ENSG00000073169

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380903 ENSG00000073169 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOO protein_coding protein_coding 30.51804 53.55417 15.22521 2.673483 1.053664 -1.813859 6.7325819 8.0008813 5.7197574 1.73299128 0.50514052 -0.4834869 0.23777500 0.148433333 0.37476667 0.22633333 0.0004232496 0.0004232496 FALSE TRUE
ENST00000492092 ENSG00000073169 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOO protein_coding processed_transcript 30.51804 53.55417 15.22521 2.673483 1.053664 -1.813859 11.5694708 23.7646816 3.2925030 1.25627953 1.17937555 -2.8477942 0.33102917 0.443966667 0.20930000 -0.23466667 0.0933040577 0.0004232496 FALSE TRUE
MSTRG.22366.10 ENSG00000073169 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOO protein_coding   30.51804 53.55417 15.22521 2.673483 1.053664 -1.813859 2.5742040 7.7211332 0.1572276 2.76772677 0.07944577 -5.5307950 0.07055833 0.144400000 0.01026667 -0.13413333 0.0281655667 0.0004232496 FALSE TRUE
MSTRG.22366.11 ENSG00000073169 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOO protein_coding   30.51804 53.55417 15.22521 2.673483 1.053664 -1.813859 0.8138777 3.3146653 0.0000000 2.08330398 0.00000000 -8.3770653 0.02368333 0.064166667 0.00000000 -0.06416667 0.2847404560 0.0004232496 FALSE TRUE
MSTRG.22366.13 ENSG00000073169 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOO protein_coding   30.51804 53.55417 15.22521 2.673483 1.053664 -1.813859 1.9001667 2.1991290 1.2003751 0.08263535 0.26114033 -0.8680234 0.07438750 0.041166667 0.08096667 0.03980000 0.1651440348 0.0004232496 FALSE TRUE
MSTRG.22366.14 ENSG00000073169 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOO protein_coding   30.51804 53.55417 15.22521 2.673483 1.053664 -1.813859 3.3240819 4.6830177 2.3840748 0.76558768 0.54326630 -0.9710477 0.12266250 0.086466667 0.15390000 0.06743333 0.1535406445 0.0004232496 FALSE TRUE
MSTRG.22366.15 ENSG00000073169 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOO protein_coding   30.51804 53.55417 15.22521 2.673483 1.053664 -1.813859 0.7440619 0.2057271 0.9998569 0.20572715 0.99985695 2.2268713 0.03980000 0.003933333 0.07143333 0.06750000 0.9067354620 0.0004232496 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000073169 E001 6.273596 0.0584919385 4.186319e-02 9.447007e-02 22 50201011 50201029 19 + 1.035 0.686 -1.353
ENSG00000073169 E002 35.593289 0.0675476105 1.843777e-06 1.445530e-05 22 50201030 50201229 200 + 1.889 1.233 -2.246
ENSG00000073169 E003 19.224063 0.0987374763 3.321603e-09 4.470183e-08 22 50201230 50201296 67 + 1.757 0.753 -3.591
ENSG00000073169 E004 11.490747 0.0016026256 4.800024e-27 6.219905e-25 22 50201297 50201318 22 + 1.574 0.479 -4.181
ENSG00000073169 E005 10.763847 0.0543445978 3.582705e-09 4.791957e-08 22 50201319 50201368 50 + 1.485 0.602 -3.301
ENSG00000073169 E006 24.098511 0.0444013434 3.395543e-06 2.511911e-05 22 50201369 50201462 94 + 1.686 1.106 -2.017
