ENSG00000073417

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394553 ENSG00000073417 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE8A protein_coding protein_coding 6.594154 4.224278 8.813452 0.4961643 0.4050569 1.059227 1.4137809 0.6390913 3.6864145 0.02923602 0.32151175 2.5096333 0.1936083 0.15643333 0.42286667 0.26643333 0.001080912 0.001080912 FALSE TRUE
ENST00000557957 ENSG00000073417 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE8A protein_coding protein_coding 6.594154 4.224278 8.813452 0.4961643 0.4050569 1.059227 2.6691991 2.5119511 3.7140752 0.27277979 0.50280474 0.5623419 0.4073125 0.59756667 0.41846667 -0.17910000 0.064712377 0.001080912 FALSE TRUE
ENST00000558543 ENSG00000073417 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE8A protein_coding retained_intron 6.594154 4.224278 8.813452 0.4961643 0.4050569 1.059227 0.6116160 0.2823331 0.3791353 0.09712359 0.23964550 0.4126589 0.0924750 0.06346667 0.04080000 -0.02266667 0.709727817 0.001080912   FALSE
ENST00000561024 ENSG00000073417 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE8A protein_coding retained_intron 6.594154 4.224278 8.813452 0.4961643 0.4050569 1.059227 0.5848542 0.3619279 0.2380047 0.15532557 0.05292532 -0.5846554 0.0970125 0.07980000 0.02763333 -0.05216667 0.211922734 0.001080912 FALSE TRUE
MSTRG.11455.2 ENSG00000073417 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE8A protein_coding   6.594154 4.224278 8.813452 0.4961643 0.4050569 1.059227 0.6528240 0.1961934 0.1201017 0.19619337 0.12010173 -0.6643578 0.1132167 0.05533333 0.01403333 -0.04130000 0.932214811 0.001080912 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000073417 E001 0.0000000       15 84980440 84980502 63 +      
ENSG00000073417 E002 0.4772466 0.0207084996 2.132014e-01 3.423175e-01 15 84980507 84980512 6 + 0.086 0.292 2.124
ENSG00000073417 E003 4.7290444 0.1570597903 4.845137e-01 6.224927e-01 15 84980513 84980685 173 + 0.797 0.638 -0.656
ENSG00000073417 E004 1.0255583 0.0514483640 3.218096e-01 4.650688e-01 15 84980686 84980690 5 + 0.366 0.170 -1.463
ENSG00000073417 E005 6.9350274 0.0046308615 6.121058e-03 1.892540e-02 15 84981856 84981973 118 + 0.982 0.589 -1.575
ENSG00000073417 E006 3.7543180 0.0243133749 3.381469e-02 7.938550e-02 15 84981974 84981980 7 + 0.767 0.387 -1.754
ENSG00000073417 E007 13.7162528 0.0066114227 1.068021e-06 8.809361e-06 15 84981981 84982225 245 + 1.285 0.685 -2.251
ENSG00000073417 E008 16.1312241 0.0013887567 2.487110e-03 8.725633e-03 15 84982226 84982348 123 + 1.300 1.006 -1.053
ENSG00000073417 E009 0.4439371 0.0215685331 2.906541e-01 4.314594e-01 15 85062497 85064369 1873 + 0.220 0.000 -11.786
ENSG00000073417 E010 12.7059983 0.0020917297 1.112324e-01 2.073671e-01 15 85064370 85064373 4 + 1.173 1.006 -0.604
ENSG00000073417 E011 21.4537518 0.0013961185 6.889983e-02 1.415497e-01 15 85064374 85064426 53 + 1.379 1.227 -0.530
ENSG00000073417 E012 15.1481693 0.0015645236 2.710461e-01 4.097453e-01 15 85067014 85067027 14 + 1.221 1.115 -0.380
ENSG00000073417 E013 43.0200677 0.0043547578 4.893268e-02 1.072586e-01 15 85067028 85067204 177 + 1.666 1.534 -0.449
