ENSG00000073921

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393346 ENSG00000073921 HEK293_OSMI2_2hA HEK293_TMG_2hB PICALM protein_coding protein_coding 35.15825 16.37085 56.39174 0.3009282 2.187952 1.783729 2.8278430 3.2873239 4.357164 0.3800520 0.2798280 0.405401 0.10223333 0.20010000 0.07710000 -0.12300000 2.077849e-08 4.866204e-23 FALSE TRUE
ENST00000526033 ENSG00000073921 HEK293_OSMI2_2hA HEK293_TMG_2hB PICALM protein_coding protein_coding 35.15825 16.37085 56.39174 0.3009282 2.187952 1.783729 8.1594430 3.2490733 11.791775 0.4456280 0.4451502 1.856470 0.23781667 0.19906667 0.21036667 0.01130000 9.056906e-01 4.866204e-23 FALSE TRUE
ENST00000529760 ENSG00000073921 HEK293_OSMI2_2hA HEK293_TMG_2hB PICALM protein_coding protein_coding 35.15825 16.37085 56.39174 0.3009282 2.187952 1.783729 0.2763819 0.9213214 0.000000 0.1892492 0.0000000 -6.541207 0.01744583 0.05630000 0.00000000 -0.05630000 1.827491e-16 4.866204e-23 FALSE TRUE
ENST00000530542 ENSG00000073921 HEK293_OSMI2_2hA HEK293_TMG_2hB PICALM protein_coding protein_coding 35.15825 16.37085 56.39174 0.3009282 2.187952 1.783729 2.7404400 0.5290913 5.498373 0.2650045 0.5196166 3.353025 0.06519583 0.03286667 0.09713333 0.06426667 4.085127e-01 4.866204e-23 FALSE FALSE
ENST00000532317 ENSG00000073921 HEK293_OSMI2_2hA HEK293_TMG_2hB PICALM protein_coding protein_coding 35.15825 16.37085 56.39174 0.3009282 2.187952 1.783729 9.9210803 6.0864560 15.852679 0.1709108 1.3994663 1.379594 0.30440417 0.37190000 0.28023333 -0.09166667 3.822409e-02 4.866204e-23 FALSE TRUE
ENST00000532603 ENSG00000073921 HEK293_OSMI2_2hA HEK293_TMG_2hB PICALM protein_coding protein_coding 35.15825 16.37085 56.39174 0.3009282 2.187952 1.783729 3.4853047 1.2649208 5.443789 0.3166123 0.2360095 2.096851 0.09226250 0.07666667 0.09716667 0.02050000 6.656622e-01 4.866204e-23 FALSE FALSE
MSTRG.6128.17 ENSG00000073921 HEK293_OSMI2_2hA HEK293_TMG_2hB PICALM protein_coding   35.15825 16.37085 56.39174 0.3009282 2.187952 1.783729 2.8188829 0.0000000 5.755150 0.0000000 0.7085765 9.171214 0.05357917 0.00000000 0.10140000 0.10140000 4.866204e-23 4.866204e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000073921 E001 35.6206587 0.0074968310 3.012145e-08 3.389012e-07 11 85957175 85957683 509 - 1.359 1.780 1.439
ENSG00000073921 E002 17.6857393 0.0072474061 5.641266e-10 8.758571e-09 11 85957684 85957687 4 - 0.984 1.558 2.027
ENSG00000073921 E003 661.6285559 0.0046325679 9.268751e-21 6.501063e-19 11 85957688 85958626 939 - 2.653 2.990 1.122
ENSG00000073921 E004 230.9140452 0.0004845918 6.581268e-05 3.599335e-04 11 85958627 85958754 128 - 2.285 2.414 0.431
ENSG00000073921 E005 198.7739361 0.0001824108 3.325300e-04 1.510507e-03 11 85958755 85958810 56 - 2.222 2.342 0.402
ENSG00000073921 E006 126.7694537 0.0002292949 6.168196e-03 1.905497e-02 11 85958811 85958816 6 - 2.029 2.145 0.388