ENSG00000073169 E007 73.741252 0.0104686902 2.759019e-03 9.549210e-03 22 50201463 50201590 128 + 1.938 1.727 -0.713
ENSG00000073169 E008 6.422756 0.0026375025 3.705973e-15 1.299677e-13 22 50201719 50201768 50 + 1.328 0.358 -3.986
ENSG00000073169 E009 14.174594 0.0166997554 1.040836e-11 2.160675e-10 22 50201769 50201855 87 + 1.546 0.813 -2.634
ENSG00000073169 E010 9.809238 0.0231470590 8.944833e-07 7.504414e-06 22 50201910 50201931 22 + 1.351 0.732 -2.290
ENSG00000073169 E011 9.731817 0.0165272448 1.261014e-05 8.187232e-05 22 50201932 50201943 12 + 1.304 0.773 -1.955
ENSG00000073169 E012 15.952729 0.0079799426 4.159730e-11 7.821820e-10 22 50201944 50202012 69 + 1.546 0.920 -2.224
ENSG00000073169 E013 60.093360 0.0062412065 5.574783e-11 1.026561e-09 22 50204084 50204341 258 + 1.974 1.569 -1.372
ENSG00000073169 E014 17.811481 0.0013151931 4.358621e-08 4.757866e-07 22 50204706 50204720 15 + 1.501 1.029 -1.662
ENSG00000073169 E015 58.121840 0.0154569493 2.904337e-09 3.953283e-08 22 50204721 50204918 198 + 1.993 1.533 -1.557
ENSG00000073169 E016 28.856505 0.0262660910 1.159921e-06 9.502016e-06 22 50204919 50204922 4 + 1.721 1.218 -1.733
ENSG00000073169 E017 56.692165 0.0071285234 9.450236e-11 1.674447e-09 22 50204923 50205024 102 + 1.961 1.542 -1.418
ENSG00000073169 E018 64.775440 0.0024905564 4.927947e-03 1.572936e-02 22 50206317 50206320 4 + 1.855 1.688 -0.566
ENSG00000073169 E019 160.382075 0.0027047123 5.488776e-02 1.178035e-01 22 50206321 50206441 121 + 2.187 2.094 -0.314
ENSG00000073169 E020 96.211913 0.0009818363 8.362186e-01 8.975891e-01 22 50206442 50206462 21 + 1.902 1.892 -0.032
ENSG00000073169 E021 115.289303 0.0003333624 5.313096e-01 6.637841e-01 22 50206463 50206520 58 + 2.005 1.963 -0.143
ENSG00000073169 E022 34.241388 0.0005874108 8.585532e-08 8.825782e-07 22 50208488 50208535 48 + 1.706 1.354 -1.207
ENSG00000073169 E023 265.057986 0.0001655884 7.900906e-03 2.352872e-02 22 50208536 50208716 181 + 2.289 2.340 0.170
ENSG00000073169 E024 335.620270 0.0001508930 3.824198e-03 1.264853e-02 22 50210181 50210311 131 + 2.394 2.442 0.161
ENSG00000073169 E025 547.743311 0.0001586454 2.284142e-08 2.634223e-07 22 50210631 50210911 281 + 2.577 2.660 0.278
ENSG00000073169 E026 392.833172 0.0002177989 1.203138e-10 2.095338e-09 22 50215717 50215867 151 + 2.396 2.522 0.421
ENSG00000073169 E027 417.345914 0.0007856139 2.792619e-12 6.374137e-11 22 50216691 50216876 186 + 2.399 2.555 0.520
ENSG00000073169 E028 7.122490 0.0992596017 7.570899e-01 8.420372e-01 22 50216953 50216971 19 + 0.869 0.803 -0.257
ENSG00000073169 E029 303.260040 0.0018534088 4.731420e-05 2.681605e-04 22 50216972 50217061 90 + 2.300 2.413 0.376
ENSG00000073169 E030 258.815341 0.0022459934 3.200850e-04 1.461184e-03 22 50217062 50217128 67 + 2.235 2.344 0.363
ENSG00000073169 E031 474.860982 0.0033718358 9.439904e-07 7.873042e-06 22 50217205 50217633 429 + 2.468 2.612 0.479