ENSG00000072803

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296933 ENSG00000072803 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW11 protein_coding protein_coding 22.95062 15.69371 32.48868 2.498819 0.7912535 1.049275 15.91585 13.9956504 20.412548 2.38694207 0.8481656 0.5441539 0.725925 0.8890667 0.6278333 -0.2612333 7.250141e-16 7.250141e-16 FALSE TRUE
ENST00000393802 ENSG00000072803 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW11 protein_coding protein_coding 22.95062 15.69371 32.48868 2.498819 0.7912535 1.049275 3.32417 0.4962417 5.976242 0.07593158 0.3454745 3.5637523 0.121450 0.0330000 0.1846333 0.1516333 1.447996e-10 7.250141e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000072803 E001 1.1404508 0.0115169618 6.222977e-02 1.303961e-01 5 171861549 171861551 3 - 0.162 0.524 2.376
ENSG00000072803 E002 964.1017237 0.0040417716 1.271741e-28 1.892596e-26 5 171861552 171863104 1553 - 2.802 3.162 1.197
ENSG00000072803 E003 347.8954878 0.0003849987 4.870830e-16 1.916436e-14 5 171863105 171863620 516 - 2.433 2.666 0.777
ENSG00000072803 E004 261.4650816 0.0002686589 5.571674e-01 6.856363e-01 5 171863621 171863926 306 - 2.386 2.443 0.189
ENSG00000072803 E005 220.2036741 0.0002037054 7.588662e-03 2.274214e-02 5 171863927 171864101 175 - 2.333 2.337 0.015
ENSG00000072803 E006 0.3729606 0.0425824776 6.695299e-01 7.763333e-01 5 171867778 171867834 57 - 0.088 0.167 1.059
ENSG00000072803 E007 3.2837572 0.0059215653 3.447810e-02 8.067402e-02 5 171867835 171868044 210 - 0.448 0.821 1.639
ENSG00000072803 E008 4.5306971 0.0036890451 3.091819e-03 1.053614e-02 5 171868045 171868149 105 - 0.513 0.975 1.902
ENSG00000072803 E009 223.1693061 0.0002775146 6.065579e-02 1.277323e-01 5 171868610 171868796 187 - 2.331 2.354 0.078
ENSG00000072803 E010 136.8699096 0.0019525788 9.832690e-01 9.936170e-01 5 171869729 171869807 79 - 2.101 2.165 0.215
ENSG00000072803 E011 186.3403890 0.0022641686 2.971512e-01 4.384620e-01 5 171870748 171870858 111 - 2.250 2.276 0.088
ENSG00000072803 E012 214.8767951 0.0001753045 1.012113e-04 5.274731e-04 5 171872872 171872990 119 - 2.333 2.307 -0.089
ENSG00000072803 E013 215.2605872 0.0002463216 6.187497e-07 5.374365e-06 5 171876285 171876401 117 - 2.344 2.287 -0.191
ENSG00000072803 E014 209.2801688 0.0002511759 2.356411e-07 2.227731e-06 5 171876402 171876534 133 - 2.335 2.272 -0.211
ENSG00000072803 E015 152.5539887 0.0028725731 1.097338e-06 9.029946e-06 5 171878011 171878129 119 - 2.217 2.094 -0.414
ENSG00000072803 E016 130.9622089 0.0002627641 9.709689e-09 1.200386e-07 5 171891467 171891604 138 - 2.148 2.029 -0.399
ENSG00000072803 E017 106.6432211 0.0002564880 1.181984e-05 7.723358e-05 5 171899004 171899094 91 - 2.051 1.964 -0.294
ENSG00000072803 E018 74.2105460 0.0003792419 3.012106e-04 1.384699e-03 5 171899914 171899932 19 - 1.897 1.811 -0.289
ENSG00000072803 E019 190.6657680 0.0001902966 1.784866e-20 1.207203e-18 5 171899933 171900100 168 - 2.330 2.143 -0.627
ENSG00000072803 E020 0.1472490 0.0452500412 9.055981e-01   5 171908709 171908859 151 - 0.088 0.000 -9.026
ENSG00000072803 E021 120.1103259 0.0002811431 2.116247e-14 6.638793e-13 5 171910572 171910630 59 - 2.134 1.934 -0.669
ENSG00000072803 E022 104.3777975 0.0002791522 1.845043e-10 3.109768e-09 5 171910631 171910671 41 - 2.065 1.897 -0.565
ENSG00000072803 E023 109.8640780 0.0003050499 1.077683e-07 1.088235e-06 5 171910672 171910733 62 - 2.072 1.950 -0.410
ENSG00000072803 E024 97.0716808 0.0029325827 1.270214e-05 8.240751e-05 5 171910734 171910797 64 - 2.023 1.886 -0.463
ENSG00000072803 E025 42.8888508 0.0019676460 1.514361e-05 9.656384e-05 5 171914343 171914405 63 - 1.691 1.492 -0.680
ENSG00000072803 E026 1.5887561 0.0090651219 6.875479e-01 7.898723e-01 5 171957597 171957698 102 - 0.412 0.382 -0.167
ENSG00000072803 E027 0.1515154 0.0443226845 9.056628e-01   5 171977636 171977756 121 - 0.088 0.000 -9.027
ENSG00000072803 E028 21.2534898 0.0244303159 2.171028e-02 5.507428e-02 5 171996890 171997051 162 - 1.397 1.202 -0.682
ENSG00000072803 E029 1.8758673 0.0077413391 1.417222e-01 2.503949e-01 5 172003181 172003310 130 - 0.513 0.288 -1.265
ENSG00000072803 E030 79.3740823 0.0196612812 1.516168e-04 7.542501e-04 5 172006458 172006873 416 - 1.968 1.711 -0.868