -1.657294 1.3291521 2.2291244 0.3874869 0.3661076 0.33209029 -2.4939556 0.07670000 0.06713333 0.03786667 -0.02926667 4.279731e-01 8.950546e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000074219 E001 4.7917788 0.0278479317 3.713437e-01 0.5157797811 19 49340595 49340599 5 - 0.540 0.708 0.732
ENSG00000074219 E002 41.4961000 0.0140229081 1.374230e-01 0.2444931852 19 49340600 49340652 53 - 1.409 1.551 0.488
ENSG00000074219 E003 368.2580170 0.0055885581 2.165805e-02 0.0549646027 19 49340653 49341062 410 - 2.377 2.478 0.334
ENSG00000074219 E004 133.8870720 0.0073799808 2.944336e-01 0.4355372186 19 49341063 49341063 1 - 1.971 2.035 0.216
ENSG00000074219 E005 151.2733601 0.0067656995 1.415161e-01 0.2500960124 19 49341064 49341081 18 - 2.007 2.091 0.283
ENSG00000074219 E006 445.2100601 0.0005120684 5.110119e-02 0.1111338310 19 49341082 49341437 356 - 2.503 2.551 0.158
ENSG00000074219 E007 240.9932869 0.0007660170 2.348028e-01 0.3681305739 19 49342438 49342590 153 - 2.243 2.283 0.133
ENSG00000074219 E008 119.6962778 0.0002621348 2.232298e-01 0.3542458182 19 49343231 49343269 39 - 1.929 1.982 0.179
ENSG00000074219 E009 195.4676968 0.0002091521 3.560611e-01 0.5004549325 19 49343270 49343398 129 - 2.157 2.190 0.110
ENSG00000074219 E010 108.4203465 0.0002659106 4.762789e-01 0.6149279136 19 49347190 49347223 34 - 1.950 1.925 -0.085
ENSG00000074219 E011 78.6019550 0.0003219557 6.200905e-01 0.7373757483 19 49347224 49347232 9 - 1.810 1.790 -0.067
ENSG00000074219 E012 148.9749598 0.0002567931 9.731325e-01 0.9872348676 19 49347233 49347356 124 - 2.061 2.066 0.017
ENSG00000074219 E013 60.5108706 0.0008026323 8.265776e-01 0.8908901134 19 49347357 49347363 7 - 1.663 1.679 0.055
ENSG00000074219 E014 0.0000000       19 49347364 49347424 61 -      
ENSG00000074219 E015 105.8996269 0.0024928680 7.293814e-01 0.8215705113 19 49348703 49348845 143 - 1.899 1.920 0.071
ENSG00000074219 E016 1.2252587 0.0126478143 1.402578e-02 0.0382829283 19 49348957 49349059 103 - 0.611 0.180 -2.584
ENSG00000074219 E017 82.0775490 0.0013773540 9.243116e-01 0.9563207596 19 49351301 49351365 65 - 1.801 1.810 0.028
ENSG00000074219 E018 81.9107361 0.0004268943 7.344513e-01 0.8253917659 19 49355148 49355206 59 - 1.818 1.805 -0.042
ENSG00000074219 E019 13.5700099 0.0013486908 3.024941e-01 0.4443626884 19 49355303 49355311 9 - 1.145 1.040 -0.379
ENSG00000074219 E020 135.5705758 0.0009520635 2.145362e-02 0.0545459061 19 49355312 49355419 108 - 2.090 2.007 -0.280
ENSG00000074219 E021 28.5048357 0.0014978168 5.946554e-05 0.0003287873 19 49355959 49355970 12 - 1.580 1.295 -0.983
ENSG00000074219 E022 163.9944189 0.0056396224 6.789141e-03 0.0206745166 19 49357252 49357314 63 - 2.203 2.082 -0.406
ENSG00000074219 E023 1.3726069 0.0323865779 8.959041e-02 0.1745006798 19 49359305 49359434 130 - 0.540 0.228 -1.841
ENSG00000074219 E024 162.7798704 0.0030657263 2.219189e-03 0.0079034970 19 49359435 49359499 65 - 2.198 2.078 -0.400
ENSG00000074219 E025 150.8322370 0.0037628590 7.815679e-02 0.1565044096 19 49359844 49360081 238 - 2.132 2.058 -0.248
ENSG00000074219 E026 4.0482428 0.0049471957 2.417956e-04 0.0011409361 19 49360082 49360438 357 - 0.984 0.461 -2.192
ENSG00000074219 E027 2.1766314 0.0071602805 4.438753e-03 0.0143683640 19 49361396 49361495 100 - 0.773 0.307 -2.261
ENSG00000074219 E028 0.6986918 0.0167035135 8.702112e-01 0.9205160809 19 49362329 49362332 4 - 0.209 0.181 -0.259
ENSG00000074219 E029 4.7414551 0.0039293758 3.286661e-01 0.4721501877 19 49362333 49362372 40 - 0.540 0.709 0.739
ENSG00000074219 E030 25.5079167 0.0216610283 1.075732e-01 0.2019544092 19 49362373 49362457 85 - 1.440 1.281 -0.551