ENSG00000072954

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000187762	ENSG00000072954	HEK293_OSMI2_2hA	HEK293_TMG_2hB	TMEM38A	protein_coding	protein_coding	7.385697	10.87228	5.563174	0.4011933	0.21909	-0.9654095	4.377423	5.053055	4.040482	0.3473367	0.1711016	-0.3219145	0.6067333	0.4682333	0.7264667	0.2582333	8.676701e-04	1.258951e-06	FALSE	TRUE
ENST00000595452	ENSG00000072954	HEK293_OSMI2_2hA	HEK293_TMG_2hB	TMEM38A	protein_coding	retained_intron	7.385697	10.87228	5.563174	0.4011933	0.21909	-0.9654095	2.947970	5.336796	1.522692	0.2717253	0.1155427	-1.8026066	0.3881000	0.4904333	0.2735333	-0.2169000	1.258951e-06	1.258951e-06	FALSE	FALSE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
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width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000072954	E001	17.34734	0.0012208213	6.805586e-01	7.844257e-01	19	16661139	16661241	103	+	1.256	1.212	-0.158
ENSG00000072954	E002	18.14409	0.0012115903	8.107478e-01	8.799450e-01	19	16661242	16661260	19	+	1.267	1.237	-0.106
ENSG00000072954	E003	30.72960	0.0006556798	5.378906e-01	6.693803e-01	19	16661261	16661341	81	+	1.449	1.478	0.102
ENSG00000072954	E004	54.28885	0.0004993049	1.195743e-01	2.193548e-01	19	16679984	16680140	157	+	1.663	1.729	0.225
ENSG00000072954	E005	51.64830	0.0005134818	6.720797e-02	1.387102e-01	19	16680397	16680484	88	+	1.629	1.711	0.280
ENSG00000072954	E006	49.37014	0.0005667172	7.571908e-01	8.420902e-01	19	16680485	16680581	97	+	1.663	1.668	0.018
ENSG00000072954	E007	52.74469	0.0050633718	1.790408e-08	2.106100e-07	19	16680582	16680937	356	+	1.435	1.787	1.200
ENSG00000072954	E008	33.79561	0.0006294494	1.124649e-02	3.175283e-02	19	16682421	16682508	88	+	1.610	1.449	-0.551
ENSG00000072954	E009	41.58880	0.0013628988	2.771480e-02	6.745229e-02	19	16686288	16686405	118	+	1.679	1.547	-0.451
ENSG00000072954	E010	110.65941	0.0096769273	4.570562e-03	1.473937e-02	19	16688144	16688922	779	+	2.113	1.961	-0.512
ENSG00000072954	E011	153.64379	0.0024404272	7.912127e-01	8.664779e-01	19	16688923	16690023	1101	+	2.161	2.159	-0.004

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000072954

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3