ENSG00000074211

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382599 ENSG00000074211 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R2C protein_coding protein_coding 3.163219 5.200085 2.492605 0.1688287 0.1267464 -1.057876 1.870620 2.045365 1.9587610 0.1797506 0.1042755 -0.06210648 0.6585583 0.3932333 0.7929000 0.3996667 0.01250305 0.01250305 FALSE TRUE
ENST00000506140 ENSG00000074211 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R2C protein_coding protein_coding 3.163219 5.200085 2.492605 0.1688287 0.1267464 -1.057876 1.142614 2.862015 0.4185803 0.1636074 0.2453844 -2.74442581 0.2977708 0.5497333 0.1589333 -0.3908000 0.15110926 0.01250305 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000074211 E001 0.0000000       4 6320578 6320580 3 -      
ENSG00000074211 E002 132.2812307 0.0089683362 3.614263e-06 2.657628e-05 4 6320581 6322943 2363 - 2.237 2.003 -0.785
ENSG00000074211 E003 11.2491518 0.0223722943 2.356736e-03 8.328853e-03 4 6322944 6323045 102 - 1.275 0.893 -1.388
ENSG00000074211 E004 17.3229180 0.0012441767 7.570376e-02 1.526281e-01 4 6323046 6323160 115 - 1.336 1.162 -0.611
ENSG00000074211 E005 70.2010763 0.0003872356 7.963689e-02 1.589759e-01 4 6323161 6323593 433 - 1.776 1.825 0.165
ENSG00000074211 E006 34.7344360 0.0006849362 3.243069e-02 7.668655e-02 4 6329262 6329353 92 - 1.429 1.539 0.379
ENSG00000074211 E007 35.1141903 0.0087067064 1.612455e-01 2.767120e-01 4 6333562 6333645 84 - 1.451 1.530 0.272
ENSG00000074211 E008 30.3989751 0.0009067810 3.122814e-01 4.548240e-01 4 6333646 6333731 86 - 1.421 1.462 0.141
ENSG00000074211 E009 1.0726966 0.0121989077 3.501858e-01 4.943896e-01 4 6347190 6347373 184 - 0.167 0.328 1.264
ENSG00000074211 E010 29.2146308 0.0009028268 3.312736e-01 4.748734e-01 4 6347846 6347925 80 - 1.405 1.445 0.136
ENSG00000074211 E011 36.7387689 0.0228127773 5.770480e-01 7.023741e-01 4 6347926 6348010 85 - 1.523 1.544 0.071
ENSG00000074211 E012 37.3196616 0.0007292920 4.664508e-03 1.499664e-02 4 6372523 6372591 69 - 1.429 1.579 0.517
ENSG00000074211 E013 43.7543859 0.0039283391 8.820054e-03 2.583264e-02 4 6372592 6372700 109 - 1.505 1.644 0.474
ENSG00000074211 E014 43.3618910 0.0005537203 4.424505e-01 5.840609e-01 4 6375819 6375931 113 - 1.592 1.607 0.052
ENSG00000074211 E015 36.9698517 0.0219530962 7.339645e-01 8.250601e-01 4 6378407 6378572 166 - 1.531 1.532 0.006
ENSG00000074211 E016 1.0308674 0.0147962470 4.239296e-01 5.669604e-01 4 6380033 6380390 358 - 0.382 0.225 -1.057
ENSG00000074211 E017 20.2329805 0.0009655496 9.027203e-01 9.420591e-01 4 6380997 6381040 44 - 1.296 1.280 -0.059
ENSG00000074211 E018 18.3841696 0.0011069953 3.482514e-01 4.924735e-01 4 6381041 6381094 54 - 1.205 1.259 0.189
ENSG00000074211 E019 0.5546650 0.0212923606 1.000000e+00 1.000000e+00 4 6381095 6381776 682 - 0.167 0.162 -0.057
ENSG00000074211 E020 0.4782907 0.0213000651 2.468027e-01 3.821896e-01 4 6381777 6384826 3050 - 0.000 0.224 11.310
ENSG00000074211 E021 0.0000000       4 6413903 6414031 129 -      
ENSG00000074211 E022 0.0000000       4 6420946 6421118 173 -      
ENSG00000074211 E023 0.0000000       4 6471564 6471686 123 -      
ENSG00000074211 E024 17.9027464 0.0014983555 9.063180e-01 9.444817e-01 4 6472160 6472614 455 - 1.242 1.225 -0.058
ENSG00000074211 E025 0.0000000       4 6523443 6523547 105 -      
ENSG00000074211 E026 0.1451727 0.0425278328 2.546541e-01   4 6535271 6535377 107 - 0.167 0.000 -12.121
ENSG00000074211 E027 0.0000000       4 6555534 6555678 145 -      
ENSG00000074211 E028 0.1451727 0.0425278328 2.546541e-01   4 6563560 6563600 41 - 0.167 0.000 -12.121