ENSG00000074201

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263309 ENSG00000074201 HEK293_OSMI2_2hA HEK293_TMG_2hB CLNS1A protein_coding protein_coding 129.22 112.4761 170.8474 13.45144 2.856587 0.6030467 10.125668 15.6535700 10.63439 4.5367532 1.583223 -0.5573195 0.07976667 0.133933333 0.0626000 -0.07133333 0.02991436 2.209629e-20 FALSE TRUE
ENST00000528364 ENSG00000074201 HEK293_OSMI2_2hA HEK293_TMG_2hB CLNS1A protein_coding protein_coding 129.22 112.4761 170.8474 13.45144 2.856587 0.6030467 9.413932 0.5602666 18.45070 0.5602666 3.998786 5.0166767 0.06112083 0.005566667 0.1088000 0.10323333 0.02245348 2.209629e-20 FALSE TRUE
MSTRG.6035.3 ENSG00000074201 HEK293_OSMI2_2hA HEK293_TMG_2hB CLNS1A protein_coding   129.22 112.4761 170.8474 13.45144 2.856587 0.6030467 95.196488 85.1756953 121.07608 8.0436412 6.265429 0.5073500 0.74788750 0.761500000 0.7079333 -0.05356667 0.45959005 2.209629e-20 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000074201 E001 0.5891098 0.0182800678 5.795476e-02 1.231284e-01 11 77514936 77514962 27 - 0.337 0.000 -10.840
ENSG00000074201 E002 0.5933762 0.0223467051 5.871797e-02 1.244338e-01 11 77529948 77530014 67 - 0.337 0.000 -12.618
ENSG00000074201 E003 0.9576903 0.8451229074 6.719522e-01 7.780799e-01 11 77585362 77585459 98 - 0.392 0.140 -1.951
ENSG00000074201 E004 3.1504438 0.0073886267 1.690689e-01 2.869778e-01 11 77611315 77611374 60 - 0.709 0.500 -0.927
ENSG00000074201 E005 0.2934659 0.0282967847 8.977792e-01   11 77612231 77612235 5 - 0.112 0.134 0.293
ENSG00000074201 E006 1.4048617 0.0096375578 1.529575e-01 2.656887e-01 11 77612236 77612297 62 - 0.485 0.236 -1.512
ENSG00000074201 E007 2.6301059 0.0362299932 5.755593e-01 7.011457e-01 11 77612298 77612370 73 - 0.595 0.501 -0.437
ENSG00000074201 E008 2.3345637 0.0509804123 5.374911e-01 6.690500e-01 11 77612371 77612430 60 - 0.562 0.450 -0.542
ENSG00000074201 E009 1.8822075 0.0090898253 9.899497e-01 9.978239e-01 11 77612431 77612517 87 - 0.441 0.448 0.035
ENSG00000074201 E010 1.6575546 0.0099434434 5.463697e-01 6.765633e-01 11 77612960 77613041 82 - 0.485 0.387 -0.514
ENSG00000074201 E011 2.8950829 0.0836298009 2.993403e-02 7.183007e-02 11 77614530 77615061 532 - 0.755 0.319 -2.112
ENSG00000074201 E012 79.6513071 0.0003379608 9.778873e-14 2.784576e-12 11 77615062 77616194 1133 - 1.734 2.043 1.042
ENSG00000074201 E013 81.6870561 0.0003285142 1.301655e-14 4.214573e-13 11 77616195 77616205 11 - 1.741 2.057 1.065
ENSG00000074201 E014 263.8563368 0.0011280706 1.957109e-22 1.637670e-20 11 77616206 77616249 44 - 2.272 2.547 0.917
ENSG00000074201 E015 950.1139573 0.0006956776 1.418178e-25 1.648279e-23 11 77616250 77616403 154 - 2.885 3.064 0.595
ENSG00000074201 E016 1914.2308253 0.0005794270 6.778196e-16 2.619561e-14 11 77616404 77616695 292 - 3.229 3.336 0.353
ENSG00000074201 E017 6.0194228 0.0094135974 8.243249e-01 8.893172e-01 11 77618486 77618532 47 - 0.856 0.831 -0.096
ENSG00000074201 E018 13.1448081 0.0086822172 5.617263e-02 1.200056e-01 11 77618533 77618687 155 - 1.235 1.045 -0.679
ENSG00000074201 E019 3.9265446 0.0099198993 2.758751e-03 9.548562e-03 11 77619484 77619605 122 - 0.856 0.388 -2.095
ENSG00000074201 E020 1171.8993077 0.0001202537 1.776121e-02 4.662399e-02 11 77619606 77619695 90 - 3.057 3.091 0.114
ENSG00000074201 E021 5.5930778 0.0054762162 9.017872e-01 9.414121e-01 11 77621454 77621589 136 - 0.818 0.807 -0.044
ENSG00000074201 E022 6.1112998 0.0446115468 5.314259e-01 6.638864e-01 11 77621590 77621640 51 - 0.889 0.787 -0.399
ENSG00000074201 E023 1.1102750 0.0165310693 5.435016e-01 6.740995e-01 11 77621866 77622044 179 - 0.274 0.387 0.708
ENSG00000074201 E024 2.1486180 0.0080458481 9.535877e-01 9.749321e-01 11 77622460 77622499 40 - 0.485 0.500 0.073
ENSG00000074201 E025 1388.2265069 0.0001093163 2.047836e-04 9.844763e-04 11 77622500 77622642 143 - 3.161 3.133 -0.096
ENSG00000074201 E026 850.9413948 0.0005446408 3.784754e-06 2.769342e-05 11 77622643 77622673 31 - 2.965 2.896 -0.229
ENSG00000074201 E027 4.7683422 0.0283925506 7.474242e-01 8.349339e-01 11 77622674 77622674 1 - 0.778 0.728 -0.202
ENSG00000074201 E028 1215.8056372 0.0000995919 1.871307e-14 5.918423e-13 11 77624963 77625070 108 - 3.123 3.050 -0.243
ENSG00000074201 E029 1.7766910 0.0078047400 1.471266e-01 2.577846e-01 11 77625071 77625551 481 - 0.562 0.318 -1.292
ENSG00000074201 E030 1172.6507355 0.0002692075 6.855768e-11 1.244185e-09 11 77625717 77625815 99 - 3.108 3.033 -0.249
ENSG00000074201 E031 512.5827165 0.0002790887 1.086005e-08 1.330018e-07 11 77625816 77625818 3 - 2.756 2.664 -0.305
ENSG00000074201 E032 1118.2145778 0.0007436213 8.977673e-06 6.033963e-05 11 77629763 77629899 137 - 3.084 3.015 -0.229
ENSG00000074201 E033 748.4426485 0.0020327196 1.986330e-03 7.183709e-03 11 77637590 77637860 271 - 2.912 2.837 -0.250