ENSG00000073921 E007 110.9246555 0.0002432027 5.661732e-03 1.771894e-02 11 85958817 85958817 1 - 1.969 2.092 0.412
ENSG00000073921 E008 135.2159036 0.0002354244 7.920304e-05 4.241034e-04 11 85958818 85958838 21 - 2.044 2.195 0.507
ENSG00000073921 E009 179.3016346 0.0002403440 2.003577e-03 7.237243e-03 11 85958839 85958882 44 - 2.181 2.293 0.374
ENSG00000073921 E010 231.3494417 0.0020439437 1.195865e-02 3.343092e-02 11 85958883 85958986 104 - 2.293 2.399 0.353
ENSG00000073921 E011 139.8410576 0.0009892694 1.335494e-02 3.674680e-02 11 85958987 85959022 36 - 2.073 2.183 0.368
ENSG00000073921 E012 106.4077290 0.0012542338 6.231636e-01 7.397996e-01 11 85959023 85959036 14 - 1.976 2.019 0.146
ENSG00000073921 E013 111.6586673 0.0028522172 4.361132e-01 5.782459e-01 11 85959037 85959060 24 - 1.992 2.051 0.196
ENSG00000073921 E014 2.4012738 0.0167409145 9.925982e-01 9.994672e-01 11 85960675 85960777 103 - 0.493 0.507 0.070
ENSG00000073921 E015 200.0373685 0.0015293870 5.172666e-01 6.516812e-01 11 85974708 85974781 74 - 2.248 2.293 0.150
ENSG00000073921 E016 154.4562468 0.0002117791 9.655722e-01 9.823679e-01 11 85974782 85974812 31 - 2.145 2.167 0.074
ENSG00000073921 E017 117.3341730 0.0029854938 7.966610e-01 8.702260e-01 11 85976623 85976648 26 - 2.021 2.055 0.115
ENSG00000073921 E018 121.6492262 0.0053301632 7.701062e-01 8.515526e-01 11 85976649 85976682 34 - 2.044 2.052 0.027
ENSG00000073921 E019 7.6586071 0.0022337288 7.171091e-01 8.125881e-01 11 85976683 85977005 323 - 0.876 0.941 0.248
ENSG00000073921 E020 23.1226956 0.0072744102 6.651264e-01 7.728309e-01 11 85978070 85978093 24 - 1.325 1.384 0.205
ENSG00000073921 E021 8.6705561 0.0060432544 8.078420e-03 2.397857e-02 11 85978094 85978715 622 - 1.032 0.687 -1.339
ENSG00000073921 E022 148.2541953 0.0010055828 5.128494e-01 6.477358e-01 11 85981129 85981183 55 - 2.120 2.167 0.155
ENSG00000073921 E023 174.8680877 0.0002019450 2.656434e-01 4.037115e-01 11 85981184 85981228 45 - 2.210 2.200 -0.032
ENSG00000073921 E024 167.0617608 0.0004438558 4.780001e-02 1.052655e-01 11 85981745 85981775 31 - 2.198 2.159 -0.132
ENSG00000073921 E025 250.6266838 0.0001913304 9.829705e-02 1.879291e-01 11 85981872 85981988 117 - 2.368 2.349 -0.060
ENSG00000073921 E026 79.5879943 0.0021263299 1.408211e-01 2.491503e-01 11 85981989 85982003 15 - 1.882 1.832 -0.169
ENSG00000073921 E027 0.4449813 0.0213862000 7.957853e-01 8.696061e-01 11 85982004 85982185 182 - 0.141 0.191 0.525
ENSG00000073921 E028 212.8386115 0.0019035159 3.755086e-01 5.199378e-01 11 85983866 85983973 108 - 2.294 2.287 -0.024
ENSG00000073921 E029 100.7818974 0.0005296084 4.868369e-01 6.245541e-01 11 85990250 85990378 129 - 1.969 1.965 -0.016
ENSG00000073921 E030 44.4646026 0.0005070367 2.490301e-01 3.847721e-01 11 85990379 85990399 21 - 1.631 1.586 -0.153
ENSG00000073921 E031 192.9535362 0.0011569358 7.513502e-02 1.517495e-01 11 85996826 85996929 104 - 2.258 2.224 -0.117
