ENSG00000072958

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000429941 ENSG00000072958 HEK293_OSMI2_2hA HEK293_TMG_2hB AP1M1 protein_coding protein_coding 120.9719 190.843 80.63857 17.08722 1.776793 -1.242741 28.23614 54.75716 16.89372 2.267501 0.6051639 -1.6959704 0.2190958 0.2901333 0.2098 -0.08033333 0.03321628 0.0003582153 FALSE  
ENST00000589991 ENSG00000072958 HEK293_OSMI2_2hA HEK293_TMG_2hB AP1M1 protein_coding retained_intron 120.9719 190.843 80.63857 17.08722 1.776793 -1.242741 27.60023 31.13698 23.46816 9.349344 0.7279245 -0.4077733 0.2406250 0.1568000 0.2909 0.13410000 0.07612004 0.0003582153 FALSE  
ENST00000590756 ENSG00000072958 HEK293_OSMI2_2hA HEK293_TMG_2hB AP1M1 protein_coding protein_coding 120.9719 190.843 80.63857 17.08722 1.776793 -1.242741 55.19436 92.68556 33.66908 5.628064 0.5321780 -1.4606477 0.4491250 0.4886667 0.4177 -0.07096667 0.08031011 0.0003582153 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000072958 E001 14.9280644 0.0524380276 9.550238e-03 2.765951e-02 19 16197854 16197910 57 + 1.355 1.023 -1.181
ENSG00000072958 E002 15.2310952 0.0502074482 5.155589e-03 1.635237e-02 19 16197911 16197912 2 + 1.376 1.023 -1.254
ENSG00000072958 E003 86.1638307 0.0062849611 3.663287e-13 9.617498e-12 19 16197913 16197933 21 + 2.119 1.741 -1.271
ENSG00000072958 E004 275.3778293 0.0088459216 8.518720e-05 4.525747e-04 19 16197934 16197970 37 + 2.489 2.314 -0.586
ENSG00000072958 E005 288.6084074 0.0086541112 4.018486e-04 1.781590e-03 19 16197971 16197973 3 + 2.494 2.340 -0.512
ENSG00000072958 E006 375.2016160 0.0074195215 3.665564e-04 1.644868e-03 19 16197974 16198010 37 + 2.597 2.458 -0.464
ENSG00000072958 E007 442.0784977 0.0053631440 1.970191e-03 7.132830e-03 19 16198011 16198068 58 + 2.640 2.540 -0.333
ENSG00000072958 E008 0.4470576 0.0228627246 1.309262e-01 2.354337e-01 19 16198069 16198077 9 + 0.324 0.076 -2.544
ENSG00000072958 E009 0.1817044 0.0390508752 1.000000e+00   19 16198143 16198156 14 + 0.000 0.076 8.293
ENSG00000072958 E010 0.4031496 0.0243711690 7.173839e-01 8.127765e-01 19 16198157 16198308 152 + 0.000 0.141 9.295
ENSG00000072958 E011 0.5085815 0.2237980297 7.308608e-01 8.226579e-01 19 16202947 16202988 42 + 0.192 0.141 -0.533
ENSG00000072958 E012 1.3180011 0.0206311650 9.259998e-02 1.791854e-01 19 16202989 16203101 113 + 0.000 0.369 11.104
ENSG00000072958 E013 279.0944542 0.0039507375 7.410412e-03 2.228594e-02 19 16203459 16203462 4 + 2.428 2.344 -0.280
ENSG00000072958 E014 762.2108611 0.0028812595 1.837728e-03 6.720046e-03 19 16203463 16203605 143 + 2.853 2.784 -0.231
ENSG00000072958 E015 347.1602990 0.0005784959 3.555552e-01 4.999247e-01 19 16203606 16203615 10 + 2.461 2.455 -0.021
ENSG00000072958 E016 545.4743338 0.0008345798 1.025952e-01 1.944588e-01 19 16206341 16206408 68 + 2.668 2.649 -0.061
ENSG00000072958 E017 1.7694007 0.2233367037 4.210793e-01 5.642194e-01 19 16206409 16206494 86 + 0.507 0.338 -0.914
ENSG00000072958 E018 771.3346524 0.0001346137 8.931786e-02 1.740933e-01 19 16208019 16208149 131 + 2.811 2.801 -0.034
ENSG00000072958 E019 2.0920245 0.0086450451 2.116760e-01 3.404597e-01 19 16208150 16208262 113 + 0.577 0.369 -1.054
ENSG00000072958 E020 3.5386095 0.0093967798 1.189940e-01 2.185019e-01 19 16208850 16208958 109 + 0.324 0.629 1.550
ENSG00000072958 E021 2.7720512 0.0932777532 3.490937e-01 4.933294e-01 19 16208959 16209029 71 + 0.325 0.546 1.180
ENSG00000072958 E022 826.6985876 0.0002043523 1.782112e-02 4.675407e-02 19 16209030 16209177 148 + 2.848 2.828 -0.067
ENSG00000072958 E023 3.1216693 0.0051815694 4.040353e-01 5.477543e-01 19 16209178 16209256 79 + 0.426 0.587 0.780
ENSG00000072958 E024 6.3602839 0.0026007690 2.059043e-01 3.335553e-01 19 16210360 16210395 36 + 0.637 0.839 0.827
ENSG00000072958 E025 802.7853687 0.0001868801 5.808436e-04 2.463047e-03 19 16226421 16226547 127 + 2.848 2.811 -0.122
ENSG00000072958 E026 18.2903993 0.0012235054 2.012973e-05 1.247552e-04 19 16226548 16226746 199 + 1.442 1.102 -1.195
ENSG00000072958 E027 595.4070330 0.0001559506 4.956983e-01 6.324703e-01 19 16227548 16227604 57 + 2.687 2.691 0.013
ENSG00000072958 E028 776.1686322 0.0003825856 1.229667e-01 2.241931e-01 19 16227605 16227690 86 + 2.813 2.804 -0.031
ENSG00000072958 E029 708.5769305 0.0007566340 3.646958e-02 8.447769e-02 19 16228137 16228208 72 + 2.787 2.763 -0.079
ENSG00000072958 E030 1098.1630482 0.0002993328 3.689928e-01 5.134267e-01 19 16228770 16228928 159 + 2.954 2.959 0.013
ENSG00000072958 E031 940.8083422 0.0002707223 8.056883e-04 3.278952e-03 19 16233493 16233618 126 + 2.836 2.905 0.229
ENSG00000072958 E032 14.7097334 0.0033376413 1.100939e-01 2.056717e-01 19 16234044 16234198 155 + 1.219 1.075 -0.513
ENSG00000072958 E033 721.5841571 0.0008251003 2.649297e-07 2.479260e-06 19 16234199 16234274 76 + 2.675 2.801 0.421
ENSG00000072958 E034 2936.8721919 0.0027648958 4.626408e-10 7.285612e-09 19 16234413 16235146 734 + 3.256 3.418 0.537
ENSG00000072958 E035 611.7514393 0.0048903110 6.047312e-07 5.264430e-06 19 16235147 16245906 10760 + 2.534 2.745 0.704