ENSG00000073792

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346192 ENSG00000073792 HEK293_OSMI2_2hA HEK293_TMG_2hB IGF2BP2 protein_coding protein_coding 17.76616 15.23014 21.24774 1.039939 0.5461276 0.480112 7.706986 6.0683920 8.220323 0.79014664 0.4740769 0.4372593 0.4326625 0.3957 0.38623333 -0.009466667 9.617948e-01 2.336178e-22 FALSE TRUE
ENST00000382199 ENSG00000073792 HEK293_OSMI2_2hA HEK293_TMG_2hB IGF2BP2 protein_coding protein_coding 17.76616 15.23014 21.24774 1.039939 0.5461276 0.480112 4.582718 7.4748212 2.945736 0.44842276 0.3868681 -1.3404504 0.2744708 0.4973 0.13836667 -0.358933333 2.014870e-07 2.336178e-22 FALSE TRUE
ENST00000464166 ENSG00000073792 HEK293_OSMI2_2hA HEK293_TMG_2hB IGF2BP2 protein_coding processed_transcript 17.76616 15.23014 21.24774 1.039939 0.5461276 0.480112 1.217995 0.3361273 1.809701 0.08296862 0.5119880 2.3943268 0.0694500 0.0227 0.08403333 0.061333333 5.479788e-02 2.336178e-22 FALSE FALSE
MSTRG.24217.1 ENSG00000073792 HEK293_OSMI2_2hA HEK293_TMG_2hB IGF2BP2 protein_coding   17.76616 15.23014 21.24774 1.039939 0.5461276 0.480112 2.873708 0.0000000 6.163851 0.00000000 0.8254405 9.2700267 0.1435833 0.0000 0.29200000 0.292000000 2.336178e-22 2.336178e-22 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000073792 E001 4.6136202 0.0037911236 8.293290e-02 1.641408e-01 3 185639574 185639627 54 - 0.842 0.641 -0.818
ENSG00000073792 E002 123.4420081 0.0130233607 1.600427e-11 3.221721e-10 3 185643130 185643974 845 - 1.776 2.261 1.629
ENSG00000073792 E003 232.0294098 0.0089775112 6.211382e-22 4.907121e-20 3 185643975 185644248 274 - 2.004 2.545 1.809
ENSG00000073792 E004 257.6466660 0.0056705058 2.792451e-14 8.594986e-13 3 185644249 185644587 339 - 2.184 2.546 1.208
ENSG00000073792 E005 275.3870600 0.0027370723 2.247707e-05 1.377439e-04 3 185644588 185645200 613 - 2.337 2.516 0.596
ENSG00000073792 E006 115.2412450 0.0002624150 1.789765e-01 2.998643e-01 3 185645201 185645341 141 - 2.014 2.103 0.298
ENSG00000073792 E007 144.5827468 0.0002227913 1.998321e-01 3.260313e-01 3 185645342 185645500 159 - 2.116 2.198 0.276
ENSG00000073792 E008 159.6849651 0.0002101483 1.434306e-03 5.420838e-03 3 185645501 185645623 123 - 2.226 2.183 -0.146
ENSG00000073792 E009 5.9078427 0.0028526181 2.071490e-04 9.945957e-04 3 185646880 185647024 145 - 1.017 0.569 -1.799
ENSG00000073792 E010 155.3506496 0.0002255459 8.327359e-04 3.375831e-03 3 185647025 185647138 114 - 2.219 2.170 -0.164
ENSG00000073792 E011 141.2107250 0.0020440150 8.643979e-04 3.488806e-03 3 185649403 185649534 132 - 2.188 2.115 -0.246
ENSG00000073792 E012 99.9194863 0.0003369861 6.390548e-04 2.676697e-03 3 185652094 185652168 75 - 2.038 1.962 -0.256
ENSG00000073792 E013 111.6686310 0.0043929359 3.167639e-03 1.076026e-02 3 185657286 185657402 117 - 2.092 2.003 -0.298
ENSG00000073792 E014 74.3623943 0.0034191382 3.310057e-03 1.117671e-02 3 185658341 185658409 69 - 1.923 1.824 -0.333
ENSG00000073792 E015 61.1183138 0.0004039320 2.969935e-01 4.382860e-01 3 185672541 185672669 129 - 1.791 1.789 -0.008
ENSG00000073792 E016 0.3268771 0.0294856392 9.840635e-01   3 185675016 185675295 280 - 0.118 0.126 0.108
ENSG00000073792 E017 122.4773454 0.0002482551 2.406751e-03 8.482350e-03 3 185675296 185675431 136 - 2.118 2.066 -0.172
ENSG00000073792 E018 132.3006797 0.0002895242 2.663531e-03 9.263268e-03 3 185675791 185675913 123 - 2.148 2.100 -0.159
ENSG00000073792 E019 116.3981569 0.0002530586 2.259168e-03 8.027772e-03 3 185687057 185687191 135 - 2.096 2.042 -0.183
ENSG00000073792 E020 0.0000000       3 185689108 185689354 247 -      
ENSG00000073792 E021 88.2115944 0.0005510840 2.263179e-06 1.739644e-05 3 185689355 185689454 100 - 2.014 1.877 -0.459
ENSG00000073792 E022 86.2541269 0.0009469927 4.941811e-05 2.788086e-04 3 185689455 185689554 100 - 1.995 1.877 -0.394
ENSG00000073792 E023 93.5526482 0.0043765370 3.428637e-04 1.551523e-03 3 185689555 185689627 73 - 2.033 1.908 -0.420
ENSG00000073792 E024 93.9360185 0.0127084395 2.898862e-02 6.998250e-02 3 185692699 185692762 64 - 2.020 1.928 -0.307
ENSG00000073792 E025 3.6721472 0.0838391810 7.124541e-01 8.091913e-01 3 185692763 185692780 18 - 0.678 0.646 -0.132
ENSG00000073792 E026 5.8431202 0.0027373727 1.075449e-02 3.057882e-02 3 185693177 185693228 52 - 0.962 0.674 -1.134
ENSG00000073792 E027 0.4439371 0.0215533613 7.974700e-02 1.591621e-01 3 185696415 185696611 197 - 0.288 0.000 -10.780
ENSG00000073792 E028 86.2227765 0.0017653459 2.879412e-05 1.720427e-04 3 185696612 185696663 52 - 2.002 1.870 -0.443
ENSG00000073792 E029 81.5038965 0.0011412075 9.354032e-07 7.808987e-06 3 185698299 185698347 49 - 1.992 1.834 -0.531
ENSG00000073792 E030 0.0000000       3 185814055 185814100 46 -      
ENSG00000073792 E031 0.7300267 0.0283566126 3.286769e-01 4.721518e-01 3 185821012 185821131 120 - 0.118 0.305 1.697
ENSG00000073792 E032 83.5719722 0.0059076767 5.389080e-07 4.736684e-06 3 185823153 185823213 61 - 2.029 1.808 -0.742
ENSG00000073792 E033 1.6210189 0.0085708129 9.786324e-02 1.872565e-01 3 185823214 185823271 58 - 0.211 0.527 1.916
ENSG00000073792 E034 2.5067282 0.0058327242 4.775388e-01 6.160759e-01 3 185823712 185823850 139 - 0.460 0.606 0.692
ENSG00000073792 E035 108.8958823 0.0065738361 1.742789e-06 1.373689e-05 3 185824783 185825042 260 - 2.133 1.934 -0.666