ENSG00000073670

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000200557 ENSG00000073670 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM11 protein_coding protein_coding 9.67068 12.82819 7.609621 0.9806712 0.2334428 -0.752651 1.3319831 1.5345874 0.8510378 0.3855389 0.2409943 -0.8430730 0.1434750 0.11626667 0.11126667 -0.00500000 0.9717285 0.0367214 FALSE TRUE
ENST00000355638 ENSG00000073670 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM11 protein_coding nonsense_mediated_decay 9.67068 12.82819 7.609621 0.9806712 0.2334428 -0.752651 2.1944433 3.2550376 1.8200415 0.2111262 0.2283861 -0.8352233 0.2324458 0.25876667 0.24136667 -0.01740000 0.9184324 0.0367214 FALSE TRUE
ENST00000587773 ENSG00000073670 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM11 protein_coding nonsense_mediated_decay 9.67068 12.82819 7.609621 0.9806712 0.2334428 -0.752651 2.6836265 4.5140541 1.8487267 0.3550300 0.2354626 -1.2833016 0.2552667 0.35203333 0.24153333 -0.11050000 0.0367214 0.0367214 TRUE TRUE
ENST00000588363 ENSG00000073670 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM11 protein_coding retained_intron 9.67068 12.82819 7.609621 0.9806712 0.2334428 -0.752651 0.7682635 0.2537519 0.6562551 0.2537519 0.1820349 1.3368931 0.0839375 0.01786667 0.08496667 0.06710000 0.1424575 0.0367214 FALSE FALSE
MSTRG.14457.3 ENSG00000073670 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM11 protein_coding   9.67068 12.82819 7.609621 0.9806712 0.2334428 -0.752651 2.6923638 3.2707616 2.4335599 0.2903615 0.1620289 -0.4250463 0.2848792 0.25510000 0.32086667 0.06576667 0.3541289 0.0367214 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000073670 E001 4.1234686 0.0043713222 4.774365e-01 6.159817e-01 17 44758988 44759178 191 + 0.727 0.646 -0.336
ENSG00000073670 E002 4.2686282 0.0038815425 3.364510e-01 4.802999e-01 17 44759179 44759190 12 + 0.760 0.646 -0.473
ENSG00000073670 E003 11.0741776 0.0016172991 1.488390e-02 4.022986e-02 17 44759191 44759260 70 + 1.184 0.970 -0.779
ENSG00000073670 E004 0.3289534 0.0283775725 6.416918e-01   17 44759325 44759487 163 + 0.156 0.095 -0.822
ENSG00000073670 E005 35.3981197 0.0006131448 1.956794e-01 3.208128e-01 17 44759722 44759897 176 + 1.562 1.513 -0.169
ENSG00000073670 E006 31.9553744 0.0006230192 2.016122e-01 3.281878e-01 17 44769718 44769794 77 + 1.402 1.516 0.393
ENSG00000073670 E007 18.7111103 0.0009544111 8.421515e-01 9.015975e-01 17 44769982 44769985 4 + 1.231 1.276 0.158
ENSG00000073670 E008 27.1679626 0.0007337464 6.663108e-01 7.737846e-01 17 44769986 44770048 63 + 1.371 1.431 0.206
ENSG00000073670 E009 38.6533017 0.0031985079 7.432603e-01 8.319457e-01 17 44771584 44771669 86 + 1.552 1.561 0.033
ENSG00000073670 E010 34.5849362 0.0011326075 8.499035e-02 1.673892e-01 17 44771756 44771831 76 + 1.567 1.490 -0.265
ENSG00000073670 E011 40.4638891 0.0005847680 2.373536e-02 5.926864e-02 17 44772267 44772333 67 + 1.646 1.548 -0.336
ENSG00000073670 E012 43.6194411 0.0004875641 6.981476e-03 2.117547e-02 17 44772399 44772462 64 + 1.691 1.574 -0.397
ENSG00000073670 E013 25.6623990 0.0007578759 2.109264e-01 3.396317e-01 17 44772463 44772466 4 + 1.431 1.371 -0.205
ENSG00000073670 E014 48.3617736 0.0005006289 5.340323e-04 2.287173e-03 17 44772857 44772931 75 + 1.755 1.607 -0.502
ENSG00000073670 E015 47.3474528 0.0005402272 3.186178e-03 1.081548e-02 17 44773014 44773085 72 + 1.731 1.607 -0.422
ENSG00000073670 E016 72.8553830 0.0004323261 8.200462e-04 3.331017e-03 17 44773261 44773427 167 + 1.909 1.797 -0.376
ENSG00000073670 E017 50.7069908 0.0004930565 2.700625e-06 2.042498e-05 17 44774295 44774379 85 + 1.807 1.604 -0.690
ENSG00000073670 E018 50.2486319 0.0004623207 6.942939e-03 2.107512e-02 17 44774492 44774582 91 + 1.745 1.637 -0.364
ENSG00000073670 E019 36.7716824 0.0006397771 5.090273e-02 1.107733e-01 17 44774698 44774749 52 + 1.597 1.510 -0.297
ENSG00000073670 E020 54.6676463 0.0005192448 1.166192e-01 2.151317e-01 17 44775212 44775311 100 + 1.745 1.696 -0.163
ENSG00000073670 E021 48.2977484 0.0004742691 9.226311e-01 9.551975e-01 17 44775394 44775465 72 + 1.633 1.668 0.118
ENSG00000073670 E022 3.4259097 0.0047827701 1.628952e-01 2.789152e-01 17 44775558 44775583 26 + 0.727 0.538 -0.821
ENSG00000073670 E023 45.0166535 0.0051810215 4.039887e-01 5.477343e-01 17 44775584 44775676 93 + 1.642 1.619 -0.077
ENSG00000073670 E024 46.7566912 0.0011995626 1.282353e-01 2.316875e-01 17 44776127 44776207 81 + 1.683 1.630 -0.181
ENSG00000073670 E025 45.0901060 0.0006121188 4.359241e-01 5.780743e-01 17 44776745 44776795 51 + 1.633 1.620 -0.046
ENSG00000073670 E026 45.3470867 0.0029435030 4.790268e-01 6.174322e-01 17 44776899 44776962 64 + 1.633 1.622 -0.039
ENSG00000073670 E027 56.1938733 0.0039706863 7.818295e-01 8.598804e-01 17 44777166 44777265 100 + 1.687 1.734 0.161
ENSG00000073670 E028 0.0000000       17 44777472 44777481 10 +      
ENSG00000073670 E029 68.6900200 0.0070783624 8.585358e-01 9.127342e-01 17 44777482 44777601 120 + 1.778 1.820 0.144
ENSG00000073670 E030 83.4148549 0.0012161817 7.663956e-01 8.489201e-01 17 44777695 44777863 169 + 1.875 1.893 0.060
ENSG00000073670 E031 66.7630905 0.0008976099 7.018602e-01 8.008383e-01 17 44777952 44778066 115 + 1.768 1.815 0.161
ENSG00000073670 E032 60.1193691 0.0199276398 7.583376e-01 8.429745e-01 17 44778152 44778242 91 + 1.719 1.774 0.185
ENSG00000073670 E033 36.8977253 0.0325561525 9.580809e-01 9.777287e-01 17 44779222 44779239 18 + 1.535 1.559 0.082
ENSG00000073670 E034 129.7037830 0.0002668361 2.409652e-01 3.753027e-01 17 44779240 44779669 430 + 2.035 2.103 0.230
ENSG00000073670 E035 599.1112521 0.0027803342 1.336444e-10 2.311772e-09 17 44779739 44781846 2108 + 2.613 2.797 0.615