ENSG00000073921 E032 133.0493965 0.0014560175 2.603828e-03 9.076124e-03 11 86000643 86000680 38 - 2.114 2.019 -0.319
ENSG00000073921 E033 171.2191864 0.0035237967 3.867428e-02 8.857903e-02 11 86000681 86000779 99 - 2.215 2.150 -0.215
ENSG00000073921 E034 0.0000000       11 86001031 86001034 4 -      
ENSG00000073921 E035 187.8006157 0.0011273142 1.594294e-02 4.260423e-02 11 86001035 86001158 124 - 2.251 2.194 -0.189
ENSG00000073921 E036 150.1474852 0.0002451474 1.024285e-03 4.042240e-03 11 86003366 86003451 86 - 2.162 2.077 -0.287
ENSG00000073921 E037 0.4762024 0.2921056725 7.781131e-01 8.572262e-01 11 86003452 86003778 327 - 0.141 0.192 0.533
ENSG00000073921 E038 1.1813256 0.0890139968 9.149305e-01 9.501328e-01 11 86007369 86007541 173 - 0.292 0.326 0.224
ENSG00000073921 E039 118.6262310 0.0002628053 1.760588e-02 4.628424e-02 11 86007542 86007583 42 - 2.057 1.992 -0.215
ENSG00000073921 E040 136.7654616 0.0002365120 7.377680e-02 1.495622e-01 11 86011030 86011111 82 - 2.110 2.072 -0.126
ENSG00000073921 E041 73.7932664 0.0004435903 1.802389e-01 3.014834e-01 11 86011112 86011136 25 - 1.845 1.806 -0.131
ENSG00000073921 E042 124.4857141 0.0003153461 7.957319e-03 2.366770e-02 11 86012281 86012328 48 - 2.078 2.004 -0.246
ENSG00000073921 E043 105.8818440 0.0040271047 1.741037e-02 4.584513e-02 11 86012329 86012342 14 - 2.014 1.917 -0.327
ENSG00000073921 E044 139.2027184 0.0046822231 1.298070e-03 4.970098e-03 11 86012343 86012392 50 - 2.141 2.006 -0.453
ENSG00000073921 E045 192.6661292 0.0018290007 9.350628e-06 6.257103e-05 11 86014870 86014963 94 - 2.282 2.144 -0.461
ENSG00000073921 E046 111.6136237 0.0002853813 1.034477e-03 4.077823e-03 11 86022367 86022377 11 - 2.041 1.938 -0.346
ENSG00000073921 E047 190.4054060 0.0008105299 8.408491e-06 5.682863e-05 11 86022378 86022469 92 - 2.274 2.154 -0.404
ENSG00000073921 E048 1.0287806 0.0121801444 7.388104e-02 1.497149e-01 11 86023416 86023541 126 - 0.369 0.000 -11.503
ENSG00000073921 E049 159.4854200 0.0014041696 5.871526e-08 6.234058e-07 11 86026292 86026367 76 - 2.211 2.030 -0.606
ENSG00000073921 E050 195.3412275 0.0029890565 3.018062e-09 4.091619e-08 11 86031469 86031611 143 - 2.306 2.089 -0.723
ENSG00000073921 E051 147.4949497 0.0002759579 2.910272e-14 8.938752e-13 11 86068651 86068733 83 - 2.190 1.941 -0.836
ENSG00000073921 E052 85.8308140 0.0010714607 4.262220e-05 2.441389e-04 11 86068734 86068738 5 - 1.941 1.771 -0.571
ENSG00000073921 E053 156.2144518 0.0044494572 5.573642e-06 3.924440e-05 11 86068739 86069022 284 - 2.204 2.013 -0.639
ENSG00000073921 E054 48.7775567 0.0040106458 1.345233e-03 5.127156e-03 11 86069023 86069097 75 - 1.704 1.513 -0.654
ENSG00000073921 E055 0.1451727 0.0432137605 1.000000e+00   11 86069246 86069457 212 - 0.076 0.000 -8.695
ENSG00000073921 E056 0.0000000       11 86069458 86069719 262 -      
ENSG00000073921 E057 0.8104413 0.7292895099 1.000000e+00 1.000000e+00 11 86069720 86069915 196 - 0.247 0.198 -0.406