ENSG00000073417 E014 28.4219567 0.0123612999 3.065952e-01 4.487707e-01 15 85075862 85075918 57 + 1.484 1.389 -0.327
ENSG00000073417 E015 28.3537577 0.0007810631 4.202194e-03 1.370896e-02 15 85076733 85076787 55 + 1.515 1.306 -0.723
ENSG00000073417 E016 39.5144190 0.0006017483 1.050439e-01 1.981525e-01 15 85083556 85083644 89 + 1.621 1.521 -0.340
ENSG00000073417 E017 29.2232775 0.0007270961 5.116694e-02 1.112422e-01 15 85089338 85089416 79 + 1.503 1.364 -0.480
ENSG00000073417 E018 0.6611159 0.0249602421 7.967139e-01 8.702594e-01 15 85090718 85090915 198 + 0.220 0.171 -0.457
ENSG00000073417 E019 41.1879663 0.0017412417 8.951369e-04 3.596856e-03 15 85091044 85091181 138 + 1.666 1.454 -0.726
ENSG00000073417 E020 2.0178152 0.0292431533 1.967663e-01 3.222053e-01 15 85097803 85097947 145 + 0.366 0.590 1.131
ENSG00000073417 E021 39.1150536 0.0005843308 9.011063e-03 2.630708e-02 15 85097948 85098036 89 + 1.637 1.475 -0.553
ENSG00000073417 E022 0.2998086 0.0290491927 5.661281e-01   15 85099757 85099978 222 + 0.086 0.170 1.122
ENSG00000073417 E023 0.2987644 0.0272540135 5.150966e-01   15 85099979 85100014 36 + 0.159 0.000 -11.175
ENSG00000073417 E024 28.6023265 0.0153596866 9.260121e-02 1.791860e-01 15 85100015 85100066 52 + 1.507 1.351 -0.536
ENSG00000073417 E025 26.4010311 0.0219685028 6.297831e-02 1.316733e-01 15 85100156 85100198 43 + 1.482 1.291 -0.662
ENSG00000073417 E026 0.0000000       15 85100199 85100258 60 +      
ENSG00000073417 E027 37.6395931 0.0013274188 4.262698e-02 9.586023e-02 15 85109053 85109130 78 + 1.612 1.482 -0.444
ENSG00000073417 E028 40.5445746 0.0005034725 9.466822e-02 1.823883e-01 15 85113377 85113447 71 + 1.634 1.534 -0.344
ENSG00000073417 E029 57.3882682 0.0004596714 3.909986e-01 5.349415e-01 15 85113873 85114037 165 + 1.761 1.716 -0.152
ENSG00000073417 E030 0.0000000       15 85114038 85114038 1 +      
ENSG00000073417 E031 0.2987644 0.0272540135 5.150966e-01   15 85115256 85115438 183 + 0.159 0.000 -11.175
ENSG00000073417 E032 29.1211468 0.0008468023 6.257322e-01 7.418077e-01 15 85115439 85115487 49 + 1.445 1.475 0.102
ENSG00000073417 E033 0.1451727 0.0429782064 1.000000e+00   15 85115769 85115983 215 + 0.086 0.000 -10.070
ENSG00000073417 E034 57.0337941 0.0004979878 1.830102e-01 3.049612e-01 15 85115984 85116119 136 + 1.722 1.782 0.203
ENSG00000073417 E035 0.2924217 0.0290785164 5.162708e-01   15 85116120 85116309 190 + 0.159 0.000 -11.158
ENSG00000073417 E036 62.1594717 0.0048957300 7.918975e-01 8.668920e-01 15 85117641 85117839 199 + 1.791 1.771 -0.066
ENSG00000073417 E037 3.6674192 0.0044822504 5.904702e-01 7.133289e-01 15 85120191 85120796 606 + 0.676 0.589 -0.377
ENSG00000073417 E038 60.5289880 0.0003964238 2.952201e-01 4.363454e-01 15 85120797 85121014 218 + 1.788 1.735 -0.178
ENSG00000073417 E039 53.8002057 0.0004748507 7.881702e-01 8.643354e-01 15 85123061 85123193 133 + 1.724 1.708 -0.057
ENSG00000073417 E040 55.2048532 0.0004365843 9.483375e-02 1.826348e-01 15 85126207 85126374 168 + 1.702 1.779 0.260
ENSG00000073417 E041 44.7384849 0.0005567832 8.003148e-06 5.435089e-05 15 85136534 85136663 130 + 1.540 1.772 0.787
ENSG00000073417 E042 219.0455192 0.0002797879 5.625815e-33 1.175076e-30 15 85137797 85139145 1349 + 2.209 2.474 0.885