ENSG00000073711

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264977 ENSG00000073711 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R3A protein_coding protein_coding 1.644103 0.8329776 2.752558 0.1129311 0.06338489 1.712439 1.38273931 0.33468923 2.63080546 0.07098922 0.07043750 2.937610 0.7230583 0.39453333 0.9565667 0.56203333 4.348462e-05 4.348462e-05 FALSE TRUE
ENST00000469270 ENSG00000073711 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R3A protein_coding processed_transcript 1.644103 0.8329776 2.752558 0.1129311 0.06338489 1.712439 0.02335814 0.04787182 0.00000000 0.02408683 0.00000000 -2.532861 0.0215500 0.05063333 0.0000000 -0.05063333 3.480728e-02 4.348462e-05 FALSE TRUE
ENST00000490467 ENSG00000073711 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R3A protein_coding protein_coding 1.644103 0.8329776 2.752558 0.1129311 0.06338489 1.712439 0.19360381 0.45041650 0.08249135 0.04417647 0.08249135 -2.315549 0.2160333 0.55486667 0.0295000 -0.52536667 2.016362e-03 4.348462e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000073711 E001 1.2502258 0.0107830691 5.836130e-01 7.076902e-01 3 135965728 135965743 16 + 0.330 0.218 -0.803
ENSG00000073711 E002 4.6587403 0.0034281533 5.596659e-03 1.754543e-02 3 135965744 135965849 106 + 0.769 0.218 -2.904
ENSG00000073711 E003 90.7855518 0.0006351114 1.336600e-08 1.609348e-07 3 136001059 136003493 2435 + 1.936 1.675 -0.883
ENSG00000073711 E004 0.2966881 0.0271562833 1.000000e+00   3 136022735 136023201 467 + 0.122 0.000 -10.135
ENSG00000073711 E005 15.4413798 0.0011769072 1.967246e-01 3.221515e-01 3 136026832 136026956 125 + 1.171 1.032 -0.499
ENSG00000073711 E006 17.7775287 0.0011219774 3.427928e-01 4.868292e-01 3 136026957 136027098 142 + 1.220 1.127 -0.333
ENSG00000073711 E007 15.3440774 0.0012553528 6.193978e-01 7.368340e-01 3 136040859 136040962 104 + 1.156 1.105 -0.185
ENSG00000073711 E008 17.3644796 0.0161602929 3.151688e-01 4.579240e-01 3 136049259 136049361 103 + 1.221 1.104 -0.417
ENSG00000073711 E009 16.5024897 0.0050004623 2.756860e-01 4.150341e-01 3 136070478 136070552 75 + 1.199 1.082 -0.418
ENSG00000073711 E010 15.5782342 0.0222989203 7.958259e-01 8.696247e-01 3 136078367 136078453 87 + 1.157 1.127 -0.107
ENSG00000073711 E011 0.1451727 0.0430063385 1.000000e+00   3 136079150 136079283 134 + 0.065 0.000 -9.110
ENSG00000073711 E012 17.8153034 0.0010966324 2.250738e-01 3.565150e-01 3 136082265 136082421 157 + 1.175 1.284 0.384
ENSG00000073711 E013 11.5984033 0.0015281522 3.566466e-01 5.010288e-01 3 136087883 136087931 49 + 1.004 1.105 0.366
ENSG00000073711 E014 16.5387632 0.0011051374 2.455560e-01 3.807079e-01 3 136090578 136090667 90 + 1.146 1.254 0.382
ENSG00000073711 E015 14.3481721 0.0017417618 3.229821e-01 4.663364e-01 3 136102007 136102102 96 + 1.087 1.186 0.355
ENSG00000073711 E016 12.0077343 0.0043499229 5.009982e-01 6.371983e-01 3 136102103 136102182 80 + 1.057 0.977 -0.294
ENSG00000073711 E017 13.8502181 0.0013329258 2.801985e-01 4.200251e-01 3 136103258 136103376 119 + 1.126 1.005 -0.437
ENSG00000073711 E018 11.6768314 0.0015231401 3.781131e-01 5.224028e-01 3 136106216 136106322 107 + 1.051 0.946 -0.389
ENSG00000073711 E019 0.4031496 0.0237960174 1.999610e-02 5.147991e-02 3 136106480 136106920 441 + 0.000 0.363 12.000
ENSG00000073711 E020 114.3706053 0.0004345701 7.443220e-12 1.581889e-10 3 136145043 136147894 2852 + 1.925 2.140 0.719