ENSG00000073712

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341590 ENSG00000073712 HEK293_OSMI2_2hA HEK293_TMG_2hB FERMT2 protein_coding protein_coding 17.2809 5.414095 29.87682 0.1600586 1.055903 2.462055 13.312705 4.828371 23.28555 0.1607693 0.8527992 2.267461 0.79185000 0.8935 0.7795667 -0.1139333 1.507319e-01 2.352218e-18 FALSE TRUE
ENST00000553373 ENSG00000073712 HEK293_OSMI2_2hA HEK293_TMG_2hB FERMT2 protein_coding protein_coding 17.2809 5.414095 29.87682 0.1600586 1.055903 2.462055 2.658018 0.000000 4.43170 0.0000000 0.3821466 8.794968 0.09011667 0.0000 0.1478000 0.1478000 2.352218e-18 2.352218e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000073712 E001 0.0000000       14 52857268 52857270 3 -      
ENSG00000073712 E002 0.0000000       14 52857271 52857271 1 -      
ENSG00000073712 E003 0.0000000       14 52857272 52857272 1 -      
ENSG00000073712 E004 0.1817044 0.0412622447 8.137987e-02   14 52857273 52857274 2 - 0.000 0.244 11.605
ENSG00000073712 E005 103.4482863 0.0188063369 9.322550e-11 1.653679e-09 14 52857275 52857530 256 - 1.754 2.283 1.775
ENSG00000073712 E006 358.1702290 0.0039376762 5.399816e-15 1.848200e-13 14 52857531 52858376 846 - 2.374 2.671 0.988
ENSG00000073712 E007 166.0288199 0.0021311587 7.710640e-01 8.522159e-01 14 52858377 52858550 174 - 2.102 2.152 0.170
ENSG00000073712 E008 1.5899021 0.0924482180 7.832998e-01 8.609176e-01 14 52858551 52859305 755 - 0.328 0.401 0.428
ENSG00000073712 E009 0.8148214 0.0196519144 8.591265e-01 9.130997e-01 14 52859306 52859487 182 - 0.194 0.244 0.419
ENSG00000073712 E010 0.7814233 0.1301105871 8.441063e-01 9.029554e-01 14 52859488 52859572 85 - 0.194 0.244 0.417
ENSG00000073712 E011 188.2778974 0.0005301157 9.636585e-01 9.810742e-01 14 52859573 52859714 142 - 2.159 2.197 0.127
ENSG00000073712 E012 0.9317929 0.0663290049 3.530279e-01 4.972719e-01 14 52859715 52860340 626 - 0.194 0.398 1.411
ENSG00000073712 E013 161.6985401 0.0004313829 2.348085e-01 3.681365e-01 14 52860341 52860465 125 - 2.101 2.097 -0.013
ENSG00000073712 E014 5.1247124 0.0332986035 7.066032e-02 1.444366e-01 14 52860466 52861013 548 - 0.741 0.399 -1.584
ENSG00000073712 E015 7.4382998 0.0022376226 3.582972e-01 5.026833e-01 14 52861014 52861034 21 - 0.848 0.741 -0.424
ENSG00000073712 E016 4.0150141 0.0041230007 3.181859e-02 7.550211e-02 14 52861035 52861586 552 - 0.668 0.244 -2.283
ENSG00000073712 E017 1.0695787 0.0115905101 8.607189e-01 9.141519e-01 14 52861587 52861610 24 - 0.266 0.244 -0.167
ENSG00000073712 E018 4.1225197 0.0040648748 7.603933e-01 8.445268e-01 14 52861611 52862184 574 - 0.627 0.603 -0.106
ENSG00000073712 E019 8.0428274 0.0020962796 2.369643e-03 8.366820e-03 14 52862591 52863677 1087 - 0.920 0.399 -2.283
ENSG00000073712 E020 165.3908562 0.0028649888 7.534285e-01 8.393744e-01 14 52864401 52864622 222 - 2.099 2.151 0.173
ENSG00000073712 E021 111.8967080 0.0109940141 6.042435e-01 7.248374e-01 14 52864747 52864853 107 - 1.941 1.943 0.009
ENSG00000073712 E022 137.0405647 0.0026306779 3.426001e-03 1.151338e-02 14 52872799 52872923 125 - 2.047 1.946 -0.338
ENSG00000073712 E023 0.0000000       14 52873662 52873710 49 -      
ENSG00000073712 E024 96.5677851 0.0003308808 9.053068e-04 3.632636e-03 14 52874177 52874226 50 - 1.901 1.776 -0.421
ENSG00000073712 E025 134.2140796 0.0003067105 1.463650e-04 7.314272e-04 14 52875223 52875357 135 - 2.042 1.923 -0.401
ENSG00000073712 E026 104.7573326 0.0003052455 4.426307e-02 9.886936e-02 14 52878582 52878689 108 - 1.926 1.873 -0.178
ENSG00000073712 E027 98.8454793 0.0003728684 6.136279e-02 1.289288e-01 14 52881036 52881108 73 - 1.900 1.851 -0.165
ENSG00000073712 E028 70.4063009 0.0015724816 4.426769e-02 9.887850e-02 14 52881109 52881138 30 - 1.758 1.678 -0.271
ENSG00000073712 E029 162.3373259 0.0010220852 5.555648e-02 1.189320e-01 14 52881244 52881469 226 - 2.110 2.076 -0.116
ENSG00000073712 E030 1.7809454 0.0097299590 3.881925e-01 5.322991e-01 14 52881796 52881828 33 - 0.406 0.243 -1.043
ENSG00000073712 E031 0.1482932 0.0414683802 8.203449e-02   14 52893288 52893292 5 - 0.000 0.243 11.627
ENSG00000073712 E032 82.3990734 0.0030619389 1.818054e-01 3.035008e-01 14 52893293 52893358 66 - 1.820 1.781 -0.129
ENSG00000073712 E033 49.0826644 0.0042111655 5.232434e-02 1.132969e-01 14 52893359 52893375 17 - 1.611 1.503 -0.369
ENSG00000073712 E034 65.5982138 0.0005742450 3.604275e-01 5.047344e-01 14 52893376 52893427 52 - 1.718 1.705 -0.046
ENSG00000073712 E035 114.1566665 0.0086458504 6.166353e-02 1.294260e-01 14 52919123 52919356 234 - 1.966 1.887 -0.265
ENSG00000073712 E036 0.0000000       14 52928020 52928345 326 -      
ENSG00000073712 E037 0.0000000       14 52928346 52928420 75 -      
ENSG00000073712 E038 0.0000000       14 52948562 52948580 19 -      
ENSG00000073712 E039 111.2372206 0.0380316006 6.117503e-03 1.891564e-02 14 52950412 52950577 166 - 1.977 1.730 -0.831
ENSG00000073712 E040 4.7885109 0.0102886274 7.558895e-02 1.524517e-01 14 52950828 52950920 93 - 0.718 0.399 -1.491
ENSG00000073712 E041 58.8335735 0.0030240680 5.494044e-10 8.551020e-09 14 52950921 52951050 130 - 1.725 1.263 -1.589
ENSG00000073712 E042 0.0000000       14 52952318 52952435 118 -