ENSG00000073969

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398238 ENSG00000073969 HEK293_OSMI2_2hA HEK293_TMG_2hB NSF protein_coding protein_coding 28.2239 20.51511 36.97634 2.012779 1.165931 0.8496027 26.15466 16.611178 36.0929469 1.712899 1.0161417 1.119094 0.90971667 0.8139333 0.9764667 0.1625333 0.0087312271 0.0002349231 FALSE TRUE
ENST00000465370 ENSG00000073969 HEK293_OSMI2_2hA HEK293_TMG_2hB NSF protein_coding protein_coding 28.2239 20.51511 36.97634 2.012779 1.165931 0.8496027 1.77358 3.903933 0.3173228 1.598300 0.1238127 -3.579833 0.08231667 0.1860667 0.0087000 -0.1773667 0.0002349231 0.0002349231 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000073969 E001 0.0000000       17 46590669 46590754 86 +      
ENSG00000073969 E002 0.0000000       17 46590755 46590759 5 +      
ENSG00000073969 E003 0.0000000       17 46590760 46590787 28 +      
ENSG00000073969 E004 0.0000000       17 46591021 46591247 227 +      
ENSG00000073969 E005 0.0000000       17 46602442 46602523 82 +      
ENSG00000073969 E006 0.0000000       17 46624036 46624243 208 +      
ENSG00000073969 E007 0.0000000       17 46624244 46624329 86 +      
ENSG00000073969 E008 0.3030308 0.3803324972 4.571037e-01   17 46626613 46626712 100 + 0.173 0.000 -9.675
ENSG00000073969 E009 0.0000000       17 46630411 46630450 40 +      
ENSG00000073969 E010 0.0000000       17 46630451 46630643 193 +      
ENSG00000073969 E011 0.3030308 0.3803324972 4.571037e-01   17 46637376 46637542 167 + 0.173 0.000 -11.463
ENSG00000073969 E012 0.0000000       17 46640054 46640161 108 +      
ENSG00000073969 E013 0.0000000       17 46640643 46640718 76 +      
ENSG00000073969 E014 0.0000000       17 46643104 46643259 156 +      
ENSG00000073969 E015 0.1472490 0.0442410873 7.283098e-01   17 46674414 46674613 200 + 0.095 0.000 -11.648
ENSG00000073969 E016 75.9241003 0.0125470263 5.773955e-03 1.801865e-02 17 46692903 46693068 166 + 1.923 1.802 -0.408
ENSG00000073969 E017 59.9628786 0.0087535288 1.851099e-02 4.825456e-02 17 46693847 46693921 75 + 1.810 1.723 -0.291
ENSG00000073969 E018 46.3882870 0.0037826877 3.006307e-02 7.207672e-02 17 46694475 46694662 188 + 1.694 1.631 -0.213
ENSG00000073969 E019 82.8563274 0.0003366761 1.354287e-02 3.718019e-02 17 46704759 46704854 96 + 1.929 1.902 -0.092
ENSG00000073969 E020 152.8517797 0.0002380240 1.968128e-03 7.126317e-03 17 46710963 46711119 157 + 2.190 2.170 -0.064
ENSG00000073969 E021 0.4460135 0.0347445879 1.758057e-01 2.957288e-01 17 46713149 46713361 213 + 0.238 0.000 -13.293
ENSG00000073969 E022 191.1240852 0.0002593102 3.751449e-05 2.177459e-04 17 46713853 46713986 134 + 2.291 2.253 -0.127
ENSG00000073969 E023 100.5754855 0.0017177901 7.085011e-02 1.447605e-01 17 46726549 46726555 7 + 2.000 1.995 -0.016
ENSG00000073969 E024 165.5467887 0.0006665609 1.748654e-05 1.098983e-04 17 46726556 46726615 60 + 2.236 2.177 -0.198
ENSG00000073969 E025 200.5681326 0.0010432822 3.101286e-06 2.312470e-05 17 46728855 46728934 80 + 2.322 2.255 -0.225
ENSG00000073969 E026 241.3996581 0.0002655302 1.377599e-06 1.109995e-05 17 46749773 46749907 135 + 2.394 2.351 -0.144
ENSG00000073969 E027 212.4607067 0.0001932775 1.191612e-03 4.612635e-03 17 46751503 46751616 114 + 2.328 2.319 -0.029
ENSG00000073969 E028 143.3191153 0.0009328688 7.610355e-01 8.449820e-01 17 46755314 46755369 56 + 2.121 2.201 0.266
ENSG00000073969 E029 2.9744879 0.0459452948 8.324064e-01 8.949982e-01 17 46755499 46755597 99 + 0.593 0.606 0.059
ENSG00000073969 E030 1277.2645602 0.0036641008 1.424112e-11 2.891370e-10 17 46755802 46757464 1663 + 3.011 3.204 0.641