ENSG00000073150

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395842 ENSG00000073150 HEK293_OSMI2_2hA HEK293_TMG_2hB PANX2 protein_coding protein_coding 3.192486 5.563936 1.972129 0.3336346 0.06265986 -1.491645 2.5161439 4.4267567 1.8150772 0.4219633 0.04013669 -1.281548 0.77976667 0.7922667 0.92133333 0.12906667 0.04325034 0.04325034 FALSE TRUE
ENST00000402472 ENSG00000073150 HEK293_OSMI2_2hA HEK293_TMG_2hB PANX2 protein_coding nonsense_mediated_decay 3.192486 5.563936 1.972129 0.3336346 0.06265986 -1.491645 0.4504579 0.7911218 0.1570518 0.1019264 0.04278469 -2.261726 0.14308333 0.1410000 0.07866667 -0.06233333 0.25544452 0.04325034 FALSE TRUE
MSTRG.22358.1 ENSG00000073150 HEK293_OSMI2_2hA HEK293_TMG_2hB PANX2 protein_coding   3.192486 5.563936 1.972129 0.3336346 0.06265986 -1.491645 0.2172023 0.3126150 0.0000000 0.1885724 0.00000000 -5.011742 0.07470833 0.0607000 0.00000000 -0.06070000 0.33704233 0.04325034 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000073150 E001 0.8082883 0.0363580723 0.202532164 0.32937686 22 50170708 50170730 23 + 0.000 0.284 9.859
ENSG00000073150 E002 2.2873567 0.0067619370 0.425778920 0.56868281 22 50170731 50170754 24 + 0.331 0.483 0.838
ENSG00000073150 E003 3.2482787 0.0049910208 0.154359871 0.26758244 22 50170755 50170760 6 + 0.331 0.599 1.379
ENSG00000073150 E004 26.0731353 0.0008716083 0.595824849 0.71786021 22 50170761 50170956 196 + 1.310 1.353 0.149
ENSG00000073150 E005 8.6436387 0.0020252141 0.998280550 1.00000000 22 50175432 50175482 51 + 0.895 0.896 0.004
ENSG00000073150 E006 36.7037362 0.0235761624 0.784519509 0.86175829 22 50176939 50177189 251 + 1.503 1.483 -0.071
ENSG00000073150 E007 115.0547024 0.0041755068 0.008394433 0.02477528 22 50177190 50178402 1213 + 2.053 1.950 -0.345
ENSG00000073150 E008 53.0357655 0.0039273216 0.385335537 0.52953134 22 50178934 50179135 202 + 1.679 1.629 -0.169
ENSG00000073150 E009 38.0202989 0.0050517679 0.852433725 0.90855957 22 50179136 50179217 82 + 1.510 1.501 -0.034
ENSG00000073150 E010 21.9489002 0.0130841856 0.971413053 0.98613372 22 50179218 50179220 3 + 1.272 1.275 0.011
ENSG00000073150 E011 177.5985075 0.0042722631 0.012531115 0.03480894 22 50179221 50180458 1238 + 2.092 2.181 0.296